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Fusion gene ID: 14652 |
FusionGeneSummary for GINS2_C16orf74 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GINS2_C16orf74 | Fusion gene ID: 14652 | Hgene | Tgene | Gene symbol | GINS2 | C16orf74 | Gene ID | 51659 | 404550 |
| Gene name | GINS complex subunit 2 | chromosome 16 open reading frame 74 | |
| Synonyms | HSPC037|PSF2|Pfs2 | - | |
| Cytomap | 16q24.1 | 16q24.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | DNA replication complex GINS protein PSF2GINS complex subunit 2 (Psf2 homolog) | uncharacterized protein C16orf74hypothetical protein 1hypothetical protein 2hypothetical protein 3 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9Y248 | Q96GX8 | |
| Ensembl transtripts involved in fusion gene | ENST00000253462, | ENST00000602758, ENST00000602719, ENST00000602583, ENST00000602675, ENST00000284245, ENST00000602914, ENST00000602766, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 3 X 3 X 3=27 |
| # samples | 2 | 3 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: GINS2 [Title/Abstract] AND C16orf74 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-E7-A541-01A | GINS2 | chr16 | 85722415 | - | C16orf74 | chr16 | 85768841 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000253462 | ENST00000602758 | GINS2 | chr16 | 85722415 | - | C16orf74 | chr16 | 85768841 | - |
| 5CDS-5UTR | ENST00000253462 | ENST00000602719 | GINS2 | chr16 | 85722415 | - | C16orf74 | chr16 | 85768841 | - |
| 5CDS-intron | ENST00000253462 | ENST00000602583 | GINS2 | chr16 | 85722415 | - | C16orf74 | chr16 | 85768841 | - |
| 5CDS-5UTR | ENST00000253462 | ENST00000602675 | GINS2 | chr16 | 85722415 | - | C16orf74 | chr16 | 85768841 | - |
| 5CDS-5UTR | ENST00000253462 | ENST00000284245 | GINS2 | chr16 | 85722415 | - | C16orf74 | chr16 | 85768841 | - |
| 5CDS-5UTR | ENST00000253462 | ENST00000602914 | GINS2 | chr16 | 85722415 | - | C16orf74 | chr16 | 85768841 | - |
| 5CDS-5UTR | ENST00000253462 | ENST00000602766 | GINS2 | chr16 | 85722415 | - | C16orf74 | chr16 | 85768841 | - |
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FusionProtFeatures for GINS2_C16orf74 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GINS2 | C16orf74 |