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Fusion gene ID: 14409 |
FusionGeneSummary for GAS7_CHMP4A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GAS7_CHMP4A | Fusion gene ID: 14409 | Hgene | Tgene | Gene symbol | GAS7 | CHMP4A | Gene ID | 8522 | 128866 |
| Gene name | growth arrest specific 7 | charged multivesicular body protein 4B | |
| Synonyms | - | C20orf178|CHMP4A|CTPP3|CTRCT31|SNF7|SNF7-2|Shax1|VPS32B|Vps32-2|dJ553F4.4 | |
| Cytomap | 17p13.1 | 20q11.22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | growth arrest-specific protein 7 | charged multivesicular body protein 4bSNF7 homolog associated with Alix 1Snf7 homologue associated with Alix 1chromatin modifying protein 4Bchromatin-modifying protein 4bhSnf7-2hVps32-2vacuolar protein-sorting-associated protein 32-2 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | O60861 | Q9BY43 | |
| Ensembl transtripts involved in fusion gene | ENST00000437099, ENST00000323816, ENST00000432992, ENST00000540214, ENST00000585266, ENST00000580865, ENST00000583882, ENST00000542249, ENST00000396115, ENST00000579158, ENST00000578655, | ENST00000347519, ENST00000530996, ENST00000542700, ENST00000609024, | |
| Fusion gene scores | * DoF score | 10 X 7 X 6=420 | 1 X 1 X 1=1 |
| # samples | 12 | 1 | |
| ** MAII score | log2(12/420*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: GAS7 [Title/Abstract] AND CHMP4A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CHMP4A | GO:0039702 | viral budding via host ESCRT complex | 24878737 |
| Tgene | CHMP4A | GO:0051260 | protein homooligomerization | 18209100 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | GBM | TCGA-06-2562-01A | GAS7 | chr17 | 9923094 | - | CHMP4A | chr14 | 24681035 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000437099 | ENST00000347519 | GAS7 | chr17 | 9923094 | - | CHMP4A | chr14 | 24681035 | - |
| 5CDS-5UTR | ENST00000437099 | ENST00000530996 | GAS7 | chr17 | 9923094 | - | CHMP4A | chr14 | 24681035 | - |
| 5CDS-5UTR | ENST00000437099 | ENST00000542700 | GAS7 | chr17 | 9923094 | - | CHMP4A | chr14 | 24681035 | - |
| 5CDS-5UTR | ENST00000437099 | ENST00000609024 | GAS7 | chr17 | 9923094 | - | CHMP4A | chr14 | 24681035 | - |
| In-frame | ENST00000323816 | ENST00000347519 | GAS7 | chr17 | 9923094 | - | CHMP4A | chr14 | 24681035 | - |
| 5CDS-5UTR | ENST00000323816 | ENST00000530996 | GAS7 | chr17 | 9923094 | - | CHMP4A | chr14 | 24681035 | - |
| 5CDS-5UTR | ENST00000323816 | ENST00000542700 | GAS7 | chr17 | 9923094 | - | CHMP4A | chr14 | 24681035 | - |
| 5CDS-5UTR | ENST00000323816 | ENST00000609024 | GAS7 | chr17 | 9923094 | - | CHMP4A | chr14 | 24681035 | - |
| In-frame | ENST00000432992 | ENST00000347519 | GAS7 | chr17 | 9923094 | - | CHMP4A | chr14 | 24681035 | - |
| 5CDS-5UTR | ENST00000432992 | ENST00000530996 | GAS7 | chr17 | 9923094 | - | CHMP4A | chr14 | 24681035 | - |
| 5CDS-5UTR | ENST00000432992 | ENST00000542700 | GAS7 | chr17 | 9923094 | - | CHMP4A | chr14 | 24681035 | - |
| 5CDS-5UTR | ENST00000432992 | ENST00000609024 | GAS7 | chr17 | 9923094 | - | CHMP4A | chr14 | 24681035 | - |
| Frame-shift | ENST00000540214 | ENST00000347519 | GAS7 | chr17 | 9923094 | - | CHMP4A | chr14 | 24681035 | - |
| 5CDS-5UTR | ENST00000540214 | ENST00000530996 | GAS7 | chr17 | 9923094 | - | CHMP4A | chr14 | 24681035 | - |
| 5CDS-5UTR | ENST00000540214 | ENST00000542700 | GAS7 | chr17 | 9923094 | - | CHMP4A | chr14 | 24681035 | - |
| 5CDS-5UTR | ENST00000540214 | ENST00000609024 | GAS7 | chr17 | 9923094 | - | CHMP4A | chr14 | 24681035 | - |
| In-frame | ENST00000585266 | ENST00000347519 | GAS7 | chr17 | 9923094 | - | CHMP4A | chr14 | 24681035 | - |
| 5CDS-5UTR | ENST00000585266 | ENST00000530996 | GAS7 | chr17 | 9923094 | - | CHMP4A | chr14 | 24681035 | - |
| 5CDS-5UTR | ENST00000585266 | ENST00000542700 | GAS7 | chr17 | 9923094 | - | CHMP4A | chr14 | 24681035 | - |
| 5CDS-5UTR | ENST00000585266 | ENST00000609024 | GAS7 | chr17 | 9923094 | - | CHMP4A | chr14 | 24681035 | - |
| intron-3CDS | ENST00000580865 | ENST00000347519 | GAS7 | chr17 | 9923094 | - | CHMP4A | chr14 | 24681035 | - |
| intron-5UTR | ENST00000580865 | ENST00000530996 | GAS7 | chr17 | 9923094 | - | CHMP4A | chr14 | 24681035 | - |
| intron-5UTR | ENST00000580865 | ENST00000542700 | GAS7 | chr17 | 9923094 | - | CHMP4A | chr14 | 24681035 | - |
| intron-5UTR | ENST00000580865 | ENST00000609024 | GAS7 | chr17 | 9923094 | - | CHMP4A | chr14 | 24681035 | - |
| intron-3CDS | ENST00000583882 | ENST00000347519 | GAS7 | chr17 | 9923094 | - | CHMP4A | chr14 | 24681035 | - |
| intron-5UTR | ENST00000583882 | ENST00000530996 | GAS7 | chr17 | 9923094 | - | CHMP4A | chr14 | 24681035 | - |
| intron-5UTR | ENST00000583882 | ENST00000542700 | GAS7 | chr17 | 9923094 | - | CHMP4A | chr14 | 24681035 | - |
| intron-5UTR | ENST00000583882 | ENST00000609024 | GAS7 | chr17 | 9923094 | - | CHMP4A | chr14 | 24681035 | - |
| Frame-shift | ENST00000542249 | ENST00000347519 | GAS7 | chr17 | 9923094 | - | CHMP4A | chr14 | 24681035 | - |
| 5CDS-5UTR | ENST00000542249 | ENST00000530996 | GAS7 | chr17 | 9923094 | - | CHMP4A | chr14 | 24681035 | - |
| 5CDS-5UTR | ENST00000542249 | ENST00000542700 | GAS7 | chr17 | 9923094 | - | CHMP4A | chr14 | 24681035 | - |
| 5CDS-5UTR | ENST00000542249 | ENST00000609024 | GAS7 | chr17 | 9923094 | - | CHMP4A | chr14 | 24681035 | - |
| In-frame | ENST00000396115 | ENST00000347519 | GAS7 | chr17 | 9923094 | - | CHMP4A | chr14 | 24681035 | - |
| 5CDS-5UTR | ENST00000396115 | ENST00000530996 | GAS7 | chr17 | 9923094 | - | CHMP4A | chr14 | 24681035 | - |
| 5CDS-5UTR | ENST00000396115 | ENST00000542700 | GAS7 | chr17 | 9923094 | - | CHMP4A | chr14 | 24681035 | - |
| 5CDS-5UTR | ENST00000396115 | ENST00000609024 | GAS7 | chr17 | 9923094 | - | CHMP4A | chr14 | 24681035 | - |
| Frame-shift | ENST00000579158 | ENST00000347519 | GAS7 | chr17 | 9923094 | - | CHMP4A | chr14 | 24681035 | - |
| 5CDS-5UTR | ENST00000579158 | ENST00000530996 | GAS7 | chr17 | 9923094 | - | CHMP4A | chr14 | 24681035 | - |
| 5CDS-5UTR | ENST00000579158 | ENST00000542700 | GAS7 | chr17 | 9923094 | - | CHMP4A | chr14 | 24681035 | - |
| 5CDS-5UTR | ENST00000579158 | ENST00000609024 | GAS7 | chr17 | 9923094 | - | CHMP4A | chr14 | 24681035 | - |
| 5UTR-3CDS | ENST00000578655 | ENST00000347519 | GAS7 | chr17 | 9923094 | - | CHMP4A | chr14 | 24681035 | - |
| 5UTR-5UTR | ENST00000578655 | ENST00000530996 | GAS7 | chr17 | 9923094 | - | CHMP4A | chr14 | 24681035 | - |
| 5UTR-5UTR | ENST00000578655 | ENST00000542700 | GAS7 | chr17 | 9923094 | - | CHMP4A | chr14 | 24681035 | - |
| 5UTR-5UTR | ENST00000578655 | ENST00000609024 | GAS7 | chr17 | 9923094 | - | CHMP4A | chr14 | 24681035 | - |
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FusionProtFeatures for GAS7_CHMP4A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GAS7 | CHMP4A |