|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 13940 |
FusionGeneSummary for FRS2_DNM2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FRS2_DNM2 | Fusion gene ID: 13940 | Hgene | Tgene | Gene symbol | FRS2 | DNM2 | Gene ID | 10818 | 1785 |
| Gene name | fibroblast growth factor receptor substrate 2 | dynamin 2 | |
| Synonyms | FRS1A|FRS2A|FRS2alpha|SNT|SNT-1|SNT1 | CMT2M|CMTDI1|CMTDIB|DI-CMTB|DYN2|DYNII|LCCS5 | |
| Cytomap | 12q15 | 19p13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | fibroblast growth factor receptor substrate 2FGFR signalling adaptorFGFR substrate 2FGFR-signaling adaptor SNTsuc1-associated neurotrophic factor target 1 | dynamin-2dynamin II | |
| Modification date | 20180522 | 20180527 | |
| UniProtAcc | Q8WU20 | P50570 | |
| Ensembl transtripts involved in fusion gene | ENST00000299293, ENST00000549921, ENST00000550389, ENST00000397997, | ENST00000585892, ENST00000314646, ENST00000359692, ENST00000389253, ENST00000355667, ENST00000408974, ENST00000591819, | |
| Fusion gene scores | * DoF score | 56 X 9 X 12=6048 | 10 X 9 X 10=900 |
| # samples | 47 | 13 | |
| ** MAII score | log2(47/6048*10)=-3.68572547765607 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/900*10)=-2.79141337818858 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FRS2 [Title/Abstract] AND DNM2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | DNM2 | GO:1903526 | negative regulation of membrane tubulation | 18388313 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-FX-A3NK-01A | FRS2 | chr12 | 69864310 | + | DNM2 | chr19 | 10904396 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000299293 | ENST00000585892 | FRS2 | chr12 | 69864310 | + | DNM2 | chr19 | 10904396 | + |
| 5UTR-3CDS | ENST00000299293 | ENST00000314646 | FRS2 | chr12 | 69864310 | + | DNM2 | chr19 | 10904396 | + |
| 5UTR-3CDS | ENST00000299293 | ENST00000359692 | FRS2 | chr12 | 69864310 | + | DNM2 | chr19 | 10904396 | + |
| 5UTR-3CDS | ENST00000299293 | ENST00000389253 | FRS2 | chr12 | 69864310 | + | DNM2 | chr19 | 10904396 | + |
| 5UTR-3CDS | ENST00000299293 | ENST00000355667 | FRS2 | chr12 | 69864310 | + | DNM2 | chr19 | 10904396 | + |
| 5UTR-3CDS | ENST00000299293 | ENST00000408974 | FRS2 | chr12 | 69864310 | + | DNM2 | chr19 | 10904396 | + |
| 5UTR-intron | ENST00000299293 | ENST00000591819 | FRS2 | chr12 | 69864310 | + | DNM2 | chr19 | 10904396 | + |
| 5UTR-3CDS | ENST00000549921 | ENST00000585892 | FRS2 | chr12 | 69864310 | + | DNM2 | chr19 | 10904396 | + |
| 5UTR-3CDS | ENST00000549921 | ENST00000314646 | FRS2 | chr12 | 69864310 | + | DNM2 | chr19 | 10904396 | + |
| 5UTR-3CDS | ENST00000549921 | ENST00000359692 | FRS2 | chr12 | 69864310 | + | DNM2 | chr19 | 10904396 | + |
| 5UTR-3CDS | ENST00000549921 | ENST00000389253 | FRS2 | chr12 | 69864310 | + | DNM2 | chr19 | 10904396 | + |
| 5UTR-3CDS | ENST00000549921 | ENST00000355667 | FRS2 | chr12 | 69864310 | + | DNM2 | chr19 | 10904396 | + |
| 5UTR-3CDS | ENST00000549921 | ENST00000408974 | FRS2 | chr12 | 69864310 | + | DNM2 | chr19 | 10904396 | + |
| 5UTR-intron | ENST00000549921 | ENST00000591819 | FRS2 | chr12 | 69864310 | + | DNM2 | chr19 | 10904396 | + |
| 5UTR-3CDS | ENST00000550389 | ENST00000585892 | FRS2 | chr12 | 69864310 | + | DNM2 | chr19 | 10904396 | + |
| 5UTR-3CDS | ENST00000550389 | ENST00000314646 | FRS2 | chr12 | 69864310 | + | DNM2 | chr19 | 10904396 | + |
| 5UTR-3CDS | ENST00000550389 | ENST00000359692 | FRS2 | chr12 | 69864310 | + | DNM2 | chr19 | 10904396 | + |
| 5UTR-3CDS | ENST00000550389 | ENST00000389253 | FRS2 | chr12 | 69864310 | + | DNM2 | chr19 | 10904396 | + |
| 5UTR-3CDS | ENST00000550389 | ENST00000355667 | FRS2 | chr12 | 69864310 | + | DNM2 | chr19 | 10904396 | + |
| 5UTR-3CDS | ENST00000550389 | ENST00000408974 | FRS2 | chr12 | 69864310 | + | DNM2 | chr19 | 10904396 | + |
| 5UTR-intron | ENST00000550389 | ENST00000591819 | FRS2 | chr12 | 69864310 | + | DNM2 | chr19 | 10904396 | + |
| intron-3CDS | ENST00000397997 | ENST00000585892 | FRS2 | chr12 | 69864310 | + | DNM2 | chr19 | 10904396 | + |
| intron-3CDS | ENST00000397997 | ENST00000314646 | FRS2 | chr12 | 69864310 | + | DNM2 | chr19 | 10904396 | + |
| intron-3CDS | ENST00000397997 | ENST00000359692 | FRS2 | chr12 | 69864310 | + | DNM2 | chr19 | 10904396 | + |
| intron-3CDS | ENST00000397997 | ENST00000389253 | FRS2 | chr12 | 69864310 | + | DNM2 | chr19 | 10904396 | + |
| intron-3CDS | ENST00000397997 | ENST00000355667 | FRS2 | chr12 | 69864310 | + | DNM2 | chr19 | 10904396 | + |
| intron-3CDS | ENST00000397997 | ENST00000408974 | FRS2 | chr12 | 69864310 | + | DNM2 | chr19 | 10904396 | + |
| intron-intron | ENST00000397997 | ENST00000591819 | FRS2 | chr12 | 69864310 | + | DNM2 | chr19 | 10904396 | + |
Top |
FusionProtFeatures for FRS2_DNM2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FRS2 | DNM2 |