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Fusion gene ID: 13809 |
FusionGeneSummary for FOXN3_FOXN3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FOXN3_FOXN3 | Fusion gene ID: 13809 | Hgene | Tgene | Gene symbol | FOXN3 | FOXN3 | Gene ID | 1112 | 1112 |
| Gene name | forkhead box N3 | forkhead box N3 | |
| Synonyms | C14orf116|CHES1|PRO1635 | C14orf116|CHES1|PRO1635 | |
| Cytomap | 14q31.3-q32.11 | 14q31.3-q32.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | forkhead box protein N3checkpoint suppressor 1 | forkhead box protein N3checkpoint suppressor 1 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | O00409 | O00409 | |
| Ensembl transtripts involved in fusion gene | ENST00000345097, ENST00000261302, ENST00000557258, ENST00000555353, ENST00000555658, | ENST00000345097, ENST00000261302, ENST00000557258, ENST00000555353, ENST00000555658, | |
| Fusion gene scores | * DoF score | 7 X 7 X 4=196 | 8 X 7 X 6=336 |
| # samples | 7 | 8 | |
| ** MAII score | log2(7/196*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/336*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FOXN3 [Title/Abstract] AND FOXN3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | FOXN3 | GO:0045892 | negative regulation of transcription, DNA-templated | 16102918 |
| Tgene | FOXN3 | GO:0045892 | negative regulation of transcription, DNA-templated | 16102918 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF367909 | FOXN3 | chr14 | 90047930 | - | FOXN3 | chr14 | 90047857 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000345097 | ENST00000345097 | FOXN3 | chr14 | 90047930 | - | FOXN3 | chr14 | 90047857 | + |
| intron-intron | ENST00000345097 | ENST00000261302 | FOXN3 | chr14 | 90047930 | - | FOXN3 | chr14 | 90047857 | + |
| intron-intron | ENST00000345097 | ENST00000557258 | FOXN3 | chr14 | 90047930 | - | FOXN3 | chr14 | 90047857 | + |
| intron-intron | ENST00000345097 | ENST00000555353 | FOXN3 | chr14 | 90047930 | - | FOXN3 | chr14 | 90047857 | + |
| intron-intron | ENST00000345097 | ENST00000555658 | FOXN3 | chr14 | 90047930 | - | FOXN3 | chr14 | 90047857 | + |
| intron-intron | ENST00000261302 | ENST00000345097 | FOXN3 | chr14 | 90047930 | - | FOXN3 | chr14 | 90047857 | + |
| intron-intron | ENST00000261302 | ENST00000261302 | FOXN3 | chr14 | 90047930 | - | FOXN3 | chr14 | 90047857 | + |
| intron-intron | ENST00000261302 | ENST00000557258 | FOXN3 | chr14 | 90047930 | - | FOXN3 | chr14 | 90047857 | + |
| intron-intron | ENST00000261302 | ENST00000555353 | FOXN3 | chr14 | 90047930 | - | FOXN3 | chr14 | 90047857 | + |
| intron-intron | ENST00000261302 | ENST00000555658 | FOXN3 | chr14 | 90047930 | - | FOXN3 | chr14 | 90047857 | + |
| intron-intron | ENST00000557258 | ENST00000345097 | FOXN3 | chr14 | 90047930 | - | FOXN3 | chr14 | 90047857 | + |
| intron-intron | ENST00000557258 | ENST00000261302 | FOXN3 | chr14 | 90047930 | - | FOXN3 | chr14 | 90047857 | + |
| intron-intron | ENST00000557258 | ENST00000557258 | FOXN3 | chr14 | 90047930 | - | FOXN3 | chr14 | 90047857 | + |
| intron-intron | ENST00000557258 | ENST00000555353 | FOXN3 | chr14 | 90047930 | - | FOXN3 | chr14 | 90047857 | + |
| intron-intron | ENST00000557258 | ENST00000555658 | FOXN3 | chr14 | 90047930 | - | FOXN3 | chr14 | 90047857 | + |
| intron-intron | ENST00000555353 | ENST00000345097 | FOXN3 | chr14 | 90047930 | - | FOXN3 | chr14 | 90047857 | + |
| intron-intron | ENST00000555353 | ENST00000261302 | FOXN3 | chr14 | 90047930 | - | FOXN3 | chr14 | 90047857 | + |
| intron-intron | ENST00000555353 | ENST00000557258 | FOXN3 | chr14 | 90047930 | - | FOXN3 | chr14 | 90047857 | + |
| intron-intron | ENST00000555353 | ENST00000555353 | FOXN3 | chr14 | 90047930 | - | FOXN3 | chr14 | 90047857 | + |
| intron-intron | ENST00000555353 | ENST00000555658 | FOXN3 | chr14 | 90047930 | - | FOXN3 | chr14 | 90047857 | + |
| intron-intron | ENST00000555658 | ENST00000345097 | FOXN3 | chr14 | 90047930 | - | FOXN3 | chr14 | 90047857 | + |
| intron-intron | ENST00000555658 | ENST00000261302 | FOXN3 | chr14 | 90047930 | - | FOXN3 | chr14 | 90047857 | + |
| intron-intron | ENST00000555658 | ENST00000557258 | FOXN3 | chr14 | 90047930 | - | FOXN3 | chr14 | 90047857 | + |
| intron-intron | ENST00000555658 | ENST00000555353 | FOXN3 | chr14 | 90047930 | - | FOXN3 | chr14 | 90047857 | + |
| intron-intron | ENST00000555658 | ENST00000555658 | FOXN3 | chr14 | 90047930 | - | FOXN3 | chr14 | 90047857 | + |
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FusionProtFeatures for FOXN3_FOXN3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FOXN3 | FOXN3 |