	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 14210

FusionGeneSummary for GABARAPL2_TP63

Fusion gene summary

Fusion gene information	Fusion gene name: GABARAPL2_TP63
	Fusion gene ID: 14210
		Hgene	Tgene
	Gene symbol	GABARAPL2	TP63
	Gene ID	11345	8626
	Gene name	GABA type A receptor associated protein like 2	tumor protein p63
	Synonyms	ATG8\|ATG8C\|GATE-16\|GATE16\|GEF-2\|GEF2	AIS\|B(p51A)\|B(p51B)\|EEC3\|KET\|LMS\|NBP\|OFC8\|RHS\|SHFM4\|TP53CP\|TP53L\|TP73L\|p40\|p51\|p53CP\|p63\|p73H\|p73L
	Cytomap	16q23.1	3q28
	Type of gene	protein-coding	protein-coding
	Description	gamma-aminobutyric acid receptor-associated protein-like 2GABA(A) receptor-associated protein-like 2MAP1 light chain 3 related proteinganglioside expression factor 2general protein transport factor p16golgi-associated ATPase enhancer of 16 kDa	tumor protein 63amplified in squamous cell carcinomachronic ulcerative stomatitis proteinkeratinocyte transcription factor KETtransformation-related protein 63tumor protein p53-competing protein
	Modification date	20180523	20180521
	UniProtAcc	P60520	Q9H3D4
	Ensembl transtripts involved in fusion gene	ENST00000037243, ENST00000565057, ENST00000563744, ENST00000568455, ENST00000565985,	ENST00000264731, ENST00000382063, ENST00000418709, ENST00000320472, ENST00000392460, ENST00000440651, ENST00000354600, ENST00000437221, ENST00000392463, ENST00000392461, ENST00000456148, ENST00000449992,
Fusion gene scores	* DoF score	1 X 1 X 1=1	6 X 5 X 4=120
	# samples	1	6
	** MAII score	log2(1/1*10)=3.32192809488736	log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: GABARAPL2 [Title/Abstract] AND TP63 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	TP63	GO:0045747	positive regulation of Notch signaling pathway	11641404
Tgene	TP63	GO:0045892	negative regulation of transcription, DNA-templated	12446784
Tgene	TP63	GO:0045893	positive regulation of transcription, DNA-templated	12446784\|16343436
Tgene	TP63	GO:0045944	positive regulation of transcription by RNA polymerase II	22521434
Tgene	TP63	GO:2000271	positive regulation of fibroblast apoptotic process	9774969

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BE843564	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3UTR	ENST00000037243	ENST00000264731	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
3UTR-3UTR	ENST00000037243	ENST00000382063	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
3UTR-intron	ENST00000037243	ENST00000418709	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
3UTR-intron	ENST00000037243	ENST00000320472	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
3UTR-intron	ENST00000037243	ENST00000392460	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
3UTR-intron	ENST00000037243	ENST00000440651	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
3UTR-3UTR	ENST00000037243	ENST00000354600	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
3UTR-intron	ENST00000037243	ENST00000437221	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
3UTR-intron	ENST00000037243	ENST00000392463	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
3UTR-intron	ENST00000037243	ENST00000392461	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
3UTR-intron	ENST00000037243	ENST00000456148	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
3UTR-intron	ENST00000037243	ENST00000449992	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
intron-3UTR	ENST00000565057	ENST00000264731	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
intron-3UTR	ENST00000565057	ENST00000382063	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
intron-intron	ENST00000565057	ENST00000418709	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
intron-intron	ENST00000565057	ENST00000320472	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
intron-intron	ENST00000565057	ENST00000392460	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
intron-intron	ENST00000565057	ENST00000440651	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
intron-3UTR	ENST00000565057	ENST00000354600	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
intron-intron	ENST00000565057	ENST00000437221	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
intron-intron	ENST00000565057	ENST00000392463	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
intron-intron	ENST00000565057	ENST00000392461	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
intron-intron	ENST00000565057	ENST00000456148	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
intron-intron	ENST00000565057	ENST00000449992	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
3UTR-3UTR	ENST00000563744	ENST00000264731	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
3UTR-3UTR	ENST00000563744	ENST00000382063	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
3UTR-intron	ENST00000563744	ENST00000418709	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
3UTR-intron	ENST00000563744	ENST00000320472	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
3UTR-intron	ENST00000563744	ENST00000392460	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
3UTR-intron	ENST00000563744	ENST00000440651	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
3UTR-3UTR	ENST00000563744	ENST00000354600	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
3UTR-intron	ENST00000563744	ENST00000437221	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
3UTR-intron	ENST00000563744	ENST00000392463	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
3UTR-intron	ENST00000563744	ENST00000392461	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
3UTR-intron	ENST00000563744	ENST00000456148	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
3UTR-intron	ENST00000563744	ENST00000449992	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
intron-3UTR	ENST00000568455	ENST00000264731	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
intron-3UTR	ENST00000568455	ENST00000382063	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
intron-intron	ENST00000568455	ENST00000418709	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
intron-intron	ENST00000568455	ENST00000320472	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
intron-intron	ENST00000568455	ENST00000392460	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
intron-intron	ENST00000568455	ENST00000440651	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
intron-3UTR	ENST00000568455	ENST00000354600	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
intron-intron	ENST00000568455	ENST00000437221	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
intron-intron	ENST00000568455	ENST00000392463	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
intron-intron	ENST00000568455	ENST00000392461	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
intron-intron	ENST00000568455	ENST00000456148	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
intron-intron	ENST00000568455	ENST00000449992	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
3UTR-3UTR	ENST00000565985	ENST00000264731	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
3UTR-3UTR	ENST00000565985	ENST00000382063	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
3UTR-intron	ENST00000565985	ENST00000418709	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
3UTR-intron	ENST00000565985	ENST00000320472	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
3UTR-intron	ENST00000565985	ENST00000392460	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
3UTR-intron	ENST00000565985	ENST00000440651	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
3UTR-3UTR	ENST00000565985	ENST00000354600	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
3UTR-intron	ENST00000565985	ENST00000437221	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
3UTR-intron	ENST00000565985	ENST00000392463	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
3UTR-intron	ENST00000565985	ENST00000392461	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
3UTR-intron	ENST00000565985	ENST00000456148	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+
3UTR-intron	ENST00000565985	ENST00000449992	GABARAPL2	chr16	75611449	+	TP63	chr3	189614740	+

Top

FusionProtFeatures for GABARAPL2_TP63

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GABARAPL2 P60520	TP63 Q9H3D4

Home

Download

Statistics

Examples

Help

Contact

Fusion gene ID: 14210

FusionGeneSummary for GABARAPL2_TP63

FusionProtFeatures for GABARAPL2_TP63