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Fusion gene ID: 14063

FusionGeneSummary for FUCA2_SSR2

Fusion gene summary

Fusion gene information	Fusion gene name: FUCA2_SSR2
	Fusion gene ID: 14063
		Hgene	Tgene
	Gene symbol	FUCA2	SSR2
	Gene ID	2519	6746
	Gene name	alpha-L-fucosidase 2	signal sequence receptor subunit 2
	Synonyms	dJ20N2.5	HSD25\|TLAP\|TRAP-BETA\|TRAPB
	Cytomap	6q24.2	1q22
	Type of gene	protein-coding	protein-coding
	Description	plasma alpha-L-fucosidaseI+/--L-fucosidase 2a-L-fucosidase 2alpha-L-fucoside fucohydrolase 2fucosidase, alpha-L- 2, plasmaplasma fucosidase	translocon-associated protein subunit betaSSR-betasignal sequence receptor subunit betasignal sequence receptor, beta (translocon-associated protein beta)translocon-associated protein beta
	Modification date	20180523	20180523
	UniProtAcc	Q9BTY2	P43308
	Ensembl transtripts involved in fusion gene	ENST00000002165, ENST00000438118, ENST00000367585,	ENST00000295702, ENST00000529008, ENST00000496742, ENST00000480567,
Fusion gene scores	* DoF score	1 X 1 X 1=1	6 X 7 X 4=168
	# samples	1	7
	** MAII score	log2(1/1*10)=3.32192809488736	log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: FUCA2 [Title/Abstract] AND SSR2 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	FUCA2	GO:0006004	fucose metabolic process	19666478
Hgene	FUCA2	GO:0016139	glycoside catabolic process	19666478

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BE837584	FUCA2	chr6	143816937	-	SSR2	chr1	155979271	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3UTR	ENST00000002165	ENST00000295702	FUCA2	chr6	143816937	-	SSR2	chr1	155979271	+
intron-3UTR	ENST00000002165	ENST00000529008	FUCA2	chr6	143816937	-	SSR2	chr1	155979271	+
intron-3UTR	ENST00000002165	ENST00000496742	FUCA2	chr6	143816937	-	SSR2	chr1	155979271	+
intron-3UTR	ENST00000002165	ENST00000480567	FUCA2	chr6	143816937	-	SSR2	chr1	155979271	+
intron-3UTR	ENST00000438118	ENST00000295702	FUCA2	chr6	143816937	-	SSR2	chr1	155979271	+
intron-3UTR	ENST00000438118	ENST00000529008	FUCA2	chr6	143816937	-	SSR2	chr1	155979271	+
intron-3UTR	ENST00000438118	ENST00000496742	FUCA2	chr6	143816937	-	SSR2	chr1	155979271	+
intron-3UTR	ENST00000438118	ENST00000480567	FUCA2	chr6	143816937	-	SSR2	chr1	155979271	+
intron-3UTR	ENST00000367585	ENST00000295702	FUCA2	chr6	143816937	-	SSR2	chr1	155979271	+
intron-3UTR	ENST00000367585	ENST00000529008	FUCA2	chr6	143816937	-	SSR2	chr1	155979271	+
intron-3UTR	ENST00000367585	ENST00000496742	FUCA2	chr6	143816937	-	SSR2	chr1	155979271	+
intron-3UTR	ENST00000367585	ENST00000480567	FUCA2	chr6	143816937	-	SSR2	chr1	155979271	+

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FusionProtFeatures for FUCA2_SSR2

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FUCA2 Q9BTY2	SSR2 P43308

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Fusion gene ID: 14063

FusionGeneSummary for FUCA2_SSR2

FusionProtFeatures for FUCA2_SSR2