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Fusion gene ID: 14382

FusionGeneSummary for GAS2L1_EWSR1

Fusion gene summary

Fusion gene information	Fusion gene name: GAS2L1_EWSR1
	Fusion gene ID: 14382
		Hgene	Tgene
	Gene symbol	GAS2L1	EWSR1
	Gene ID	10634	2130
	Gene name	growth arrest specific 2 like 1	EWS RNA binding protein 1
	Synonyms	GAR22	EWS\|EWS-FLI1\|bK984G1.4
	Cytomap	22q12.2	22q12.2
	Type of gene	protein-coding	protein-coding
	Description	GAS2-like protein 1GAS2-related protein on chromosome 22growth arrest-specific protein 2-like 1	RNA-binding protein EWSEWS RNA-binding protein variant 6Ewing sarcoma breakpoint region 1Ewings sarcoma EWS-Fli1 (type 1) oncogene
	Modification date	20180519	20180527
	UniProtAcc	Q99501	Q01844
	Ensembl transtripts involved in fusion gene	ENST00000407647, ENST00000360113, ENST00000406549, ENST00000341313, ENST00000403764, ENST00000407854, ENST00000471961,	ENST00000332050, ENST00000397938, ENST00000406548, ENST00000331029, ENST00000414183, ENST00000333395, ENST00000332035,
Fusion gene scores	* DoF score	2 X 2 X 2=8	8 X 20 X 7=1120
	# samples	2	21
	** MAII score	log2(2/8*10)=1.32192809488736	log2(21/1120*10)=-2.41503749927884 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: GAS2L1 [Title/Abstract] AND EWSR1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	GAS2L1	GO:0097067	cellular response to thyroid hormone stimulus	19375645

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	KIRC	TCGA-AS-3777-01A	GAS2L1	chr22	29706988	+	EWSR1	chr22	29694723	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000407647	ENST00000332050	GAS2L1	chr22	29706988	+	EWSR1	chr22	29694723	+
Frame-shift	ENST00000407647	ENST00000397938	GAS2L1	chr22	29706988	+	EWSR1	chr22	29694723	+
Frame-shift	ENST00000407647	ENST00000406548	GAS2L1	chr22	29706988	+	EWSR1	chr22	29694723	+
Frame-shift	ENST00000407647	ENST00000331029	GAS2L1	chr22	29706988	+	EWSR1	chr22	29694723	+
Frame-shift	ENST00000407647	ENST00000414183	GAS2L1	chr22	29706988	+	EWSR1	chr22	29694723	+
5CDS-intron	ENST00000407647	ENST00000333395	GAS2L1	chr22	29706988	+	EWSR1	chr22	29694723	+
5CDS-intron	ENST00000407647	ENST00000332035	GAS2L1	chr22	29706988	+	EWSR1	chr22	29694723	+
intron-3CDS	ENST00000360113	ENST00000332050	GAS2L1	chr22	29706988	+	EWSR1	chr22	29694723	+
intron-3CDS	ENST00000360113	ENST00000397938	GAS2L1	chr22	29706988	+	EWSR1	chr22	29694723	+
intron-3CDS	ENST00000360113	ENST00000406548	GAS2L1	chr22	29706988	+	EWSR1	chr22	29694723	+
intron-3CDS	ENST00000360113	ENST00000331029	GAS2L1	chr22	29706988	+	EWSR1	chr22	29694723	+
intron-3CDS	ENST00000360113	ENST00000414183	GAS2L1	chr22	29706988	+	EWSR1	chr22	29694723	+
intron-intron	ENST00000360113	ENST00000333395	GAS2L1	chr22	29706988	+	EWSR1	chr22	29694723	+
intron-intron	ENST00000360113	ENST00000332035	GAS2L1	chr22	29706988	+	EWSR1	chr22	29694723	+
Frame-shift	ENST00000406549	ENST00000332050	GAS2L1	chr22	29706988	+	EWSR1	chr22	29694723	+
Frame-shift	ENST00000406549	ENST00000397938	GAS2L1	chr22	29706988	+	EWSR1	chr22	29694723	+
Frame-shift	ENST00000406549	ENST00000406548	GAS2L1	chr22	29706988	+	EWSR1	chr22	29694723	+
Frame-shift	ENST00000406549	ENST00000331029	GAS2L1	chr22	29706988	+	EWSR1	chr22	29694723	+
Frame-shift	ENST00000406549	ENST00000414183	GAS2L1	chr22	29706988	+	EWSR1	chr22	29694723	+
5CDS-intron	ENST00000406549	ENST00000333395	GAS2L1	chr22	29706988	+	EWSR1	chr22	29694723	+
5CDS-intron	ENST00000406549	ENST00000332035	GAS2L1	chr22	29706988	+	EWSR1	chr22	29694723	+
Frame-shift	ENST00000341313	ENST00000332050	GAS2L1	chr22	29706988	+	EWSR1	chr22	29694723	+
Frame-shift	ENST00000341313	ENST00000397938	GAS2L1	chr22	29706988	+	EWSR1	chr22	29694723	+
Frame-shift	ENST00000341313	ENST00000406548	GAS2L1	chr22	29706988	+	EWSR1	chr22	29694723	+
Frame-shift	ENST00000341313	ENST00000331029	GAS2L1	chr22	29706988	+	EWSR1	chr22	29694723	+
Frame-shift	ENST00000341313	ENST00000414183	GAS2L1	chr22	29706988	+	EWSR1	chr22	29694723	+
5CDS-intron	ENST00000341313	ENST00000333395	GAS2L1	chr22	29706988	+	EWSR1	chr22	29694723	+
5CDS-intron	ENST00000341313	ENST00000332035	GAS2L1	chr22	29706988	+	EWSR1	chr22	29694723	+
Frame-shift	ENST00000403764	ENST00000332050	GAS2L1	chr22	29706988	+	EWSR1	chr22	29694723	+
Frame-shift	ENST00000403764	ENST00000397938	GAS2L1	chr22	29706988	+	EWSR1	chr22	29694723	+
Frame-shift	ENST00000403764	ENST00000406548	GAS2L1	chr22	29706988	+	EWSR1	chr22	29694723	+
Frame-shift	ENST00000403764	ENST00000331029	GAS2L1	chr22	29706988	+	EWSR1	chr22	29694723	+
Frame-shift	ENST00000403764	ENST00000414183	GAS2L1	chr22	29706988	+	EWSR1	chr22	29694723	+
5CDS-intron	ENST00000403764	ENST00000333395	GAS2L1	chr22	29706988	+	EWSR1	chr22	29694723	+
5CDS-intron	ENST00000403764	ENST00000332035	GAS2L1	chr22	29706988	+	EWSR1	chr22	29694723	+
Frame-shift	ENST00000407854	ENST00000332050	GAS2L1	chr22	29706988	+	EWSR1	chr22	29694723	+
Frame-shift	ENST00000407854	ENST00000397938	GAS2L1	chr22	29706988	+	EWSR1	chr22	29694723	+
Frame-shift	ENST00000407854	ENST00000406548	GAS2L1	chr22	29706988	+	EWSR1	chr22	29694723	+
Frame-shift	ENST00000407854	ENST00000331029	GAS2L1	chr22	29706988	+	EWSR1	chr22	29694723	+
Frame-shift	ENST00000407854	ENST00000414183	GAS2L1	chr22	29706988	+	EWSR1	chr22	29694723	+
5CDS-intron	ENST00000407854	ENST00000333395	GAS2L1	chr22	29706988	+	EWSR1	chr22	29694723	+
5CDS-intron	ENST00000407854	ENST00000332035	GAS2L1	chr22	29706988	+	EWSR1	chr22	29694723	+
Frame-shift	ENST00000471961	ENST00000332050	GAS2L1	chr22	29706988	+	EWSR1	chr22	29694723	+
Frame-shift	ENST00000471961	ENST00000397938	GAS2L1	chr22	29706988	+	EWSR1	chr22	29694723	+
Frame-shift	ENST00000471961	ENST00000406548	GAS2L1	chr22	29706988	+	EWSR1	chr22	29694723	+
Frame-shift	ENST00000471961	ENST00000331029	GAS2L1	chr22	29706988	+	EWSR1	chr22	29694723	+
Frame-shift	ENST00000471961	ENST00000414183	GAS2L1	chr22	29706988	+	EWSR1	chr22	29694723	+
5CDS-intron	ENST00000471961	ENST00000333395	GAS2L1	chr22	29706988	+	EWSR1	chr22	29694723	+
5CDS-intron	ENST00000471961	ENST00000332035	GAS2L1	chr22	29706988	+	EWSR1	chr22	29694723	+

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FusionProtFeatures for GAS2L1_EWSR1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GAS2L1 Q99501	EWSR1 Q01844

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Fusion gene ID: 14382

FusionGeneSummary for GAS2L1_EWSR1

FusionProtFeatures for GAS2L1_EWSR1