|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 14093 |
FusionGeneSummary for FUS_SRR |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FUS_SRR | Fusion gene ID: 14093 | Hgene | Tgene | Gene symbol | FUS | SRR | Gene ID | 2521 | 63826 |
| Gene name | FUS RNA binding protein | serine racemase | |
| Synonyms | ALS6|ETM4|FUS1|HNRNPP2|POMP75|TLS | ILV1|ISO1 | |
| Cytomap | 16p11.2 | 17p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | RNA-binding protein FUS75 kDa DNA-pairing proteinFUS/ERG chimeric proteinFUS/ERG fusion proteinfus-like proteinfused in sarcomafusion gene in myxoid liposarcomaheterogeneous nuclear ribonucleoprotein P2oncogene FUSoncogene TLStranslocated in lip | serine racemaseD-serine ammonia-lyaseD-serine dehydrataseL-serine ammonia-lyaseL-serine dehydratase | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | P35637 | Q9GZT4 | |
| Ensembl transtripts involved in fusion gene | ENST00000254108, ENST00000380244, ENST00000568685, ENST00000474990, | ENST00000344595, ENST00000576848, | |
| Fusion gene scores | * DoF score | 21 X 23 X 7=3381 | 2 X 2 X 2=8 |
| # samples | 27 | 2 | |
| ** MAII score | log2(27/3381*10)=-3.64641870384255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: FUS [Title/Abstract] AND SRR [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SRR | GO:0006563 | L-serine metabolic process | 11054547|15193426|20106978 |
| Tgene | SRR | GO:0042866 | pyruvate biosynthetic process | 18812225 |
| Tgene | SRR | GO:0070178 | D-serine metabolic process | 20106978 |
| Tgene | SRR | GO:0070179 | D-serine biosynthetic process | 11054547|15193426 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AA614279 | FUS | chr16 | 31202314 | - | SRR | chr17 | 2208483 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000254108 | ENST00000344595 | FUS | chr16 | 31202314 | - | SRR | chr17 | 2208483 | - |
| 5CDS-intron | ENST00000254108 | ENST00000576848 | FUS | chr16 | 31202314 | - | SRR | chr17 | 2208483 | - |
| 5CDS-intron | ENST00000380244 | ENST00000344595 | FUS | chr16 | 31202314 | - | SRR | chr17 | 2208483 | - |
| 5CDS-intron | ENST00000380244 | ENST00000576848 | FUS | chr16 | 31202314 | - | SRR | chr17 | 2208483 | - |
| 5CDS-intron | ENST00000568685 | ENST00000344595 | FUS | chr16 | 31202314 | - | SRR | chr17 | 2208483 | - |
| 5CDS-intron | ENST00000568685 | ENST00000576848 | FUS | chr16 | 31202314 | - | SRR | chr17 | 2208483 | - |
| 3UTR-intron | ENST00000474990 | ENST00000344595 | FUS | chr16 | 31202314 | - | SRR | chr17 | 2208483 | - |
| 3UTR-intron | ENST00000474990 | ENST00000576848 | FUS | chr16 | 31202314 | - | SRR | chr17 | 2208483 | - |
Top |
FusionProtFeatures for FUS_SRR |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FUS | SRR |