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Fusion gene ID: 13927

FusionGeneSummary for FRS2_AHCYL2

Fusion gene summary

Fusion gene information	Fusion gene name: FRS2_AHCYL2
	Fusion gene ID: 13927
		Hgene	Tgene
	Gene symbol	FRS2	AHCYL2
	Gene ID	10818	23382
	Gene name	fibroblast growth factor receptor substrate 2	adenosylhomocysteinase like 2
	Synonyms	FRS1A\|FRS2A\|FRS2alpha\|SNT\|SNT-1\|SNT1	ADOHCYASE3\|IRBIT2
	Cytomap	12q15	7q32.1
	Type of gene	protein-coding	protein-coding
	Description	fibroblast growth factor receptor substrate 2FGFR signalling adaptorFGFR substrate 2FGFR-signaling adaptor SNTsuc1-associated neurotrophic factor target 1	adenosylhomocysteinase 3IP(3)Rs binding protein released with IP(3) 2S-adenosyl-L-homocysteine hydrolase 3S-adenosylhomocysteine hydrolase-like 2long-IRBITputative adenosylhomocysteinase 3
	Modification date	20180522	20180523
	UniProtAcc	Q8WU20	Q96HN2
	Ensembl transtripts involved in fusion gene	ENST00000299293, ENST00000549921, ENST00000550389, ENST00000397997,	ENST00000325006, ENST00000446544, ENST00000531335, ENST00000474594, ENST00000446212, ENST00000490911, ENST00000472554,
Fusion gene scores	* DoF score	56 X 9 X 12=6048	7 X 5 X 5=175
	# samples	47	7
	** MAII score	log2(47/6048*10)=-3.68572547765607 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/175*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: FRS2 [Title/Abstract] AND AHCYL2 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	SARC	TCGA-DX-A6BH-01A	FRS2	chr12	69967865	+	AHCYL2	chr7	129019482	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000299293	ENST00000325006	FRS2	chr12	69967865	+	AHCYL2	chr7	129019482	+
In-frame	ENST00000299293	ENST00000446544	FRS2	chr12	69967865	+	AHCYL2	chr7	129019482	+
In-frame	ENST00000299293	ENST00000531335	FRS2	chr12	69967865	+	AHCYL2	chr7	129019482	+
In-frame	ENST00000299293	ENST00000474594	FRS2	chr12	69967865	+	AHCYL2	chr7	129019482	+
In-frame	ENST00000299293	ENST00000446212	FRS2	chr12	69967865	+	AHCYL2	chr7	129019482	+
In-frame	ENST00000299293	ENST00000490911	FRS2	chr12	69967865	+	AHCYL2	chr7	129019482	+
5CDS-intron	ENST00000299293	ENST00000472554	FRS2	chr12	69967865	+	AHCYL2	chr7	129019482	+
In-frame	ENST00000549921	ENST00000325006	FRS2	chr12	69967865	+	AHCYL2	chr7	129019482	+
In-frame	ENST00000549921	ENST00000446544	FRS2	chr12	69967865	+	AHCYL2	chr7	129019482	+
In-frame	ENST00000549921	ENST00000531335	FRS2	chr12	69967865	+	AHCYL2	chr7	129019482	+
In-frame	ENST00000549921	ENST00000474594	FRS2	chr12	69967865	+	AHCYL2	chr7	129019482	+
In-frame	ENST00000549921	ENST00000446212	FRS2	chr12	69967865	+	AHCYL2	chr7	129019482	+
In-frame	ENST00000549921	ENST00000490911	FRS2	chr12	69967865	+	AHCYL2	chr7	129019482	+
5CDS-intron	ENST00000549921	ENST00000472554	FRS2	chr12	69967865	+	AHCYL2	chr7	129019482	+
In-frame	ENST00000550389	ENST00000325006	FRS2	chr12	69967865	+	AHCYL2	chr7	129019482	+
In-frame	ENST00000550389	ENST00000446544	FRS2	chr12	69967865	+	AHCYL2	chr7	129019482	+
In-frame	ENST00000550389	ENST00000531335	FRS2	chr12	69967865	+	AHCYL2	chr7	129019482	+
In-frame	ENST00000550389	ENST00000474594	FRS2	chr12	69967865	+	AHCYL2	chr7	129019482	+
In-frame	ENST00000550389	ENST00000446212	FRS2	chr12	69967865	+	AHCYL2	chr7	129019482	+
In-frame	ENST00000550389	ENST00000490911	FRS2	chr12	69967865	+	AHCYL2	chr7	129019482	+
5CDS-intron	ENST00000550389	ENST00000472554	FRS2	chr12	69967865	+	AHCYL2	chr7	129019482	+
In-frame	ENST00000397997	ENST00000325006	FRS2	chr12	69967865	+	AHCYL2	chr7	129019482	+
In-frame	ENST00000397997	ENST00000446544	FRS2	chr12	69967865	+	AHCYL2	chr7	129019482	+
In-frame	ENST00000397997	ENST00000531335	FRS2	chr12	69967865	+	AHCYL2	chr7	129019482	+
In-frame	ENST00000397997	ENST00000474594	FRS2	chr12	69967865	+	AHCYL2	chr7	129019482	+
In-frame	ENST00000397997	ENST00000446212	FRS2	chr12	69967865	+	AHCYL2	chr7	129019482	+
In-frame	ENST00000397997	ENST00000490911	FRS2	chr12	69967865	+	AHCYL2	chr7	129019482	+
5CDS-intron	ENST00000397997	ENST00000472554	FRS2	chr12	69967865	+	AHCYL2	chr7	129019482	+

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FusionProtFeatures for FRS2_AHCYL2

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FRS2 Q8WU20	AHCYL2 Q96HN2

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Fusion gene ID: 13927

FusionGeneSummary for FRS2_AHCYL2

FusionProtFeatures for FRS2_AHCYL2