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Fusion gene ID: 14047 |
FusionGeneSummary for FTO_RBL2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FTO_RBL2 | Fusion gene ID: 14047 | Hgene | Tgene | Gene symbol | FTO | RBL2 | Gene ID | 79068 | 5934 |
| Gene name | FTO, alpha-ketoglutarate dependent dioxygenase | RB transcriptional corepressor like 2 | |
| Synonyms | ALKBH9|BMIQ14|GDFD | P130|Rb2 | |
| Cytomap | 16q12.2 | 16q12.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | alpha-ketoglutarate-dependent dioxygenase FTOAlkB homolog 9fat mass and obesity associatedfat mass and obesity-associated protein | retinoblastoma-like protein 2130 kDa retinoblastoma-associated proteinPRB2RBR-2retinoblastoma-like 2retinoblastoma-related protein 2 | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | Q9C0B1 | Q08999 | |
| Ensembl transtripts involved in fusion gene | ENST00000471389, ENST00000394647, ENST00000431610, ENST00000460382, ENST00000463855, ENST00000472835, | ENST00000262133, ENST00000379935, ENST00000544545, | |
| Fusion gene scores | * DoF score | 5 X 2 X 5=50 | 4 X 3 X 3=36 |
| # samples | 5 | 4 | |
| ** MAII score | log2(5/50*10)=0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: FTO [Title/Abstract] AND RBL2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | FTO | GO:0006307 | DNA dealkylation involved in DNA repair | 18775698|20376003 |
| Hgene | FTO | GO:0035552 | oxidative single-stranded DNA demethylation | 18775698|20376003 |
| Hgene | FTO | GO:0035553 | oxidative single-stranded RNA demethylation | 18775698|22002720 |
| Hgene | FTO | GO:0042245 | RNA repair | 18775698 |
| Hgene | FTO | GO:0070989 | oxidative demethylation | 18775698 |
| Hgene | FTO | GO:0080111 | DNA demethylation | 18775698 |
| Tgene | RBL2 | GO:0043550 | regulation of lipid kinase activity | 16286473 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-95-8039-01A | FTO | chr16 | 53738141 | + | RBL2 | chr16 | 53472928 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000471389 | ENST00000262133 | FTO | chr16 | 53738141 | + | RBL2 | chr16 | 53472928 | + |
| 5CDS-intron | ENST00000471389 | ENST00000379935 | FTO | chr16 | 53738141 | + | RBL2 | chr16 | 53472928 | + |
| 5CDS-intron | ENST00000471389 | ENST00000544545 | FTO | chr16 | 53738141 | + | RBL2 | chr16 | 53472928 | + |
| 5UTR-3CDS | ENST00000394647 | ENST00000262133 | FTO | chr16 | 53738141 | + | RBL2 | chr16 | 53472928 | + |
| 5UTR-intron | ENST00000394647 | ENST00000379935 | FTO | chr16 | 53738141 | + | RBL2 | chr16 | 53472928 | + |
| 5UTR-intron | ENST00000394647 | ENST00000544545 | FTO | chr16 | 53738141 | + | RBL2 | chr16 | 53472928 | + |
| intron-3CDS | ENST00000431610 | ENST00000262133 | FTO | chr16 | 53738141 | + | RBL2 | chr16 | 53472928 | + |
| intron-intron | ENST00000431610 | ENST00000379935 | FTO | chr16 | 53738141 | + | RBL2 | chr16 | 53472928 | + |
| intron-intron | ENST00000431610 | ENST00000544545 | FTO | chr16 | 53738141 | + | RBL2 | chr16 | 53472928 | + |
| intron-3CDS | ENST00000460382 | ENST00000262133 | FTO | chr16 | 53738141 | + | RBL2 | chr16 | 53472928 | + |
| intron-intron | ENST00000460382 | ENST00000379935 | FTO | chr16 | 53738141 | + | RBL2 | chr16 | 53472928 | + |
| intron-intron | ENST00000460382 | ENST00000544545 | FTO | chr16 | 53738141 | + | RBL2 | chr16 | 53472928 | + |
| intron-3CDS | ENST00000463855 | ENST00000262133 | FTO | chr16 | 53738141 | + | RBL2 | chr16 | 53472928 | + |
| intron-intron | ENST00000463855 | ENST00000379935 | FTO | chr16 | 53738141 | + | RBL2 | chr16 | 53472928 | + |
| intron-intron | ENST00000463855 | ENST00000544545 | FTO | chr16 | 53738141 | + | RBL2 | chr16 | 53472928 | + |
| intron-3CDS | ENST00000472835 | ENST00000262133 | FTO | chr16 | 53738141 | + | RBL2 | chr16 | 53472928 | + |
| intron-intron | ENST00000472835 | ENST00000379935 | FTO | chr16 | 53738141 | + | RBL2 | chr16 | 53472928 | + |
| intron-intron | ENST00000472835 | ENST00000544545 | FTO | chr16 | 53738141 | + | RBL2 | chr16 | 53472928 | + |
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FusionProtFeatures for FTO_RBL2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FTO | RBL2 |