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Fusion gene ID: 14374 |
FusionGeneSummary for GARS_DDX17 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GARS_DDX17 | Fusion gene ID: 14374 | Hgene | Tgene | Gene symbol | GARS | DDX17 | Gene ID | 2618 | 10521 |
| Gene name | phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase | DEAD-box helicase 17 | |
| Synonyms | AIRS|GARS|GARTF|PAIS|PGFT|PRGS | P72|RH70 | |
| Cytomap | 21q22.11 | 22q13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | trifunctional purine biosynthetic protein adenosine-3GAR transformylaseGARS-AIRS-GARTglycinamide ribonucleotide formyltransferaseglycinamide ribonucleotide synthetase-aminoimidazole ribonucleotide synthetase-glycinamide ribonucleotide transformylase | probable ATP-dependent RNA helicase DDX17DEAD (Asp-Glu-Ala-Asp) box helicase 17DEAD (Asp-Glu-Ala-Asp) box polypeptide 17DEAD box protein p72DEAD box protein p82DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 17 (72kD)RNA-dependent helicase p72 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | P41250 | Q92841 | |
| Ensembl transtripts involved in fusion gene | ENST00000389266, | ENST00000396821, ENST00000444597, ENST00000381633, ENST00000432525, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 12 X 14 X 3=504 |
| # samples | 3 | 14 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(14/504*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: GARS [Title/Abstract] AND DDX17 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | DDX17 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 17226766 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AI444651 | GARS | chr7 | 30673427 | - | DDX17 | chr22 | 38880108 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000389266 | ENST00000396821 | GARS | chr7 | 30673427 | - | DDX17 | chr22 | 38880108 | - |
| 5CDS-3UTR | ENST00000389266 | ENST00000444597 | GARS | chr7 | 30673427 | - | DDX17 | chr22 | 38880108 | - |
| 5CDS-3UTR | ENST00000389266 | ENST00000381633 | GARS | chr7 | 30673427 | - | DDX17 | chr22 | 38880108 | - |
| 5CDS-intron | ENST00000389266 | ENST00000432525 | GARS | chr7 | 30673427 | - | DDX17 | chr22 | 38880108 | - |
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FusionProtFeatures for GARS_DDX17 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GARS | DDX17 |