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Fusion gene ID: 14488

FusionGeneSummary for GBF1_NOLC1

Fusion gene summary

Fusion gene information	Fusion gene name: GBF1_NOLC1
	Fusion gene ID: 14488
		Hgene	Tgene
	Gene symbol	GBF1	NOLC1
	Gene ID	80142	9221
	Gene name	prostaglandin E synthase 2	nucleolar and coiled-body phosphoprotein 1
	Synonyms	C9orf15\|GBF-1\|GBF1\|PGES2\|mPGES-2	NOPP130\|NOPP140\|NS5ATP13\|P130
	Cytomap	9q34.11	10q24.32
	Type of gene	protein-coding	protein-coding
	Description	prostaglandin E synthase 2GATE-binding factor 1gamma-interferon-activated transcriptional element-binding factor 1mPGE synthase-2membrane-associated prostaglandin E synthase 2microsomal prostaglandin E synthase-2prostaglandin-H(2) E-isomerase	nucleolar and coiled-body phosphoprotein 1140 kDa nucleolar phosphoproteinHCV NS5A trans-regulated protein 13HCV NS5A-transactivated protein 13hepatitis C virus NS5A-transactivated protein 13nucleolar 130 kDa proteinnucleolar and coiled-body phosphp
	Modification date	20180519	20180523
	UniProtAcc	Q92538	Q14978
	Ensembl transtripts involved in fusion gene	ENST00000369983, ENST00000476019,	ENST00000605788, ENST00000405356, ENST00000603742, ENST00000488254, ENST00000477977,
Fusion gene scores	* DoF score	11 X 7 X 8=616	3 X 3 X 2=18
	# samples	12	4
	** MAII score	log2(12/616*10)=-2.35989594508638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: GBF1 [Title/Abstract] AND NOLC1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	ACC	TCGA-OR-A5LO-01A	GBF1	chr10	104130617	+	NOLC1	chr10	103918950	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000369983	ENST00000605788	GBF1	chr10	104130617	+	NOLC1	chr10	103918950	+
Frame-shift	ENST00000369983	ENST00000405356	GBF1	chr10	104130617	+	NOLC1	chr10	103918950	+
5CDS-5UTR	ENST00000369983	ENST00000603742	GBF1	chr10	104130617	+	NOLC1	chr10	103918950	+
5CDS-5UTR	ENST00000369983	ENST00000488254	GBF1	chr10	104130617	+	NOLC1	chr10	103918950	+
5CDS-intron	ENST00000369983	ENST00000477977	GBF1	chr10	104130617	+	NOLC1	chr10	103918950	+
intron-3CDS	ENST00000476019	ENST00000605788	GBF1	chr10	104130617	+	NOLC1	chr10	103918950	+
intron-3CDS	ENST00000476019	ENST00000405356	GBF1	chr10	104130617	+	NOLC1	chr10	103918950	+
intron-5UTR	ENST00000476019	ENST00000603742	GBF1	chr10	104130617	+	NOLC1	chr10	103918950	+
intron-5UTR	ENST00000476019	ENST00000488254	GBF1	chr10	104130617	+	NOLC1	chr10	103918950	+
intron-intron	ENST00000476019	ENST00000477977	GBF1	chr10	104130617	+	NOLC1	chr10	103918950	+

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FusionProtFeatures for GBF1_NOLC1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GBF1 Q92538	NOLC1 Q14978

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Fusion gene ID: 14488

FusionGeneSummary for GBF1_NOLC1

FusionProtFeatures for GBF1_NOLC1