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Fusion gene ID: 14162 |
FusionGeneSummary for FZD3_ZNF141 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FZD3_ZNF141 | Fusion gene ID: 14162 | Hgene | Tgene | Gene symbol | FZD3 | ZNF141 | Gene ID | 7976 | 7700 |
| Gene name | frizzled class receptor 3 | zinc finger protein 141 | |
| Synonyms | Fz-3 | D4S90|pHZ-44 | |
| Cytomap | 8p21.1 | 4p16.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | frizzled-3frizzled 3, seven transmembrane spanning receptorfrizzled family receptor 3frizzled homolog 3 | zinc finger protein 141zinc finger protein 141 (clone pHZ-44) | |
| Modification date | 20180523 | 20180403 | |
| UniProtAcc | Q9NPG1 | Q15928 | |
| Ensembl transtripts involved in fusion gene | ENST00000537916, ENST00000240093, ENST00000517911, | ENST00000512994, ENST00000505939, ENST00000240499, ENST00000579770, | |
| Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 1 X 1 X 1=1 |
| # samples | 2 | 1 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: FZD3 [Title/Abstract] AND ZNF141 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | FZD3 | GO:0060070 | canonical Wnt signaling pathway | 20802536 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BU531878 | FZD3 | chr8 | 28385342 | + | ZNF141 | chr4 | 317886 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000537916 | ENST00000512994 | FZD3 | chr8 | 28385342 | + | ZNF141 | chr4 | 317886 | + |
| 5CDS-intron | ENST00000537916 | ENST00000505939 | FZD3 | chr8 | 28385342 | + | ZNF141 | chr4 | 317886 | + |
| 5CDS-intron | ENST00000537916 | ENST00000240499 | FZD3 | chr8 | 28385342 | + | ZNF141 | chr4 | 317886 | + |
| 5CDS-intron | ENST00000537916 | ENST00000579770 | FZD3 | chr8 | 28385342 | + | ZNF141 | chr4 | 317886 | + |
| 5CDS-intron | ENST00000240093 | ENST00000512994 | FZD3 | chr8 | 28385342 | + | ZNF141 | chr4 | 317886 | + |
| 5CDS-intron | ENST00000240093 | ENST00000505939 | FZD3 | chr8 | 28385342 | + | ZNF141 | chr4 | 317886 | + |
| 5CDS-intron | ENST00000240093 | ENST00000240499 | FZD3 | chr8 | 28385342 | + | ZNF141 | chr4 | 317886 | + |
| 5CDS-intron | ENST00000240093 | ENST00000579770 | FZD3 | chr8 | 28385342 | + | ZNF141 | chr4 | 317886 | + |
| intron-intron | ENST00000517911 | ENST00000512994 | FZD3 | chr8 | 28385342 | + | ZNF141 | chr4 | 317886 | + |
| intron-intron | ENST00000517911 | ENST00000505939 | FZD3 | chr8 | 28385342 | + | ZNF141 | chr4 | 317886 | + |
| intron-intron | ENST00000517911 | ENST00000240499 | FZD3 | chr8 | 28385342 | + | ZNF141 | chr4 | 317886 | + |
| intron-intron | ENST00000517911 | ENST00000579770 | FZD3 | chr8 | 28385342 | + | ZNF141 | chr4 | 317886 | + |
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FusionProtFeatures for FZD3_ZNF141 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FZD3 | ZNF141 |