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Fusion gene ID: 14546 |
FusionGeneSummary for GDNF_FYB |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GDNF_FYB | Fusion gene ID: 14546 | Hgene | Tgene | Gene symbol | GDNF | FYB | Gene ID | 2668 |
| Gene name | glial cell derived neurotrophic factor | ||
| Synonyms | ATF|ATF1|ATF2|HFB1-GDNF|HSCR3 | ||
| Cytomap | 5p13.2 | ||
| Type of gene | protein-coding | ||
| Description | glial cell line-derived neurotrophic factorastrocyte-derived trophic factor | ||
| Modification date | 20180519 | ||
| UniProtAcc | P39905 | ||
| Ensembl transtripts involved in fusion gene | ENST00000344622, ENST00000326524, ENST00000381826, ENST00000427982, ENST00000515058, | ENST00000351578, ENST00000515010, ENST00000505428, ENST00000512982, ENST00000540520, ENST00000503065, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 7 X 7 X 5=245 |
| # samples | 1 | 8 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(8/245*10)=-1.61470984411521 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: GDNF [Title/Abstract] AND FYB [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | GDNF | GO:0001755 | neural crest cell migration | 15242795 |
| Hgene | GDNF | GO:0008284 | positive regulation of cell proliferation | 22897442 |
| Hgene | GDNF | GO:0031175 | neuron projection development | 15242795 |
| Hgene | GDNF | GO:0032770 | positive regulation of monooxygenase activity | 12358785 |
| Hgene | GDNF | GO:0043524 | negative regulation of neuron apoptotic process | 8493557 |
| Hgene | GDNF | GO:0045944 | positive regulation of transcription by RNA polymerase II | 12358785 |
| Hgene | GDNF | GO:0048255 | mRNA stabilization | 12358785 |
| Hgene | GDNF | GO:0051584 | regulation of dopamine uptake involved in synaptic transmission | 8493557 |
| Hgene | GDNF | GO:0072107 | positive regulation of ureteric bud formation | 8657307 |
| Hgene | GDNF | GO:0090190 | positive regulation of branching involved in ureteric bud morphogenesis | 8657307|17229286 |
| Hgene | GDNF | GO:2001240 | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand | 10921886 |