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Fusion gene ID: 14220 |
FusionGeneSummary for GABBR2_UBE2H |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GABBR2_UBE2H | Fusion gene ID: 14220 | Hgene | Tgene | Gene symbol | GABBR2 | UBE2H | Gene ID | 9568 | 7328 |
| Gene name | gamma-aminobutyric acid type B receptor subunit 2 | ubiquitin conjugating enzyme E2 H | |
| Synonyms | EIEE59|GABABR2|GPR51|GPRC3B|HG20|HRIHFB2099|NDPLHS | E2-20K|GID3|UBC8|UBCH|UBCH2 | |
| Cytomap | 9q22.33 | 7q32.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | gamma-aminobutyric acid type B receptor subunit 2G-protein coupled receptor 51GABA-B receptor 2GABA-B receptor, R2 subunitGABA-B-R2GABA-BR2gamma-aminobutyric acid (GABA) B receptor, 2gamma-aminobutyric acid B receptor 2gb2 | ubiquitin-conjugating enzyme E2 H(E3-independent) E2 ubiquitin-conjugating enzyme HE2 ubiquitin-conjugating enzyme HGID complex subunit 3, UBC8 homologubiquitin carrier protein Hubiquitin conjugating enzyme E2Hubiquitin-conjugating enzyme E2-20Kubi | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | O75899 | P62256 | |
| Ensembl transtripts involved in fusion gene | ENST00000259455, ENST00000477471, | ENST00000355621, ENST00000473814, | |
| Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 7 X 8 X 4=224 |
| # samples | 4 | 10 | |
| ** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(10/224*10)=-1.16349873228288 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: GABBR2 [Title/Abstract] AND UBE2H [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | GABBR2 | GO:0007214 | gamma-aminobutyric acid signaling pathway | 9872316 |
| Tgene | UBE2H | GO:0070936 | protein K48-linked ubiquitination | 20061386 |
| Tgene | UBE2H | GO:0070979 | protein K11-linked ubiquitination | 20061386 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BE766562 | GABBR2 | chr9 | 101052890 | - | UBE2H | chr7 | 129569478 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000259455 | ENST00000355621 | GABBR2 | chr9 | 101052890 | - | UBE2H | chr7 | 129569478 | + |
| intron-intron | ENST00000259455 | ENST00000473814 | GABBR2 | chr9 | 101052890 | - | UBE2H | chr7 | 129569478 | + |
| intron-intron | ENST00000477471 | ENST00000355621 | GABBR2 | chr9 | 101052890 | - | UBE2H | chr7 | 129569478 | + |
| intron-intron | ENST00000477471 | ENST00000473814 | GABBR2 | chr9 | 101052890 | - | UBE2H | chr7 | 129569478 | + |
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FusionProtFeatures for GABBR2_UBE2H |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GABBR2 | UBE2H |