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Fusion gene ID: 13976 |
FusionGeneSummary for FRS2_TBK1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FRS2_TBK1 | Fusion gene ID: 13976 | Hgene | Tgene | Gene symbol | FRS2 | TBK1 | Gene ID | 10818 | 29110 |
| Gene name | fibroblast growth factor receptor substrate 2 | TANK binding kinase 1 | |
| Synonyms | FRS1A|FRS2A|FRS2alpha|SNT|SNT-1|SNT1 | FTDALS4|IIAE8|NAK|T2K | |
| Cytomap | 12q15 | 12q14.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | fibroblast growth factor receptor substrate 2FGFR signalling adaptorFGFR substrate 2FGFR-signaling adaptor SNTsuc1-associated neurotrophic factor target 1 | serine/threonine-protein kinase TBK1NF-kB-activating kinaseNF-kappa-B-activating kinase | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q8WU20 | Q9UHD2 | |
| Ensembl transtripts involved in fusion gene | ENST00000299293, ENST00000549921, ENST00000550389, ENST00000397997, | ENST00000331710, | |
| Fusion gene scores | * DoF score | 56 X 9 X 12=6048 | 4 X 4 X 5=80 |
| # samples | 47 | 6 | |
| ** MAII score | log2(47/6048*10)=-3.68572547765607 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/80*10)=-0.415037499278844 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FRS2 [Title/Abstract] AND TBK1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | TBK1 | GO:0006468 | protein phosphorylation | 27103069 |
| Tgene | TBK1 | GO:0016239 | positive regulation of macroautophagy | 27103069 |
| Tgene | TBK1 | GO:0018105 | peptidyl-serine phosphorylation | 25803835|27103069 |
| Tgene | TBK1 | GO:0018107 | peptidyl-threonine phosphorylation | 27103069 |
| Tgene | TBK1 | GO:0032727 | positive regulation of interferon-alpha production | 16127453 |
| Tgene | TBK1 | GO:0032728 | positive regulation of interferon-beta production | 16127453 |
| Tgene | TBK1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 16127453 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-DX-A7EI-01A | FRS2 | chr12 | 69864310 | + | TBK1 | chr12 | 64860681 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000299293 | ENST00000331710 | FRS2 | chr12 | 69864310 | + | TBK1 | chr12 | 64860681 | + |
| 5UTR-3CDS | ENST00000549921 | ENST00000331710 | FRS2 | chr12 | 69864310 | + | TBK1 | chr12 | 64860681 | + |
| 5UTR-3CDS | ENST00000550389 | ENST00000331710 | FRS2 | chr12 | 69864310 | + | TBK1 | chr12 | 64860681 | + |
| intron-3CDS | ENST00000397997 | ENST00000331710 | FRS2 | chr12 | 69864310 | + | TBK1 | chr12 | 64860681 | + |
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FusionProtFeatures for FRS2_TBK1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FRS2 | TBK1 |