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Fusion gene ID: 14248 |
FusionGeneSummary for GABRG2_SCD |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GABRG2_SCD | Fusion gene ID: 14248 | Hgene | Tgene | Gene symbol | GABRG2 | SCD | Gene ID | 2566 | 6319 |
| Gene name | gamma-aminobutyric acid type A receptor gamma2 subunit | stearoyl-CoA desaturase | |
| Synonyms | CAE2|ECA2|GEFSP3 | FADS5|MSTP008|SCD1|SCDOS|hSCD1 | |
| Cytomap | 5q34 | 10q24.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | gamma-aminobutyric acid receptor subunit gamma-2GABA(A) receptor subunit gamma-2GABA(A) receptor, gamma 2gamma-aminobutyric acid (GABA) A receptor, gamma 2 | acyl-CoA desaturasedelta(9)-desaturasefatty acid desaturasepredicted protein of HQ0998stearoyl-CoA desaturase (delta-9-desaturase)stearoyl-CoA desaturase opposite strand | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P18507 | O00767 | |
| Ensembl transtripts involved in fusion gene | ENST00000356592, ENST00000414552, ENST00000361925, ENST00000393933, | ENST00000370355, | |
| Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 7 X 7 X 3=147 |
| # samples | 2 | 7 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(7/147*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: GABRG2 [Title/Abstract] AND SCD [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SCD | GO:0006636 | unsaturated fatty acid biosynthetic process | 15907797|18765284 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AA985118 | GABRG2 | chr5 | 161582396 | - | SCD | chr10 | 102120947 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3UTR | ENST00000356592 | ENST00000370355 | GABRG2 | chr5 | 161582396 | - | SCD | chr10 | 102120947 | - |
| 3UTR-3UTR | ENST00000414552 | ENST00000370355 | GABRG2 | chr5 | 161582396 | - | SCD | chr10 | 102120947 | - |
| intron-3UTR | ENST00000361925 | ENST00000370355 | GABRG2 | chr5 | 161582396 | - | SCD | chr10 | 102120947 | - |
| intron-3UTR | ENST00000393933 | ENST00000370355 | GABRG2 | chr5 | 161582396 | - | SCD | chr10 | 102120947 | - |
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FusionProtFeatures for GABRG2_SCD |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GABRG2 | SCD |