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Fusion gene ID: 13905 |
FusionGeneSummary for FRMD5_MFAP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FRMD5_MFAP1 | Fusion gene ID: 13905 | Hgene | Tgene | Gene symbol | FRMD5 | MFAP1 | Gene ID | 84978 | 4236 |
| Gene name | FERM domain containing 5 | microfibril associated protein 1 | |
| Synonyms | - | AMP | |
| Cytomap | 15q15.3 | 15q15.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | FERM domain-containing protein 5 | microfibrillar-associated protein 1microfibrillar associated protein 1 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q7Z6J6 | P55081 | |
| Ensembl transtripts involved in fusion gene | ENST00000417257, ENST00000402883, ENST00000484674, | ENST00000267812, | |
| Fusion gene scores | * DoF score | 4 X 3 X 3=36 | 5 X 6 X 3=90 |
| # samples | 4 | 6 | |
| ** MAII score | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FRMD5 [Title/Abstract] AND MFAP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUAD | TCGA-38-4630-01A | FRMD5 | chr15 | 44487151 | - | MFAP1 | chr15 | 44109646 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000417257 | ENST00000267812 | FRMD5 | chr15 | 44487151 | - | MFAP1 | chr15 | 44109646 | - |
| Frame-shift | ENST00000402883 | ENST00000267812 | FRMD5 | chr15 | 44487151 | - | MFAP1 | chr15 | 44109646 | - |
| intron-3CDS | ENST00000484674 | ENST00000267812 | FRMD5 | chr15 | 44487151 | - | MFAP1 | chr15 | 44109646 | - |
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FusionProtFeatures for FRMD5_MFAP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FRMD5 | MFAP1 |