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Fusion gene ID: 1389

FusionGeneSummary for AKR1A1_AGO3

Fusion gene summary

Fusion gene information	Fusion gene name: AKR1A1_AGO3
	Fusion gene ID: 1389
		Hgene	Tgene
	Gene symbol	AKR1A1	AGO3
	Gene ID	10327	192669
	Gene name	aldo-keto reductase family 1 member A1	argonaute 3, RISC catalytic component
	Synonyms	ALDR1\|ALR\|ARM\|DD3\|HEL-S-6	EIF2C3
	Cytomap	1p34.1	1p34.3
	Type of gene	protein-coding	protein-coding
	Description	alcohol dehydrogenase [NADP(+)]HEL-S-165mPalcohol dehydrogenasealdehyde reductasedihydrodiol dehydrogenase 3epididymis secretory protein Li 6epididymis secretory sperm binding protein Li 165mP	protein argonaute-3argonaute RISC catalytic component 3eukaryotic translation initiation factor 2C, 3hAgo3
	Modification date	20180523	20180522
	UniProtAcc	P14550	Q9H9G7
	Ensembl transtripts involved in fusion gene	ENST00000372070, ENST00000351829, ENST00000471651, ENST00000473038,	ENST00000324350, ENST00000373191, ENST00000397828, ENST00000246314, ENST00000471099,
Fusion gene scores	* DoF score	4 X 4 X 2=32	8 X 5 X 8=320
	# samples	6	8
	** MAII score	log2(6/32*10)=0.906890595608518 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(8/320*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: AKR1A1 [Title/Abstract] AND AGO3 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	AGO3	GO:0006402	mRNA catabolic process	18771919
Tgene	AGO3	GO:0010501	RNA secondary structure unwinding	19966796
Tgene	AGO3	GO:0031054	pre-miRNA processing	19966796
Tgene	AGO3	GO:0035278	miRNA mediated inhibition of translation	18771919
Tgene	AGO3	GO:0035279	mRNA cleavage involved in gene silencing by miRNA	15260970
Tgene	AGO3	GO:0035280	miRNA loading onto RISC involved in gene silencing by miRNA	19966796
Tgene	AGO3	GO:0090625	mRNA cleavage involved in gene silencing by siRNA	15260970

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	HNSC	TCGA-F7-A61W-01A	AKR1A1	chr1	46027550	+	AGO3	chr1	36469942	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000372070	ENST00000324350	AKR1A1	chr1	46027550	+	AGO3	chr1	36469942	+
5CDS-intron	ENST00000372070	ENST00000373191	AKR1A1	chr1	46027550	+	AGO3	chr1	36469942	+
5CDS-intron	ENST00000372070	ENST00000397828	AKR1A1	chr1	46027550	+	AGO3	chr1	36469942	+
5CDS-5UTR	ENST00000372070	ENST00000246314	AKR1A1	chr1	46027550	+	AGO3	chr1	36469942	+
5CDS-intron	ENST00000372070	ENST00000471099	AKR1A1	chr1	46027550	+	AGO3	chr1	36469942	+
5CDS-intron	ENST00000351829	ENST00000324350	AKR1A1	chr1	46027550	+	AGO3	chr1	36469942	+
5CDS-intron	ENST00000351829	ENST00000373191	AKR1A1	chr1	46027550	+	AGO3	chr1	36469942	+
5CDS-intron	ENST00000351829	ENST00000397828	AKR1A1	chr1	46027550	+	AGO3	chr1	36469942	+
5CDS-5UTR	ENST00000351829	ENST00000246314	AKR1A1	chr1	46027550	+	AGO3	chr1	36469942	+
5CDS-intron	ENST00000351829	ENST00000471099	AKR1A1	chr1	46027550	+	AGO3	chr1	36469942	+
5CDS-intron	ENST00000471651	ENST00000324350	AKR1A1	chr1	46027550	+	AGO3	chr1	36469942	+
5CDS-intron	ENST00000471651	ENST00000373191	AKR1A1	chr1	46027550	+	AGO3	chr1	36469942	+
5CDS-intron	ENST00000471651	ENST00000397828	AKR1A1	chr1	46027550	+	AGO3	chr1	36469942	+
5CDS-5UTR	ENST00000471651	ENST00000246314	AKR1A1	chr1	46027550	+	AGO3	chr1	36469942	+
5CDS-intron	ENST00000471651	ENST00000471099	AKR1A1	chr1	46027550	+	AGO3	chr1	36469942	+
intron-intron	ENST00000473038	ENST00000324350	AKR1A1	chr1	46027550	+	AGO3	chr1	36469942	+
intron-intron	ENST00000473038	ENST00000373191	AKR1A1	chr1	46027550	+	AGO3	chr1	36469942	+
intron-intron	ENST00000473038	ENST00000397828	AKR1A1	chr1	46027550	+	AGO3	chr1	36469942	+
intron-5UTR	ENST00000473038	ENST00000246314	AKR1A1	chr1	46027550	+	AGO3	chr1	36469942	+
intron-intron	ENST00000473038	ENST00000471099	AKR1A1	chr1	46027550	+	AGO3	chr1	36469942	+

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FusionProtFeatures for AKR1A1_AGO3

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
AKR1A1 P14550	AGO3 Q9H9G7

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Fusion gene ID: 1389

FusionGeneSummary for AKR1A1_AGO3

FusionProtFeatures for AKR1A1_AGO3