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Fusion gene ID: 14254 |
FusionGeneSummary for GABRP_RANBP17 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GABRP_RANBP17 | Fusion gene ID: 14254 | Hgene | Tgene | Gene symbol | GABRP | RANBP17 | Gene ID | 2568 | 64901 |
| Gene name | gamma-aminobutyric acid type A receptor pi subunit | RAN binding protein 17 | |
| Synonyms | - | - | |
| Cytomap | 5q35.1 | 5q35.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | gamma-aminobutyric acid receptor subunit piGABA(A) receptor subunit piGABA(A) receptor, pigamma-aminobutyric acid (GABA) A receptor, pi | ran-binding protein 17 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O00591 | Q9H2T7 | |
| Ensembl transtripts involved in fusion gene | ENST00000518525, ENST00000265294, ENST00000519385, ENST00000519598, | ENST00000523189, ENST00000521759, | |
| Fusion gene scores | * DoF score | 3 X 4 X 4=48 | 3 X 4 X 4=48 |
| # samples | 5 | 5 | |
| ** MAII score | log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: GABRP [Title/Abstract] AND RANBP17 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | STAD | TCGA-D7-A4YY-01A | GABRP | chr5 | 170216251 | + | RANBP17 | chr5 | 170380601 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000518525 | ENST00000523189 | GABRP | chr5 | 170216251 | + | RANBP17 | chr5 | 170380601 | + |
| 5CDS-intron | ENST00000518525 | ENST00000521759 | GABRP | chr5 | 170216251 | + | RANBP17 | chr5 | 170380601 | + |
| In-frame | ENST00000265294 | ENST00000523189 | GABRP | chr5 | 170216251 | + | RANBP17 | chr5 | 170380601 | + |
| 5CDS-intron | ENST00000265294 | ENST00000521759 | GABRP | chr5 | 170216251 | + | RANBP17 | chr5 | 170380601 | + |
| In-frame | ENST00000519385 | ENST00000523189 | GABRP | chr5 | 170216251 | + | RANBP17 | chr5 | 170380601 | + |
| 5CDS-intron | ENST00000519385 | ENST00000521759 | GABRP | chr5 | 170216251 | + | RANBP17 | chr5 | 170380601 | + |
| In-frame | ENST00000519598 | ENST00000523189 | GABRP | chr5 | 170216251 | + | RANBP17 | chr5 | 170380601 | + |
| 5CDS-intron | ENST00000519598 | ENST00000521759 | GABRP | chr5 | 170216251 | + | RANBP17 | chr5 | 170380601 | + |
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FusionProtFeatures for GABRP_RANBP17 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GABRP | RANBP17 |