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Fusion gene ID: 14443

FusionGeneSummary for GATAD2A_ZNF93

Fusion gene summary

Fusion gene information	Fusion gene name: GATAD2A_ZNF93
	Fusion gene ID: 14443
		Hgene	Tgene
	Gene symbol	GATAD2A	ZNF93
	Gene ID	54815	81931
	Gene name	GATA zinc finger domain containing 2A	zinc finger protein 93
	Synonyms	p66alpha	HPF34\|HTF34\|TF34\|ZNF505
	Cytomap	19p13.11	19p12
	Type of gene	protein-coding	protein-coding
	Description	transcriptional repressor p66-alphaGATA zinc finger domain-containing protein 2A	zinc finger protein 93zinc finger protein 505zinc finger protein HTF34
	Modification date	20180523	20180522
	UniProtAcc	Q86YP4	P35789
	Ensembl transtripts involved in fusion gene	ENST00000252577, ENST00000360315, ENST00000537887, ENST00000404158, ENST00000358713, ENST00000429563, ENST00000473184,	ENST00000592613, ENST00000591366, ENST00000592160, ENST00000343769,
Fusion gene scores	* DoF score	13 X 8 X 9=936	3 X 2 X 3=18
	# samples	15	3
	** MAII score	log2(15/936*10)=-2.64154602908752 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: GATAD2A [Title/Abstract] AND ZNF93 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	GATAD2A	GO:0045892	negative regulation of transcription, DNA-templated	12183469
Tgene	ZNF93	GO:0045892	negative regulation of transcription, DNA-templated	25274305
Tgene	ZNF93	GO:0070895	negative regulation of transposon integration	25274305

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	OV	TCGA-09-1667-01C	GATAD2A	chr19	19516828	+	ZNF93	chr19	20043991	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000252577	ENST00000592613	GATAD2A	chr19	19516828	+	ZNF93	chr19	20043991	+
intron-intron	ENST00000252577	ENST00000591366	GATAD2A	chr19	19516828	+	ZNF93	chr19	20043991	+
intron-intron	ENST00000252577	ENST00000592160	GATAD2A	chr19	19516828	+	ZNF93	chr19	20043991	+
intron-intron	ENST00000252577	ENST00000343769	GATAD2A	chr19	19516828	+	ZNF93	chr19	20043991	+
intron-intron	ENST00000360315	ENST00000592613	GATAD2A	chr19	19516828	+	ZNF93	chr19	20043991	+
intron-intron	ENST00000360315	ENST00000591366	GATAD2A	chr19	19516828	+	ZNF93	chr19	20043991	+
intron-intron	ENST00000360315	ENST00000592160	GATAD2A	chr19	19516828	+	ZNF93	chr19	20043991	+
intron-intron	ENST00000360315	ENST00000343769	GATAD2A	chr19	19516828	+	ZNF93	chr19	20043991	+
intron-intron	ENST00000537887	ENST00000592613	GATAD2A	chr19	19516828	+	ZNF93	chr19	20043991	+
intron-intron	ENST00000537887	ENST00000591366	GATAD2A	chr19	19516828	+	ZNF93	chr19	20043991	+
intron-intron	ENST00000537887	ENST00000592160	GATAD2A	chr19	19516828	+	ZNF93	chr19	20043991	+
intron-intron	ENST00000537887	ENST00000343769	GATAD2A	chr19	19516828	+	ZNF93	chr19	20043991	+
intron-intron	ENST00000404158	ENST00000592613	GATAD2A	chr19	19516828	+	ZNF93	chr19	20043991	+
intron-intron	ENST00000404158	ENST00000591366	GATAD2A	chr19	19516828	+	ZNF93	chr19	20043991	+
intron-intron	ENST00000404158	ENST00000592160	GATAD2A	chr19	19516828	+	ZNF93	chr19	20043991	+
intron-intron	ENST00000404158	ENST00000343769	GATAD2A	chr19	19516828	+	ZNF93	chr19	20043991	+
intron-intron	ENST00000358713	ENST00000592613	GATAD2A	chr19	19516828	+	ZNF93	chr19	20043991	+
intron-intron	ENST00000358713	ENST00000591366	GATAD2A	chr19	19516828	+	ZNF93	chr19	20043991	+
intron-intron	ENST00000358713	ENST00000592160	GATAD2A	chr19	19516828	+	ZNF93	chr19	20043991	+
intron-intron	ENST00000358713	ENST00000343769	GATAD2A	chr19	19516828	+	ZNF93	chr19	20043991	+
intron-intron	ENST00000429563	ENST00000592613	GATAD2A	chr19	19516828	+	ZNF93	chr19	20043991	+
intron-intron	ENST00000429563	ENST00000591366	GATAD2A	chr19	19516828	+	ZNF93	chr19	20043991	+
intron-intron	ENST00000429563	ENST00000592160	GATAD2A	chr19	19516828	+	ZNF93	chr19	20043991	+
intron-intron	ENST00000429563	ENST00000343769	GATAD2A	chr19	19516828	+	ZNF93	chr19	20043991	+
intron-intron	ENST00000473184	ENST00000592613	GATAD2A	chr19	19516828	+	ZNF93	chr19	20043991	+
intron-intron	ENST00000473184	ENST00000591366	GATAD2A	chr19	19516828	+	ZNF93	chr19	20043991	+
intron-intron	ENST00000473184	ENST00000592160	GATAD2A	chr19	19516828	+	ZNF93	chr19	20043991	+
intron-intron	ENST00000473184	ENST00000343769	GATAD2A	chr19	19516828	+	ZNF93	chr19	20043991	+

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FusionProtFeatures for GATAD2A_ZNF93

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GATAD2A Q86YP4	ZNF93 P35789

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Fusion gene ID: 14443

FusionGeneSummary for GATAD2A_ZNF93

FusionProtFeatures for GATAD2A_ZNF93