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Fusion gene ID: 14457 |
FusionGeneSummary for GATAD2B_NENF |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GATAD2B_NENF | Fusion gene ID: 14457 | Hgene | Tgene | Gene symbol | GATAD2B | NENF | Gene ID | 57459 | 29937 |
| Gene name | GATA zinc finger domain containing 2B | neudesin neurotrophic factor | |
| Synonyms | MRD18|P66beta|p68 | CIR2|SCIRP10|SPUF | |
| Cytomap | 1q21.3 | 1q32.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transcriptional repressor p66-betaGATA zinc finger domain-containing protein 2Btranscription repressor p66 beta component of the MeCP1 complex | neudesinSCIRP10-related proteinSpinal cord injury related protein 10cell growth-inhibiting protein 47cell immortalization-related protein 2neuron-derived neurotrophic factorsecreted protein of unknown function | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q8WXI9 | Q9UMX5 | |
| Ensembl transtripts involved in fusion gene | ENST00000368655, | ENST00000366988, ENST00000473900, | |
| Fusion gene scores | * DoF score | 23 X 6 X 12=1656 | 1 X 1 X 1=1 |
| # samples | 25 | 1 | |
| ** MAII score | log2(25/1656*10)=-2.72770267283724 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: GATAD2B [Title/Abstract] AND NENF [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PRAD | TCGA-CH-5766-01A | GATAD2B | chr1 | 153895209 | - | NENF | chr1 | 212615907 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000368655 | ENST00000366988 | GATAD2B | chr1 | 153895209 | - | NENF | chr1 | 212615907 | + |
| 5UTR-3UTR | ENST00000368655 | ENST00000473900 | GATAD2B | chr1 | 153895209 | - | NENF | chr1 | 212615907 | + |
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FusionProtFeatures for GATAD2B_NENF |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GATAD2B | NENF |