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Fusion gene ID: 1415

FusionGeneSummary for AKT3_ANK3

Fusion gene summary

Fusion gene information	Fusion gene name: AKT3_ANK3
	Fusion gene ID: 1415
		Hgene	Tgene
	Gene symbol	AKT3	ANK3
	Gene ID	10000	288
	Gene name	AKT serine/threonine kinase 3	ankyrin 3
	Synonyms	MPPH\|MPPH2\|PKB-GAMMA\|PKBG\|PRKBG\|RAC-PK-gamma\|RAC-gamma\|STK-2	ANKYRIN-G\|MRT37
	Cytomap	1q43-q44	10q21.2
	Type of gene	protein-coding	protein-coding
	Description	RAC-gamma serine/threonine-protein kinasePKB gammaRAC-gamma serine/threonine protein kinasev-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)	ankyrin-3ankyrin 3, node of Ranvier (ankyrin G)
	Modification date	20180523	20180523
	UniProtAcc	Q9Y243	Q12955
	Ensembl transtripts involved in fusion gene	ENST00000336199, ENST00000366540, ENST00000366539, ENST00000263826, ENST00000492957,	ENST00000280772, ENST00000373827, ENST00000355288, ENST00000503366, ENST00000510382, ENST00000460468,
Fusion gene scores	* DoF score	8 X 5 X 5=200	12 X 16 X 9=1728
	# samples	9	18
	** MAII score	log2(9/200*10)=-1.15200309344505 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(18/1728*10)=-3.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: AKT3 [Title/Abstract] AND ANK3 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	AKT3	GO:0043536	positive regulation of blood vessel endothelial cell migration	28254819
Hgene	AKT3	GO:1905564	positive regulation of vascular endothelial cell proliferation	28254819

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BE708406	AKT3	chr1	243762537	-	ANK3	chr10	61789448	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3UTR	ENST00000336199	ENST00000280772	AKT3	chr1	243762537	-	ANK3	chr10	61789448	+
intron-3UTR	ENST00000336199	ENST00000373827	AKT3	chr1	243762537	-	ANK3	chr10	61789448	+
intron-intron	ENST00000336199	ENST00000355288	AKT3	chr1	243762537	-	ANK3	chr10	61789448	+
intron-intron	ENST00000336199	ENST00000503366	AKT3	chr1	243762537	-	ANK3	chr10	61789448	+
intron-intron	ENST00000336199	ENST00000510382	AKT3	chr1	243762537	-	ANK3	chr10	61789448	+
intron-intron	ENST00000336199	ENST00000460468	AKT3	chr1	243762537	-	ANK3	chr10	61789448	+
intron-3UTR	ENST00000366540	ENST00000280772	AKT3	chr1	243762537	-	ANK3	chr10	61789448	+
intron-3UTR	ENST00000366540	ENST00000373827	AKT3	chr1	243762537	-	ANK3	chr10	61789448	+
intron-intron	ENST00000366540	ENST00000355288	AKT3	chr1	243762537	-	ANK3	chr10	61789448	+
intron-intron	ENST00000366540	ENST00000503366	AKT3	chr1	243762537	-	ANK3	chr10	61789448	+
intron-intron	ENST00000366540	ENST00000510382	AKT3	chr1	243762537	-	ANK3	chr10	61789448	+
intron-intron	ENST00000366540	ENST00000460468	AKT3	chr1	243762537	-	ANK3	chr10	61789448	+
intron-3UTR	ENST00000366539	ENST00000280772	AKT3	chr1	243762537	-	ANK3	chr10	61789448	+
intron-3UTR	ENST00000366539	ENST00000373827	AKT3	chr1	243762537	-	ANK3	chr10	61789448	+
intron-intron	ENST00000366539	ENST00000355288	AKT3	chr1	243762537	-	ANK3	chr10	61789448	+
intron-intron	ENST00000366539	ENST00000503366	AKT3	chr1	243762537	-	ANK3	chr10	61789448	+
intron-intron	ENST00000366539	ENST00000510382	AKT3	chr1	243762537	-	ANK3	chr10	61789448	+
intron-intron	ENST00000366539	ENST00000460468	AKT3	chr1	243762537	-	ANK3	chr10	61789448	+
intron-3UTR	ENST00000263826	ENST00000280772	AKT3	chr1	243762537	-	ANK3	chr10	61789448	+
intron-3UTR	ENST00000263826	ENST00000373827	AKT3	chr1	243762537	-	ANK3	chr10	61789448	+
intron-intron	ENST00000263826	ENST00000355288	AKT3	chr1	243762537	-	ANK3	chr10	61789448	+
intron-intron	ENST00000263826	ENST00000503366	AKT3	chr1	243762537	-	ANK3	chr10	61789448	+
intron-intron	ENST00000263826	ENST00000510382	AKT3	chr1	243762537	-	ANK3	chr10	61789448	+
intron-intron	ENST00000263826	ENST00000460468	AKT3	chr1	243762537	-	ANK3	chr10	61789448	+
intron-3UTR	ENST00000492957	ENST00000280772	AKT3	chr1	243762537	-	ANK3	chr10	61789448	+
intron-3UTR	ENST00000492957	ENST00000373827	AKT3	chr1	243762537	-	ANK3	chr10	61789448	+
intron-intron	ENST00000492957	ENST00000355288	AKT3	chr1	243762537	-	ANK3	chr10	61789448	+
intron-intron	ENST00000492957	ENST00000503366	AKT3	chr1	243762537	-	ANK3	chr10	61789448	+
intron-intron	ENST00000492957	ENST00000510382	AKT3	chr1	243762537	-	ANK3	chr10	61789448	+
intron-intron	ENST00000492957	ENST00000460468	AKT3	chr1	243762537	-	ANK3	chr10	61789448	+

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FusionProtFeatures for AKT3_ANK3

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
AKT3 Q9Y243	ANK3 Q12955

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Fusion gene ID: 1415

FusionGeneSummary for AKT3_ANK3

FusionProtFeatures for AKT3_ANK3