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Fusion gene ID: 14103 |
FusionGeneSummary for FUT5_ZFP36 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FUT5_ZFP36 | Fusion gene ID: 14103 | Hgene | Tgene | Gene symbol | FUT5 | ZFP36 | Gene ID | 2527 | 7538 |
| Gene name | fucosyltransferase 5 | ZFP36 ring finger protein | |
| Synonyms | FUC-TV | G0S24|GOS24|NUP475|RNF162A|TIS11|TTP|zfp-36 | |
| Cytomap | 19p13.3 | 19q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | alpha-(1,3)-fucosyltransferase 5alpha (1,3) fucosyltransferasefucT-Vfucosyltransferase Vgalactoside 3-L-fucosyltransferase | mRNA decay activator protein ZFP36G0/G1 switch regulatory protein 24growth factor-inducible nuclear protein NUP475tristetraprolintristetraprolinezinc finger protein 36 homologzinc finger protein 36, C3H type, homologzinc finger protein, C3H type, 3 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q11128 | P26651 | |
| Ensembl transtripts involved in fusion gene | ENST00000252675, ENST00000588525, | ENST00000597629, ENST00000248673, ENST00000594045, | |
| Fusion gene scores | * DoF score | 2 X 3 X 1=6 | 6 X 6 X 1=36 |
| # samples | 3 | 6 | |
| ** MAII score | log2(3/6*10)=2.32192809488736 | log2(6/36*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: FUT5 [Title/Abstract] AND ZFP36 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | FUT5 | GO:0006672 | ceramide metabolic process | 7721776|17604274 |
| Tgene | ZFP36 | GO:0000288 | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | 23644599 |
| Tgene | ZFP36 | GO:0006402 | mRNA catabolic process | 10330172|10751406|11782475|20221403 |
| Tgene | ZFP36 | GO:0009611 | response to wounding | 27182009 |
| Tgene | ZFP36 | GO:0031086 | nuclear-transcribed mRNA catabolic process, deadenylation-independent decay | 11279239 |
| Tgene | ZFP36 | GO:0032680 | regulation of tumor necrosis factor production | 15014438 |
| Tgene | ZFP36 | GO:0042594 | response to starvation | 15014438 |
| Tgene | ZFP36 | GO:0043488 | regulation of mRNA stability | 9703499|11719186|15687258|20702587 |
| Tgene | ZFP36 | GO:0044344 | cellular response to fibroblast growth factor stimulus | 20166898 |
| Tgene | ZFP36 | GO:0045647 | negative regulation of erythrocyte differentiation | 20702587 |
| Tgene | ZFP36 | GO:0060213 | positive regulation of nuclear-transcribed mRNA poly(A) tail shortening | 10330172 |
| Tgene | ZFP36 | GO:0061158 | 3'-UTR-mediated mRNA destabilization | 9703499|11719186|15687258|20221403|27193233 |
| Tgene | ZFP36 | GO:0070935 | 3'-UTR-mediated mRNA stabilization | 15014438 |
| Tgene | ZFP36 | GO:0071222 | cellular response to lipopolysaccharide | 14766228 |
| Tgene | ZFP36 | GO:0071356 | cellular response to tumor necrosis factor | 20166898 |
| Tgene | ZFP36 | GO:0071364 | cellular response to epidermal growth factor stimulus | 20166898 |
| Tgene | ZFP36 | GO:0071385 | cellular response to glucocorticoid stimulus | 20166898 |
| Tgene | ZFP36 | GO:0097011 | cellular response to granulocyte macrophage colony-stimulating factor stimulus | 20166898 |
| Tgene | ZFP36 | GO:1900153 | positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | 12748283 |
| Tgene | ZFP36 | GO:1901835 | positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA | 16364915 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AI927524 | FUT5 | chr19 | 5894806 | + | ZFP36 | chr19 | 39899042 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000252675 | ENST00000597629 | FUT5 | chr19 | 5894806 | + | ZFP36 | chr19 | 39899042 | - |
| intron-3CDS | ENST00000252675 | ENST00000248673 | FUT5 | chr19 | 5894806 | + | ZFP36 | chr19 | 39899042 | - |
| intron-intron | ENST00000252675 | ENST00000594045 | FUT5 | chr19 | 5894806 | + | ZFP36 | chr19 | 39899042 | - |
| intron-3CDS | ENST00000588525 | ENST00000597629 | FUT5 | chr19 | 5894806 | + | ZFP36 | chr19 | 39899042 | - |
| intron-3CDS | ENST00000588525 | ENST00000248673 | FUT5 | chr19 | 5894806 | + | ZFP36 | chr19 | 39899042 | - |
| intron-intron | ENST00000588525 | ENST00000594045 | FUT5 | chr19 | 5894806 | + | ZFP36 | chr19 | 39899042 | - |
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FusionProtFeatures for FUT5_ZFP36 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FUT5 | ZFP36 |