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Fusion gene ID: 14043 |
FusionGeneSummary for FTL_SUMO3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FTL_SUMO3 | Fusion gene ID: 14043 | Hgene | Tgene | Gene symbol | FTL | SUMO3 | Gene ID | 2512 | 6613 |
| Gene name | ferritin light chain | small ubiquitin-like modifier 2 | |
| Synonyms | LFTD|NBIA3 | HSMT3|SMT3B|SMT3H2|SUMO3|Smt3A | |
| Cytomap | 19q13.33 | 17q25.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ferritin light chainferritin L subunitferritin L-chainferritin light polypeptide-like 3ferritin, light polypeptide | small ubiquitin-related modifier 2SMT3 homolog 2SMT3 suppressor of mif two 3 homolog 2sentrin 2ubiquitin-like protein SMT3Aubiquitin-like protein SMT3B | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P02792 | P55854 | |
| Ensembl transtripts involved in fusion gene | ENST00000331825, | ENST00000397898, ENST00000332859, ENST00000479153, ENST00000411651, ENST00000397893, | |
| Fusion gene scores | * DoF score | 13 X 16 X 4=832 | 5 X 5 X 2=50 |
| # samples | 17 | 5 | |
| ** MAII score | log2(17/832*10)=-2.29104878200339 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/50*10)=0 | |
| Context | PubMed: FTL [Title/Abstract] AND SUMO3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SUMO3 | GO:0016925 | protein sumoylation | 17081986|17696781|21965678|24105744 |
| Tgene | SUMO3 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | 18408734 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CA448614 | FTL | chr19 | 49469908 | - | SUMO3 | chr21 | 46226193 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000331825 | ENST00000397898 | FTL | chr19 | 49469908 | - | SUMO3 | chr21 | 46226193 | + |
| 5CDS-3UTR | ENST00000331825 | ENST00000332859 | FTL | chr19 | 49469908 | - | SUMO3 | chr21 | 46226193 | + |
| 5CDS-5UTR | ENST00000331825 | ENST00000479153 | FTL | chr19 | 49469908 | - | SUMO3 | chr21 | 46226193 | + |
| 5CDS-intron | ENST00000331825 | ENST00000411651 | FTL | chr19 | 49469908 | - | SUMO3 | chr21 | 46226193 | + |
| 5CDS-intron | ENST00000331825 | ENST00000397893 | FTL | chr19 | 49469908 | - | SUMO3 | chr21 | 46226193 | + |
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FusionProtFeatures for FTL_SUMO3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FTL | SUMO3 |