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Fusion gene ID: 1439 |
FusionGeneSummary for ALB_SERPING1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ALB_SERPING1 | Fusion gene ID: 1439 | Hgene | Tgene | Gene symbol | ALB | SERPING1 | Gene ID | 213 | 710 |
| Gene name | albumin | serpin family G member 1 | |
| Synonyms | HSA|PRO0883|PRO0903|PRO1341 | C1IN|C1INH|C1NH|HAE1|HAE2 | |
| Cytomap | 4q13.3 | 11q12.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serum albumin | plasma protease C1 inhibitorC1 esterase inhibitorC1-inhibiting factorcomplement component 1 inhibitorserine/cysteine proteinase inhibitor clade G member 1serpin G1serpin peptidase inhibitor clade G member 1serpin peptidase inhibitor, clade G (C1 in | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | P02768 | P05155 | |
| Ensembl transtripts involved in fusion gene | ENST00000295897, ENST00000415165, ENST00000503124, ENST00000509063, ENST00000401494, ENST00000505649, | ENST00000278407, ENST00000340687, ENST00000378323, ENST00000378324, ENST00000403558, ENST00000531605, | |
| Fusion gene scores | * DoF score | 19 X 15 X 3=855 | 6 X 6 X 2=72 |
| # samples | 25 | 7 | |
| ** MAII score | log2(25/855*10)=-1.77399632511117 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/72*10)=-0.0406419844973459 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ALB [Title/Abstract] AND SERPING1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ALB | GO:0009267 | cellular response to starvation | 16245148 |
| Hgene | ALB | GO:0019836 | hemolysis by symbiont of host erythrocytes | 16394536 |
| Hgene | ALB | GO:0043066 | negative regulation of apoptotic process | 16153637 |
| Hgene | ALB | GO:0051659 | maintenance of mitochondrion location | 16153637 |
| Tgene | SERPING1 | GO:0001869 | negative regulation of complement activation, lectin pathway | 10946292 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BP294362 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000295897 | ENST00000278407 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
| In-frame | ENST00000295897 | ENST00000340687 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
| Frame-shift | ENST00000295897 | ENST00000378323 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
| Frame-shift | ENST00000295897 | ENST00000378324 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
| Frame-shift | ENST00000295897 | ENST00000403558 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
| 5CDS-intron | ENST00000295897 | ENST00000531605 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
| intron-3CDS | ENST00000415165 | ENST00000278407 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
| intron-3CDS | ENST00000415165 | ENST00000340687 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
| intron-3CDS | ENST00000415165 | ENST00000378323 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
| intron-3CDS | ENST00000415165 | ENST00000378324 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
| intron-3CDS | ENST00000415165 | ENST00000403558 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
| intron-intron | ENST00000415165 | ENST00000531605 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
| intron-3CDS | ENST00000503124 | ENST00000278407 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
| intron-3CDS | ENST00000503124 | ENST00000340687 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
| intron-3CDS | ENST00000503124 | ENST00000378323 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
| intron-3CDS | ENST00000503124 | ENST00000378324 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
| intron-3CDS | ENST00000503124 | ENST00000403558 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
| intron-intron | ENST00000503124 | ENST00000531605 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
| Frame-shift | ENST00000509063 | ENST00000278407 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
| In-frame | ENST00000509063 | ENST00000340687 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
| Frame-shift | ENST00000509063 | ENST00000378323 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
| Frame-shift | ENST00000509063 | ENST00000378324 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
| Frame-shift | ENST00000509063 | ENST00000403558 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
| 5CDS-intron | ENST00000509063 | ENST00000531605 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
| intron-3CDS | ENST00000401494 | ENST00000278407 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
| intron-3CDS | ENST00000401494 | ENST00000340687 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
| intron-3CDS | ENST00000401494 | ENST00000378323 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
| intron-3CDS | ENST00000401494 | ENST00000378324 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
| intron-3CDS | ENST00000401494 | ENST00000403558 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
| intron-intron | ENST00000401494 | ENST00000531605 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
| 3UTR-3CDS | ENST00000505649 | ENST00000278407 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
| 3UTR-3CDS | ENST00000505649 | ENST00000340687 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
| 3UTR-3CDS | ENST00000505649 | ENST00000378323 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
| 3UTR-3CDS | ENST00000505649 | ENST00000378324 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
| 3UTR-3CDS | ENST00000505649 | ENST00000403558 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
| 3UTR-intron | ENST00000505649 | ENST00000531605 | ALB | chr4 | 74274476 | + | SERPING1 | chr11 | 57381845 | + |
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FusionProtFeatures for ALB_SERPING1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ALB | SERPING1 |