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Fusion gene ID: 14365 |
FusionGeneSummary for GAPDH_RPL23 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GAPDH_RPL23 | Fusion gene ID: 14365 | Hgene | Tgene | Gene symbol | GAPDH | RPL23 | Gene ID | 2597 | 9349 |
| Gene name | glyceraldehyde-3-phosphate dehydrogenase | ribosomal protein L23 | |
| Synonyms | G3PD|GAPD|HEL-S-162eP | L23|rpL17 | |
| Cytomap | 12p13.31 | 17q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | glyceraldehyde-3-phosphate dehydrogenaseOCAS, p38 componentOct1 coactivator in S phase, 38 Kd componentaging-associated gene 9 proteinepididymis secretory sperm binding protein Li 162ePpeptidyl-cysteine S-nitrosylase GAPDH | 60S ribosomal protein L2360S ribosomal protein L17large ribosomal subunit protein uL14ribosomal protein L17 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P04406 | P62829 | |
| Ensembl transtripts involved in fusion gene | ENST00000229239, ENST00000396856, ENST00000396861, ENST00000396859, ENST00000396858, | ENST00000394332, ENST00000394333, ENST00000479035, ENST00000245857, ENST00000577407, | |
| Fusion gene scores | * DoF score | 18 X 18 X 6=1944 | 10 X 9 X 5=450 |
| # samples | 26 | 15 | |
| ** MAII score | log2(26/1944*10)=-2.90244469057733 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(15/450*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: GAPDH [Title/Abstract] AND RPL23 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | GAPDH | GO:0010951 | negative regulation of endopeptidase activity | 22832495 |
| Hgene | GAPDH | GO:0017148 | negative regulation of translation | 23071094 |
| Hgene | GAPDH | GO:0031640 | killing of cells of other organism | 22832495 |
| Hgene | GAPDH | GO:0050715 | positive regulation of cytokine secretion | 22832495 |
| Hgene | GAPDH | GO:0050832 | defense response to fungus | 22832495 |
| Hgene | GAPDH | GO:0051873 | killing by host of symbiont cells | 22832495 |
| Hgene | GAPDH | GO:0052501 | positive regulation by organism of apoptotic process in other organism involved in symbiotic interaction | 22832495 |
| Hgene | GAPDH | GO:0061844 | antimicrobial humoral immune response mediated by antimicrobial peptide | 22832495 |
| Hgene | GAPDH | GO:0071346 | cellular response to interferon-gamma | 15479637 |
| Tgene | RPL23 | GO:0032986 | protein-DNA complex disassembly | 19160485 |
| Tgene | RPL23 | GO:1904667 | negative regulation of ubiquitin protein ligase activity | 15314173 |
| Tgene | RPL23 | GO:2000059 | negative regulation of ubiquitin-dependent protein catabolic process | 15314173 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DW440511 | GAPDH | chr12 | 6646535 | + | RPL23 | chr17 | 37009979 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000229239 | ENST00000394332 | GAPDH | chr12 | 6646535 | + | RPL23 | chr17 | 37009979 | - |
| 5CDS-5UTR | ENST00000229239 | ENST00000394333 | GAPDH | chr12 | 6646535 | + | RPL23 | chr17 | 37009979 | - |
| 5CDS-5UTR | ENST00000229239 | ENST00000479035 | GAPDH | chr12 | 6646535 | + | RPL23 | chr17 | 37009979 | - |
| 5CDS-intron | ENST00000229239 | ENST00000245857 | GAPDH | chr12 | 6646535 | + | RPL23 | chr17 | 37009979 | - |
| 5CDS-5UTR | ENST00000229239 | ENST00000577407 | GAPDH | chr12 | 6646535 | + | RPL23 | chr17 | 37009979 | - |
| In-frame | ENST00000396856 | ENST00000394332 | GAPDH | chr12 | 6646535 | + | RPL23 | chr17 | 37009979 | - |
| 5CDS-5UTR | ENST00000396856 | ENST00000394333 | GAPDH | chr12 | 6646535 | + | RPL23 | chr17 | 37009979 | - |
| 5CDS-5UTR | ENST00000396856 | ENST00000479035 | GAPDH | chr12 | 6646535 | + | RPL23 | chr17 | 37009979 | - |
| 5CDS-intron | ENST00000396856 | ENST00000245857 | GAPDH | chr12 | 6646535 | + | RPL23 | chr17 | 37009979 | - |
| 5CDS-5UTR | ENST00000396856 | ENST00000577407 | GAPDH | chr12 | 6646535 | + | RPL23 | chr17 | 37009979 | - |
| In-frame | ENST00000396861 | ENST00000394332 | GAPDH | chr12 | 6646535 | + | RPL23 | chr17 | 37009979 | - |
| 5CDS-5UTR | ENST00000396861 | ENST00000394333 | GAPDH | chr12 | 6646535 | + | RPL23 | chr17 | 37009979 | - |
| 5CDS-5UTR | ENST00000396861 | ENST00000479035 | GAPDH | chr12 | 6646535 | + | RPL23 | chr17 | 37009979 | - |
| 5CDS-intron | ENST00000396861 | ENST00000245857 | GAPDH | chr12 | 6646535 | + | RPL23 | chr17 | 37009979 | - |
| 5CDS-5UTR | ENST00000396861 | ENST00000577407 | GAPDH | chr12 | 6646535 | + | RPL23 | chr17 | 37009979 | - |
| In-frame | ENST00000396859 | ENST00000394332 | GAPDH | chr12 | 6646535 | + | RPL23 | chr17 | 37009979 | - |
| 5CDS-5UTR | ENST00000396859 | ENST00000394333 | GAPDH | chr12 | 6646535 | + | RPL23 | chr17 | 37009979 | - |
| 5CDS-5UTR | ENST00000396859 | ENST00000479035 | GAPDH | chr12 | 6646535 | + | RPL23 | chr17 | 37009979 | - |
| 5CDS-intron | ENST00000396859 | ENST00000245857 | GAPDH | chr12 | 6646535 | + | RPL23 | chr17 | 37009979 | - |
| 5CDS-5UTR | ENST00000396859 | ENST00000577407 | GAPDH | chr12 | 6646535 | + | RPL23 | chr17 | 37009979 | - |
| In-frame | ENST00000396858 | ENST00000394332 | GAPDH | chr12 | 6646535 | + | RPL23 | chr17 | 37009979 | - |
| 5CDS-5UTR | ENST00000396858 | ENST00000394333 | GAPDH | chr12 | 6646535 | + | RPL23 | chr17 | 37009979 | - |
| 5CDS-5UTR | ENST00000396858 | ENST00000479035 | GAPDH | chr12 | 6646535 | + | RPL23 | chr17 | 37009979 | - |
| 5CDS-intron | ENST00000396858 | ENST00000245857 | GAPDH | chr12 | 6646535 | + | RPL23 | chr17 | 37009979 | - |
| 5CDS-5UTR | ENST00000396858 | ENST00000577407 | GAPDH | chr12 | 6646535 | + | RPL23 | chr17 | 37009979 | - |
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FusionProtFeatures for GAPDH_RPL23 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GAPDH | RPL23 |