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Fusion gene ID: 14660

FusionGeneSummary for GIPC1_UBE2D2

Fusion gene summary

Fusion gene information	Fusion gene name: GIPC1_UBE2D2
	Fusion gene ID: 14660
		Hgene	Tgene
	Gene symbol	GIPC1	UBE2D2
	Gene ID	10755	7322
	Gene name	GIPC PDZ domain containing family member 1	ubiquitin conjugating enzyme E2 D2
	Synonyms	C19orf3\|GIPC\|GLUT1CBP\|Hs.6454\|IIP-1\|NIP\|RGS19IP1\|SEMCAP\|SYNECTIIN\|SYNECTIN\|TIP-2	E2(17)KB2\|PUBC1\|UBC4\|UBC4/5\|UBCH4\|UBCH5B
	Cytomap	19p13.12	5q31.2
	Type of gene	protein-coding	protein-coding
	Description	PDZ domain-containing protein GIPC1GAIP C-terminus-interacting proteinGLUT1 C-terminal binding proteinIGF-1 receptor interacting protein 1RGS-GAIP-interacting proteinRGS19-interacting protein 1regulator of G-protein signalling 19 interacting protein	ubiquitin-conjugating enzyme E2 D2(E3-independent) E2 ubiquitin-conjugating enzyme D2E2 ubiquitin-conjugating enzyme D2p53-regulated ubiquitin-conjugating enzyme 1ubiquitin carrier protein D2ubiquitin conjugating enzyme E2D 2ubiquitin-conjugating en
	Modification date	20180522	20180523
	UniProtAcc	O14908	P62837
	Ensembl transtripts involved in fusion gene	ENST00000393029, ENST00000393028, ENST00000345425, ENST00000393033, ENST00000591349, ENST00000586027,	ENST00000511725, ENST00000253815, ENST00000398733, ENST00000505548,
Fusion gene scores	* DoF score	6 X 4 X 4=96	5 X 5 X 4=100
	# samples	6	6
	** MAII score	log2(6/96*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: GIPC1 [Title/Abstract] AND UBE2D2 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	UBE2D2	GO:0000209	protein polyubiquitination	15247280
Tgene	UBE2D2	GO:0016567	protein ubiquitination	9990509\|14593114
Tgene	UBE2D2	GO:0051865	protein autoubiquitination	21068390
Tgene	UBE2D2	GO:0070936	protein K48-linked ubiquitination	20061386

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	LUSC	TCGA-85-7696-01A	GIPC1	chr19	14602468	-	UBE2D2	chr5	138979957	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-5UTR	ENST00000393029	ENST00000511725	GIPC1	chr19	14602468	-	UBE2D2	chr5	138979957	+
5UTR-5UTR	ENST00000393029	ENST00000253815	GIPC1	chr19	14602468	-	UBE2D2	chr5	138979957	+
5UTR-5UTR	ENST00000393029	ENST00000398733	GIPC1	chr19	14602468	-	UBE2D2	chr5	138979957	+
5UTR-5UTR	ENST00000393029	ENST00000505548	GIPC1	chr19	14602468	-	UBE2D2	chr5	138979957	+
intron-5UTR	ENST00000393028	ENST00000511725	GIPC1	chr19	14602468	-	UBE2D2	chr5	138979957	+
intron-5UTR	ENST00000393028	ENST00000253815	GIPC1	chr19	14602468	-	UBE2D2	chr5	138979957	+
intron-5UTR	ENST00000393028	ENST00000398733	GIPC1	chr19	14602468	-	UBE2D2	chr5	138979957	+
intron-5UTR	ENST00000393028	ENST00000505548	GIPC1	chr19	14602468	-	UBE2D2	chr5	138979957	+
intron-5UTR	ENST00000345425	ENST00000511725	GIPC1	chr19	14602468	-	UBE2D2	chr5	138979957	+
intron-5UTR	ENST00000345425	ENST00000253815	GIPC1	chr19	14602468	-	UBE2D2	chr5	138979957	+
intron-5UTR	ENST00000345425	ENST00000398733	GIPC1	chr19	14602468	-	UBE2D2	chr5	138979957	+
intron-5UTR	ENST00000345425	ENST00000505548	GIPC1	chr19	14602468	-	UBE2D2	chr5	138979957	+
5UTR-5UTR	ENST00000393033	ENST00000511725	GIPC1	chr19	14602468	-	UBE2D2	chr5	138979957	+
5UTR-5UTR	ENST00000393033	ENST00000253815	GIPC1	chr19	14602468	-	UBE2D2	chr5	138979957	+
5UTR-5UTR	ENST00000393033	ENST00000398733	GIPC1	chr19	14602468	-	UBE2D2	chr5	138979957	+
5UTR-5UTR	ENST00000393033	ENST00000505548	GIPC1	chr19	14602468	-	UBE2D2	chr5	138979957	+
5UTR-5UTR	ENST00000591349	ENST00000511725	GIPC1	chr19	14602468	-	UBE2D2	chr5	138979957	+
5UTR-5UTR	ENST00000591349	ENST00000253815	GIPC1	chr19	14602468	-	UBE2D2	chr5	138979957	+
5UTR-5UTR	ENST00000591349	ENST00000398733	GIPC1	chr19	14602468	-	UBE2D2	chr5	138979957	+
5UTR-5UTR	ENST00000591349	ENST00000505548	GIPC1	chr19	14602468	-	UBE2D2	chr5	138979957	+
5UTR-5UTR	ENST00000586027	ENST00000511725	GIPC1	chr19	14602468	-	UBE2D2	chr5	138979957	+
5UTR-5UTR	ENST00000586027	ENST00000253815	GIPC1	chr19	14602468	-	UBE2D2	chr5	138979957	+
5UTR-5UTR	ENST00000586027	ENST00000398733	GIPC1	chr19	14602468	-	UBE2D2	chr5	138979957	+
5UTR-5UTR	ENST00000586027	ENST00000505548	GIPC1	chr19	14602468	-	UBE2D2	chr5	138979957	+

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FusionProtFeatures for GIPC1_UBE2D2

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GIPC1 O14908	UBE2D2 P62837

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Fusion gene ID: 14660

FusionGeneSummary for GIPC1_UBE2D2

FusionProtFeatures for GIPC1_UBE2D2