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Fusion gene ID: 1377 |
FusionGeneSummary for AKIRIN2_ANKRD55 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: AKIRIN2_ANKRD55 | Fusion gene ID: 1377 | Hgene | Tgene | Gene symbol | AKIRIN2 | ANKRD55 | Gene ID | 55122 | 79722 |
| Gene name | akirin 2 | ankyrin repeat domain 55 | |
| Synonyms | C6orf166|FBI1|dJ486L4.2 | - | |
| Cytomap | 6q15 | 5q11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | akirin-2fourteen-three-three beta interactant 1 | ankyrin repeat domain-containing protein 55 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q53H80 | Q3KP44 | |
| Ensembl transtripts involved in fusion gene | ENST00000257787, ENST00000420494, | ENST00000341048, ENST00000504958, ENST00000505970, ENST00000513241, ENST00000434982, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 5 X 3 X 4=60 |
| # samples | 3 | 5 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: AKIRIN2 [Title/Abstract] AND ANKRD55 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-A2-A1FW-01A | AKIRIN2 | chr6 | 88411168 | - | ANKRD55 | chr5 | 55479461 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000257787 | ENST00000341048 | AKIRIN2 | chr6 | 88411168 | - | ANKRD55 | chr5 | 55479461 | - |
| Frame-shift | ENST00000257787 | ENST00000504958 | AKIRIN2 | chr6 | 88411168 | - | ANKRD55 | chr5 | 55479461 | - |
| 5CDS-intron | ENST00000257787 | ENST00000505970 | AKIRIN2 | chr6 | 88411168 | - | ANKRD55 | chr5 | 55479461 | - |
| 5CDS-5UTR | ENST00000257787 | ENST00000513241 | AKIRIN2 | chr6 | 88411168 | - | ANKRD55 | chr5 | 55479461 | - |
| 5CDS-intron | ENST00000257787 | ENST00000434982 | AKIRIN2 | chr6 | 88411168 | - | ANKRD55 | chr5 | 55479461 | - |
| 5UTR-3CDS | ENST00000420494 | ENST00000341048 | AKIRIN2 | chr6 | 88411168 | - | ANKRD55 | chr5 | 55479461 | - |
| 5UTR-3CDS | ENST00000420494 | ENST00000504958 | AKIRIN2 | chr6 | 88411168 | - | ANKRD55 | chr5 | 55479461 | - |
| 5UTR-intron | ENST00000420494 | ENST00000505970 | AKIRIN2 | chr6 | 88411168 | - | ANKRD55 | chr5 | 55479461 | - |
| 5UTR-5UTR | ENST00000420494 | ENST00000513241 | AKIRIN2 | chr6 | 88411168 | - | ANKRD55 | chr5 | 55479461 | - |
| 5UTR-intron | ENST00000420494 | ENST00000434982 | AKIRIN2 | chr6 | 88411168 | - | ANKRD55 | chr5 | 55479461 | - |
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FusionProtFeatures for AKIRIN2_ANKRD55 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| AKIRIN2 | ANKRD55 |