	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 13824

FusionGeneSummary for FOXO3_PPP1R9A

Fusion gene summary

Fusion gene information	Fusion gene name: FOXO3_PPP1R9A
	Fusion gene ID: 13824
		Hgene	Tgene
	Gene symbol	FOXO3	PPP1R9A
	Gene ID	2309	55607
	Gene name	forkhead box O3	protein phosphatase 1 regulatory subunit 9A
	Synonyms	AF6q21\|FKHRL1\|FKHRL1P2\|FOXO2\|FOXO3A	NRB1\|NRBI\|Neurabin-I
	Cytomap	6q21	7q21.3
	Type of gene	protein-coding	protein-coding
	Description	forkhead box protein O3forkhead box O3Aforkhead homolog (rhabdomyosarcoma) like 1forkhead in rhabdomyosarcoma-like 1forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1	neurabin-1neural tissue-specific F-actin-binding protein Iprotein phosphatase 1, regulatory (inhibitor) subunit 9A
	Modification date	20180527	20180523
	UniProtAcc	O43524	Q9ULJ8
	Ensembl transtripts involved in fusion gene	ENST00000343882, ENST00000406360, ENST00000540898,	ENST00000433360, ENST00000340694, ENST00000424654, ENST00000433881, ENST00000289495, ENST00000456331,
Fusion gene scores	* DoF score	4 X 2 X 3=24	4 X 4 X 4=64
	# samples	4	4
	** MAII score	log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: FOXO3 [Title/Abstract] AND PPP1R9A [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation	Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	FOXO3	GO:0000122	negative regulation of transcription by RNA polymerase II	20371612
Hgene	FOXO3	GO:0006417	regulation of translation	21329882
Hgene	FOXO3	GO:0043065	positive regulation of apoptotic process	20371612
Hgene	FOXO3	GO:0045648	positive regulation of erythrocyte differentiation	14734530
Hgene	FOXO3	GO:0045893	positive regulation of transcription, DNA-templated	10102273\|15084260
Hgene	FOXO3	GO:0045944	positive regulation of transcription by RNA polymerase II	10102273\|14734530

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	BRCA	TCGA-AR-A0TS-01A	FOXO3	chr6	108883032	+	PPP1R9A	chr7	94876785	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000343882	ENST00000433360	FOXO3	chr6	108883032	+	PPP1R9A	chr7	94876785	+
In-frame	ENST00000343882	ENST00000340694	FOXO3	chr6	108883032	+	PPP1R9A	chr7	94876785	+
In-frame	ENST00000343882	ENST00000424654	FOXO3	chr6	108883032	+	PPP1R9A	chr7	94876785	+
In-frame	ENST00000343882	ENST00000433881	FOXO3	chr6	108883032	+	PPP1R9A	chr7	94876785	+
In-frame	ENST00000343882	ENST00000289495	FOXO3	chr6	108883032	+	PPP1R9A	chr7	94876785	+
In-frame	ENST00000343882	ENST00000456331	FOXO3	chr6	108883032	+	PPP1R9A	chr7	94876785	+
In-frame	ENST00000406360	ENST00000433360	FOXO3	chr6	108883032	+	PPP1R9A	chr7	94876785	+
In-frame	ENST00000406360	ENST00000340694	FOXO3	chr6	108883032	+	PPP1R9A	chr7	94876785	+
In-frame	ENST00000406360	ENST00000424654	FOXO3	chr6	108883032	+	PPP1R9A	chr7	94876785	+
In-frame	ENST00000406360	ENST00000433881	FOXO3	chr6	108883032	+	PPP1R9A	chr7	94876785	+
In-frame	ENST00000406360	ENST00000289495	FOXO3	chr6	108883032	+	PPP1R9A	chr7	94876785	+
In-frame	ENST00000406360	ENST00000456331	FOXO3	chr6	108883032	+	PPP1R9A	chr7	94876785	+
intron-3CDS	ENST00000540898	ENST00000433360	FOXO3	chr6	108883032	+	PPP1R9A	chr7	94876785	+
intron-3CDS	ENST00000540898	ENST00000340694	FOXO3	chr6	108883032	+	PPP1R9A	chr7	94876785	+
intron-3CDS	ENST00000540898	ENST00000424654	FOXO3	chr6	108883032	+	PPP1R9A	chr7	94876785	+
intron-3CDS	ENST00000540898	ENST00000433881	FOXO3	chr6	108883032	+	PPP1R9A	chr7	94876785	+
intron-3CDS	ENST00000540898	ENST00000289495	FOXO3	chr6	108883032	+	PPP1R9A	chr7	94876785	+
intron-3CDS	ENST00000540898	ENST00000456331	FOXO3	chr6	108883032	+	PPP1R9A	chr7	94876785	+

Top

FusionProtFeatures for FOXO3_PPP1R9A

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FOXO3 O43524	PPP1R9A Q9ULJ8

Home

Download

Statistics

Examples

Help

Contact

Fusion gene ID: 13824

FusionGeneSummary for FOXO3_PPP1R9A

FusionProtFeatures for FOXO3_PPP1R9A