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Fusion gene ID: 14596 |
FusionGeneSummary for GGCX_KCMF1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GGCX_KCMF1 | Fusion gene ID: 14596 | Hgene | Tgene | Gene symbol | GGCX | KCMF1 | Gene ID | 2677 | 56888 |
| Gene name | gamma-glutamyl carboxylase | potassium channel modulatory factor 1 | |
| Synonyms | VKCFD1 | DEBT91|FIGC|PCMF|ZZZ1 | |
| Cytomap | 2p11.2 | 2p11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | vitamin K-dependent gamma-carboxylasepeptidyl-glutamate 4-carboxylase | E3 ubiquitin-protein ligase KCMF1FGF-induced in gastric cancerFGF-induced ubiquitin-protein ligase in gastric cancersRING-type E3 ubiquitin transferase KCMF1ZZ-type zinc finger-containing protein 1differentially expressed in branching tubulogenesis 9 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | P38435 | Q9P0J7 | |
| Ensembl transtripts involved in fusion gene | ENST00000233838, ENST00000430215, ENST00000473665, | ENST00000409785, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 5 X 5 X 3=75 |
| # samples | 3 | 7 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/75*10)=-0.0995356735509144 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: GGCX [Title/Abstract] AND KCMF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PRAD | TCGA-HC-A76X-01A | GGCX | chr2 | 85787938 | - | KCMF1 | chr2 | 85255012 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000233838 | ENST00000409785 | GGCX | chr2 | 85787938 | - | KCMF1 | chr2 | 85255012 | + |
| intron-3CDS | ENST00000430215 | ENST00000409785 | GGCX | chr2 | 85787938 | - | KCMF1 | chr2 | 85255012 | + |
| intron-3CDS | ENST00000473665 | ENST00000409785 | GGCX | chr2 | 85787938 | - | KCMF1 | chr2 | 85255012 | + |
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FusionProtFeatures for GGCX_KCMF1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GGCX | KCMF1 |
| Mediates the vitamin K-dependent carboxylation ofglutamate residues to calcium-binding gamma-carboxyglutamate (Gla)residues with the concomitant conversion of the reducedhydroquinone form of vitamin K to vitamin K epoxide.{ECO:0000269|PubMed:17073445}. | Has intrinsic E3 ubiquitin ligase activity and promotesubiquitination. {ECO:0000269|PubMed:15581609}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | GGCX | chr2:85787938 | chr2:85255012 | ENST00000233838 | - | 2 | 15 | 2_60 | 71 | 759 | Topological domain | Cytoplasmic |
| Tgene | >KCMF1 | chr2:85787938 | chr2:85255012 | ENST00000409785 | + | 0 | 7 | 225_257 | 5 | 382 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >KCMF1 | chr2:85787938 | chr2:85255012 | ENST00000409785 | + | 0 | 7 | 333_336 | 5 | 382 | Compositional bias | Note=Poly-Ser |
| Tgene | >KCMF1 | chr2:85787938 | chr2:85255012 | ENST00000409785 | + | 0 | 7 | 376_380 | 5 | 382 | Compositional bias | Note=Poly-Pro |
| Tgene | >KCMF1 | chr2:85787938 | chr2:85255012 | ENST00000409785 | + | 0 | 7 | 3_50 | 5 | 382 | Zinc finger | ZZ-type |
| Tgene | >KCMF1 | chr2:85787938 | chr2:85255012 | ENST00000409785 | + | 0 | 7 | 78_101 | 5 | 382 | Zinc finger | C2H2-type |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >GGCX | chr2:85787938 | chr2:85255012 | ENST00000233838 | - | 2 | 15 | 135_136 | 71 | 759 | Topological domain | Cytoplasmic |
| Hgene | >GGCX | chr2:85787938 | chr2:85255012 | ENST00000233838 | - | 2 | 15 | 158_292 | 71 | 759 | Topological domain | Lumenal |
| Hgene | >GGCX | chr2:85787938 | chr2:85255012 | ENST00000233838 | - | 2 | 15 | 314_361 | 71 | 759 | Topological domain | Cytoplasmic |
| Hgene | >GGCX | chr2:85787938 | chr2:85255012 | ENST00000233838 | - | 2 | 15 | 383_758 | 71 | 759 | Topological domain | Lumenal |
| Hgene | >GGCX | chr2:85787938 | chr2:85255012 | ENST00000233838 | - | 2 | 15 | 82_113 | 71 | 759 | Topological domain | Lumenal |
| Hgene | >GGCX | chr2:85787938 | chr2:85255012 | ENST00000430215 | - | 1 | 14 | 135_136 | -35 | 702 | Topological domain | Cytoplasmic |
| Hgene | >GGCX | chr2:85787938 | chr2:85255012 | ENST00000430215 | - | 1 | 14 | 158_292 | -35 | 702 | Topological domain | Lumenal |
| Hgene | >GGCX | chr2:85787938 | chr2:85255012 | ENST00000430215 | - | 1 | 14 | 2_60 | -35 | 702 | Topological domain | Cytoplasmic |
| Hgene | >GGCX | chr2:85787938 | chr2:85255012 | ENST00000430215 | - | 1 | 14 | 314_361 | -35 | 702 | Topological domain | Cytoplasmic |
| Hgene | >GGCX | chr2:85787938 | chr2:85255012 | ENST00000430215 | - | 1 | 14 | 383_758 | -35 | 702 | Topological domain | Lumenal |
| Hgene | >GGCX | chr2:85787938 | chr2:85255012 | ENST00000430215 | - | 1 | 14 | 82_113 | -35 | 702 | Topological domain | Lumenal |
| Hgene | >GGCX | chr2:85787938 | chr2:85255012 | ENST00000233838 | - | 2 | 15 | 114_134 | 71 | 759 | Transmembrane | Helical |
| Hgene | >GGCX | chr2:85787938 | chr2:85255012 | ENST00000233838 | - | 2 | 15 | 137_157 | 71 | 759 | Transmembrane | Helical |
| Hgene | >GGCX | chr2:85787938 | chr2:85255012 | ENST00000233838 | - | 2 | 15 | 293_313 | 71 | 759 | Transmembrane | Helical |
| Hgene | >GGCX | chr2:85787938 | chr2:85255012 | ENST00000233838 | - | 2 | 15 | 362_382 | 71 | 759 | Transmembrane | Helical |
| Hgene | >GGCX | chr2:85787938 | chr2:85255012 | ENST00000233838 | - | 2 | 15 | 61_81 | 71 | 759 | Transmembrane | Helical |
| Hgene | >GGCX | chr2:85787938 | chr2:85255012 | ENST00000430215 | - | 1 | 14 | 114_134 | -35 | 702 | Transmembrane | Helical |
| Hgene | >GGCX | chr2:85787938 | chr2:85255012 | ENST00000430215 | - | 1 | 14 | 137_157 | -35 | 702 | Transmembrane | Helical |
| Hgene | >GGCX | chr2:85787938 | chr2:85255012 | ENST00000430215 | - | 1 | 14 | 293_313 | -35 | 702 | Transmembrane | Helical |
| Hgene | >GGCX | chr2:85787938 | chr2:85255012 | ENST00000430215 | - | 1 | 14 | 362_382 | -35 | 702 | Transmembrane | Helical |
| Hgene | >GGCX | chr2:85787938 | chr2:85255012 | ENST00000430215 | - | 1 | 14 | 61_81 | -35 | 702 | Transmembrane | Helical |
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FusionGeneSequence for GGCX_KCMF1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_GGCX_ENST00000233838_chr2_85787938_-_KCMF1_ENST00000409785_chr2_85255012_+_448aa MAVSAGSARTSPSSDKVQKDKAELISGPRQDSRIGKLLGFEWTDLSSWRRLVTLLNRPTDPASLAVFRFLFGVSCDACLKGNFRGRRYKC LICYDYDLCASCYESGATTTRHTTDHPMQCILTRVDFDLYYGGEAFSVEQPQSFTCPYCGKMGYTETSLQEHVTSEHAETSTEVICPICA ALPGGDPNHVTDDFAAHLTLEHRAPRDLDESSGVRHVRRMFHPGRGLGGPRARRSNMHFTSSSTGGLSSSQSSYSPSNREAMDPIAELLS QLSGVRRSAGGQLNSSGPSASQLQQLQMQLQLERQHAQAARQQLETARNATRRTNTSSVTTTITQSTATTNIANTESSQQTLQNSQFLLT |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_GGCX_ENST00000233838_chr2_85787938_-_KCMF1_ENST00000409785_chr2_85255012_+_1344nt ATGGCGGTGTCTGCCGGGTCCGCGCGGACCTCGCCCAGCTCAGATAAAGTACAGAAAGACAAGGCTGAACTGATCTCAGGGCCCAGGCAG GACAGCCGAATAGGGAAACTCTTGGGTTTTGAGTGGACAGATTTGTCCAGTTGGCGGAGGCTGGTGACCCTGCTGAATCGACCAACGGAC CCTGCAAGCTTAGCTGTCTTTCGTTTTCTTTTTGGTGTCAGCTGTGATGCATGTTTAAAAGGAAATTTTCGAGGTCGCAGATATAAGTGT TTAATTTGCTACGATTACGATCTTTGTGCATCTTGTTATGAAAGTGGTGCAACAACAACAAGGCATACAACTGACCACCCAATGCAGTGC ATATTAACAAGGGTAGATTTTGATTTATACTATGGTGGGGAAGCTTTCTCTGTAGAGCAGCCACAGTCTTTTACTTGTCCCTATTGTGGA AAAATGGGCTATACGGAGACATCTCTTCAAGAACATGTTACTTCTGAACATGCAGAAACATCAACAGAAGTGATTTGTCCAATATGTGCA GCGTTACCTGGAGGCGATCCTAATCATGTCACGGATGACTTTGCAGCTCATCTTACACTTGAACACAGAGCCCCTAGAGATTTAGATGAA TCGAGTGGTGTTCGACATGTACGTAGAATGTTTCACCCTGGCCGGGGATTAGGAGGTCCTCGTGCTCGTAGATCAAACATGCACTTTACT AGCAGTTCTACTGGTGGACTTTCTTCTTCTCAGAGTTCATATTCTCCAAGCAATAGGGAAGCCATGGATCCTATAGCTGAGCTTTTATCT CAGTTATCAGGAGTGAGACGTTCTGCAGGAGGACAGCTTAATTCCTCTGGCCCTTCCGCTTCTCAGTTACAACAACTGCAGATGCAGCTG CAGCTAGAACGGCAGCATGCCCAGGCAGCACGGCAACAACTGGAGACCGCACGCAACGCAACCCGGCGTACTAACACAAGCAGTGTCACC ACTACAATCACACAATCCACAGCAACAACCAACATAGCTAATACAGAAAGCAGTCAGCAGACTCTACAGAATTCCCAGTTTCTTTTAACA AGGTTGAATGATCCTAAAATGTCTGAAACGGAGCGCCAGTCCATGGAAAGCGAGCGTGCAGACCGCAGCCTGTTTGTCCAAGAGCTCCTT CTGTCCACTTTAGTGCGTGAAGAGAGCTCATCCTCAGATGAGGATGATCGGGGGGAGATGGCAGATTTTGGTGCTATGGGCTGTGTAGAT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_GGCX_ENST00000233838_chr2_85787938_-_KCMF1_ENST00000409785_chr2_85255012_+_7488nt CGGAGCCTAGGGAAGCAAATTCTCCTGGCGGCCTCCGTTCAGACGCGGCAGCTGTGACCCACCTGCCTCCTCCGCAGAGCAATGGCGGTG TCTGCCGGGTCCGCGCGGACCTCGCCCAGCTCAGATAAAGTACAGAAAGACAAGGCTGAACTGATCTCAGGGCCCAGGCAGGACAGCCGA ATAGGGAAACTCTTGGGTTTTGAGTGGACAGATTTGTCCAGTTGGCGGAGGCTGGTGACCCTGCTGAATCGACCAACGGACCCTGCAAGC TTAGCTGTCTTTCGTTTTCTTTTTGGTGTCAGCTGTGATGCATGTTTAAAAGGAAATTTTCGAGGTCGCAGATATAAGTGTTTAATTTGC TACGATTACGATCTTTGTGCATCTTGTTATGAAAGTGGTGCAACAACAACAAGGCATACAACTGACCACCCAATGCAGTGCATATTAACA AGGGTAGATTTTGATTTATACTATGGTGGGGAAGCTTTCTCTGTAGAGCAGCCACAGTCTTTTACTTGTCCCTATTGTGGAAAAATGGGC TATACGGAGACATCTCTTCAAGAACATGTTACTTCTGAACATGCAGAAACATCAACAGAAGTGATTTGTCCAATATGTGCAGCGTTACCT GGAGGCGATCCTAATCATGTCACGGATGACTTTGCAGCTCATCTTACACTTGAACACAGAGCCCCTAGAGATTTAGATGAATCGAGTGGT GTTCGACATGTACGTAGAATGTTTCACCCTGGCCGGGGATTAGGAGGTCCTCGTGCTCGTAGATCAAACATGCACTTTACTAGCAGTTCT ACTGGTGGACTTTCTTCTTCTCAGAGTTCATATTCTCCAAGCAATAGGGAAGCCATGGATCCTATAGCTGAGCTTTTATCTCAGTTATCA GGAGTGAGACGTTCTGCAGGAGGACAGCTTAATTCCTCTGGCCCTTCCGCTTCTCAGTTACAACAACTGCAGATGCAGCTGCAGCTAGAA CGGCAGCATGCCCAGGCAGCACGGCAACAACTGGAGACCGCACGCAACGCAACCCGGCGTACTAACACAAGCAGTGTCACCACTACAATC ACACAATCCACAGCAACAACCAACATAGCTAATACAGAAAGCAGTCAGCAGACTCTACAGAATTCCCAGTTTCTTTTAACAAGGTTGAAT GATCCTAAAATGTCTGAAACGGAGCGCCAGTCCATGGAAAGCGAGCGTGCAGACCGCAGCCTGTTTGTCCAAGAGCTCCTTCTGTCCACT TTAGTGCGTGAAGAGAGCTCATCCTCAGATGAGGATGATCGGGGGGAGATGGCAGATTTTGGTGCTATGGGCTGTGTAGATATTATGCCT TTAGATGTTGCTTTAGAAAACCTAAATTTAAAAGAGAGTAATAAAGGAAATGAGCCTCCACCACCTCCTCTTTGATGACATCCCAATTCG CAGACAATGTCCTCTGTGCTGTATTTGCCAATGAAAGTGGACAACAACTATCTTGGGTTTGTTTGGTGATTGTAATTTCAGGTCTGTCAC TCTTGTTACATTGTGTACATTCAAAAGGAAGAGAGAAAATATATATGATAATCATTTCCACTTAACTAATTTTTACTTCTAGCAGGTAAA TGTAGGTAGCAGTGCAGGGGTGATCTCTGCTTCCTGTACCTTGACATGCAAAAGGCTCTCCTAATACTCCACATTCAAACTGAAGAGGAA AATTGAAATCTCTAATGAAGCTGCTGTGTGTATTTATGAATATTAATGAATAAAAACTGCTTGGATGGTTTACCTTAACTACTGCATGAG GTTTTTTGCAGCGTGCATGAGTTTTAGTGACCTTGTTATTTAAGAAGTTAAATACAAGGAGTAAAACTTAAAAAAAAAATACAAAGCCCA AAGCTTTCCCAAACATTATTCAATGGTTACACGACGAAGTAGCTTTTGAATAATGTCTGCCTGAATCACCTTTCTTTGTGTGCCTCCTAC GCACAAAGCCAGCTCTGCAGTGGAATCTGGGGATTATAGCCGGGTGTGGCACTCCGCCCTGTGTGACTGTCCTGTCGCCCTGTTAGTCAT CTTGCCTGTGTGGAGCTCAGCCTGTCTCTTTAACTCATCTGTAGAAGACACACCAGTAAAGCTACTGTTGGAATCTGCTGCAGGGGCCTT TGTGTGCCCTAAAAACAAATCCTGTTCATGTTTGTTTAAAGTTTTTACTTTTTGTGGTTGTTTAAAATTTTTTCAATTGTTAAATATGTT TTATTCAGGTGTAGATGAATTTCATTTATTGACTGTTCAACAGAGTTAACCTGAATTATGTTGTCTTTGTTTTTAAAAATCTCACATTCT CAATCATATTTTGCATTATTTATGTATTTGCTTTGTAGTTTGCTGAGACAGATCAGTATCAGGGGAGCTTTGAGGATTTGCCTTCCCAGA TTTGTCAGTATATTACAACCAAATTCTTAATGCTAATTTTAGCACCTTTTATTTATTGGGTTTTTTCTGGCATAAAAAGTAAAGCCTTTT AATTGAATCATGCCACCTATATGCCTATATTATTAATCCTATGTGTAAAAAAAATGTACAGCTTTTTTTGGGTTTGTTTTGGGGTTTGGA AGGGCCGGGTTATTTTTTATTTCCTGTTTCAGTTTTTGTGCATAGACTTTCACAATAGCTCCAAGGCAGGGACAGCGGGTTTGGGGGTTG GGAGGGCAGTTTTTGGAATGTAAATTTAGGACTTTTAAAAAGGTGCGCACAGCTTCTGATAAATTTATAACTAGACTTAACCTAATCATG TCTCGTTCCAGTTCTCTTTTCTCTGAGCCCTTTTCAAAGTCTCCTCTCTTTCTCCTGTCATCCTTTTCCTTTCCTGTCCGTGTATCTCCG TTTCTTCAACATGACAAGCATACAGACTTGAACACCCCTCCGGTGTTCTTCCGAGAACTGTGAAGTCCATGTTCATCCAAATGTAACCAA AAAAGAAGTCACCCTACATGTCTGAAAAACTGTTGCTTCTCCTCTGAAACTTCAAACTCCAACGATTTCCAAATACAATAGCTTTGTTTT CTTTAGTTCTGTAATGGATAATGTTTAAAGGAAAACTTTACACCAGGCTTCTGGTTACACTAGAAGTCAAGCCCATTAGGGATTTTCATT TTTTTTCATTTGGTTGTTGAGAAGTTTCAAAAATCAGTTTTCAAGCTGTGGTCTTTCAAACACATCTGCACATAAGTCACACATTTCAAT AAAGCATTTTCAAGACTGTTGACCACTTGAATTTCTTTGGTGTTAGTGGATTAACCTAACCATTACTCTGAGATTTTATATCTCTAATCC AGTATTTTTTTTCTTTTTATGCTAAACATGGGAGATCCTGGTTTTGTGTGAATGCATTATTTTGGATGTGAGAAATAAATGCCAATTATA TGTACTTTCCCTTTTCTGCACAAATTCTGGGAAAATGTAAAAGCCTTCATTTTTTAACATGGTTTTAGGGAACAACTGTAAGTCCATTCA GAGCAGTTTAATTTAGATGATCACTTTTAACACTGCAGAAGACCTAAGGAGTCATAAGATTCCATCTCATGTAGAATACTGTATATTAAT TATTTTTTACCAGATATTTTACAAATACCTCACCTCATCCTGTATGTAATCAATAATGTATTATTTTAGGGTAGAACGACACAGAATATC AATATAAAAATATATTCAAGCCCTTGAAATTCTTGTGTCCTTTTTCTTTAGTTTCTGAATGAAAATCTTATTACTGGATGTACTATTGAA TAAAAATTAATTGCAAAGACTTTGATGGAGACAAAATCAAAATATACCACTGTTTATTTTGGCAGCACCTTCAAATTTCTAAGGACCAGA TCCTGAATTTTGAGAATTTTTTGTTTCGTTGAGTTTTGAGTGTCTAGGATATAAGTTTATAAATGTTCTACAGTGCTTGTCTTTACTTCC TGTTTAGAAATCATTTAAATCTTTCCCCTCGAGGTGCTCTGGAAGAAGTTTAATTTCAGCTCTGAACAAGTAGAAATAACTGTGCTTCCT TGTATGGCTGCAATCATAAGACAGAATTTCTGTGGTTGGCTACCGTGAAATCTTTGTATTTATATTGCATTGTTTTGTTAAAAAAAAAAA AATCCACAGAAGTAGAACCTAGGTTTGCTACTAACAAAGTAGTGGATTCTTATAATTAGGCTCAGGTAAAGTAAGAGAAAACTTCTCTCC CTGTGGCCCCCAGAGAAATGAAGTAGGATAGCAGATTACACTATTAGAAATAATAGACGTAACAAAAAAAATCCAGCCCATTATCCCCAC CCCCCATTTTCCCTCTCAATATTAGAAATTTCAATAATATGCTGACAGATTTTCAAAGGTCACCAAGGCTTTTGTGTTTTTTTCCGGTCT GTGGGCCACAGTTAAAAGAACGGGTAACAGGTTCAGAGTTCTCTTGATACGTCCAAGCCTTAGTTTCCAGGAAAAAAGCTAGGCTCCTCA CTGCAAATATTAACGCTTTATATATTTACTCCATGGATGTTGGGGTAAGCACATATATCAATAGTTCATAGCTCTAGTTAAGGACAAAGT GGGTTGGGGGGTAGAAGGAGAATACTAGAGAGGTTACGGTAGCAGGTGGCTGCAGAAAAGAATCTTTTGAATGGGATTCCTGTAACAGTG TTCAGTACCAATATTAAGTCTACTGTAAGTGGGGTCTGATATGGCTTACTGATACAGGCATGTGTAAAAAACTAAGTGTGATGGAGGAAT GGGTGCTAAAAGCTCTTAACAGTTTTGTAGAGAAGCCCTGCAGCCGTGTTTACTATATATGACATGCCTGTTTCTTAGTTTGCATGCACA GTTTAAGGGGCACATGCAATATTGGTTTCATGTGCAGTAAAAATTAAAACACGGCTGAGCGTGGTGGCTCACGCCTGTAATCCCAGCACT TTGCGAGGCCGAGGCGGGTGGATCACGAGGTCGAGTTTGAGACCATTTTGGCCAGCATAGTGAAACCCCATCTCTACTAAAAAATACAAA AAGTTAGCTGGGCATGGTGGCAGGCACCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGGAGGCAGAGGT TGCAGTGAGCTGAGATCACGCCGCCATTGCACTCCAGCCCGGGCGACGGTGCAAGACTCTGTCTCAAAAAAAAAAAAAATTAAAACACTA GGTACGAAATTATCCCAGAATTATACGCGAAAGTTGGTGTTCATGCTGGAAAACAGTTACGGTTATCTGTGCTCTTTCTAAAGCTCAACT AGACACTAAAACAGTTCTCTCCTTGAGACCGGAAGTGGGATGGGGGTGGGCAGGTGGAAGGGAAGAGGCTGGGGAGGAGCCTCTCATCTC ATCTCATTTCAGCCTCAACAGTAATTGAAACCCTATGCCTGGCCTGGAGTGGGTAGAGGTTAGGGTTAGAGTGCAGGATGGAGCAGCAGT CTGCAGACTTTCAGGTTGTGACGATGTCATGAAATTCTGTGCTATTAAACATGGCTATGTCTGAGTCAGTCATTACGGTATTCCAAAGCC AAATTCAAGTGACTGTTTTTCTGAATAGTATAAAAATCTAATTCCCTGTGCTTATCGGCTTCAACTGTGCTTACACAACGTTTGTTTCTA ATTCGTACTCTTGCCTCTTGGTTTCTGTAGTTTTTCAACCCATTTCTGTCAGTGTTCTATAAATGCATACATTCGTTATTTAAGGAACCC TGCAGCAGACCTCGAATAAAATGTGACTTGATGTTTGTTGCCACTTCCTCAACTTGGTTAGCAAATTCAAGTTTTGAAAGACGATTCGTC TCAGAGAAGTTGATCCTGAACCTCCACGTCACATTTTAGTCGGTTGCTATTAGGTGGGTAATGCCTAATAACATGGGTTCCTCAAATCAC AAAGGAGAATGCTCTCAAGTCCTCATGTTAACTTTAGTAAGTCAGTTAACTTTACAGCAACTAAAGAGATCAATTAAAAAGAACCCTTAA GTCTGACTGTCCCAGGTAACTTTACTTGCTGTACAGATAGTGCACAGATATGGATGAGGGCTGCACATGGCTGATTTGAAAACCCATGTG GGGCCGGGTGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTGGATCACGAGGTTAGTTCAGGACCAGCCTGGC CAAGATGGTGAAACCCCATCTCTACTAAAAATACGAAAATTAGCTGGGCTTGGTGGCAGATGCCTGTAATTCCTGCTACTCGGGAGGCTG AGGCAGAGAATTGCTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCCGAGATTGCGCCACTGCACTCCAGCCTGGGCGACACAGTGAGACT CTCCTCAAAACAAAAAAAAAAGAAAGAAAACCCATGTGGGCCGCATGTGCACAGCCTGGGGCTGCTTTCCACAGGCCTGGATAATGATGT TTCTCTTCAAGGAGGCCTTTACTAACCACAGGGAACCTAGCATCTGACTGTGTCCTTGGCAGACAGTGCATGTAGCCTGTAGAATGTTGG CTCCTCTGTCTATAGAAACCATCAGTTCGCTGCTCTCTCATTCATACATACTTTTTGAGTTCCCAGTAGGTACGAAGCTTTGTCTAAACA TTATTTACCAACTGCGATTTTTACAGACTTCCCCTGTAAGAATTTTCTAAAAGAGCCTTTCTCCCTTACACAATTGAAACGTTTTCAAAG GTCATCAAGCCGGTTGCGTTTGGTCAGTCACGTGACCAATCAGAGCTGGTGAGTGAGCTGCTCCCTTAAATCTACCAAATTAGACTGACA GCATTTGGAATCTGCCTCACACATAAGAGATCCATATTCATTTAATAGTGAAGCCAGCCCAGAAGCATCCTCTTCTGTAAGCTGGATGGA GTCCCAGCTCTCTCTCCTTGTATATAAGGAGACCACACCCTGTATATAAGGTTTTCTTGAGGTAGATGCAGCAATATTCCTGGGGTAAGA TTCTATAATACTCCTGTATTGGCAAGTGGACTGGACCAACAGACACAGGCCTCAGCCACTGTCGCTAGGGACTGAAGGAGAGTTCATGGA TTCTTACCCCCTAGTCATGAAAGCTATTCTGGCCAGCCTTGAATCCATTTAATTTTGCCCACGAGAACCTTTCATGACAATTAACAAGAC ACTAGTTTCCCCATAAAAGTCCATTTTTAAATATATAGTATGCTAATTAGCAGTGTCTGTTGAATTGCCCTATCGGATAGCAGCCACCAT GTGTGCTGACCACTCACGATTCAGACTTACCTTGGAAAATATCACACTGACGATACAGTACTTTAGAATAAATTGCATATTGTATCAGGC TCCGAGACTAATTTGTACTGAACCCTTGATATAGATTACCTTTTATAACATCACCACCTGTCATGAAGCTTATCTGTTTTCTGATTTGAA |
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FusionGenePPI for GGCX_KCMF1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| GGCX | FBXO6, DCP2, SRPK2, FGD1, AP1S2, TERF2IP, FAM46A, TMCO3, TRIM25 | KCMF1 | GRK5, VCP, SOX2, BYSL, EIF3L, FLNC, HDLBP, HERC1, IKBKG, PNO1, PSMC1, PSMC5, PSMD11, PSMD12, PSMD13, PSMD3, PSMD7, PSMD8, RPS13, TJP2, TXNL1, UBR4, UCHL5, WDR26, WIBG, KCMF1, UBE2D2, UBC, FIGF, TFDP3, ABHD10, SARS2, IDH2, CEP85, NIPSNAP3A, MRS2, TESPA1, POGLUT1, EDA, CHIA, CD96, CST9, RASSF9, RASSF10, UBE2A, UBE2B, NIPSNAP1, SSBP1, ACOT9, NUP188, OGT, NUP93, NUP214, PRCP, QARS, HSPB1, KRAS, MED20, XPO1, POU5F1, A1BG, FSTL4, C15orf27, VWA5A, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GGCX_KCMF1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | GGCX | P38435 | DB00036 | Coagulation factor VIIa Recombinant Human | Vitamin K-dependent gamma-carboxylase | biotech | approved |
| Hgene | GGCX | P38435 | DB00100 | Coagulation Factor IX (Recombinant) | Vitamin K-dependent gamma-carboxylase | biotech | approved|investigational |
| Hgene | GGCX | P38435 | DB01022 | Phylloquinone | Vitamin K-dependent gamma-carboxylase | small molecule | approved|investigational |
| Hgene | GGCX | P38435 | DB00055 | Drotrecogin alfa | Vitamin K-dependent gamma-carboxylase | biotech | approved|investigational|withdrawn |
| Hgene | GGCX | P38435 | DB00142 | Glutamic Acid | Vitamin K-dependent gamma-carboxylase | small molecule | approved|nutraceutical |
| Hgene | GGCX | P38435 | DB00170 | Menadione | Vitamin K-dependent gamma-carboxylase | small molecule | approved|nutraceutical |
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RelatedDiseases for GGCX_KCMF1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | GGCX | C1848534 | VITAMIN K-DEPENDENT CLOTTING FACTORS, COMBINED DEFICIENCY OF, 1 | 4 | CTD_human;ORPHANET;UNIPROT |
| Hgene | GGCX | C0005779 | Blood Coagulation Disorders | 1 | CTD_human |
| Hgene | GGCX | C1835813 | Pseudoxanthoma Elasticum-Like Disorder with Multiple Coagulation Factor Deficiency | 1 | CTD_human;ORPHANET;UNIPROT |
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