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Fusion gene ID: 1376

FusionGeneSummary for AKIRIN1_SORBS1

Fusion gene summary

Fusion gene information	Fusion gene name: AKIRIN1_SORBS1
	Fusion gene ID: 1376
		Hgene	Tgene
	Gene symbol	AKIRIN1	SORBS1
	Gene ID	79647	10580
	Gene name	akirin 1	sorbin and SH3 domain containing 1
	Synonyms	C1orf108\|STRF2	CAP\|FLAF2\|R85FL\|SH3D5\|SH3P12\|SORB1
	Cytomap	1p34.3	10q24.1
	Type of gene	protein-coding	protein-coding
	Description	akirin-1	sorbin and SH3 domain-containing protein 1Fas-ligand associated factor 2SH3 domain protein 5c-Cbl associated proteinponsin
	Modification date	20180519	20180519
	UniProtAcc	Q9H9L7	Q9BX66
	Ensembl transtripts involved in fusion gene	ENST00000432648, ENST00000446189, ENST00000372984,	ENST00000371227, ENST00000371249, ENST00000306402, ENST00000353505, ENST00000371246, ENST00000347291, ENST00000393949, ENST00000371247, ENST00000607232, ENST00000371245, ENST00000361941, ENST00000277982, ENST00000354106, ENST00000371239, ENST00000371241, ENST00000474353,
Fusion gene scores	* DoF score	4 X 4 X 2=32	9 X 13 X 6=702
	# samples	4	16
	** MAII score	log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(16/702*10)=-2.1333991254172 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: AKIRIN1 [Title/Abstract] AND SORBS1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BF925553	AKIRIN1	chr1	39470360	-	SORBS1	chr10	97244375	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-intron	ENST00000432648	ENST00000371227	AKIRIN1	chr1	39470360	-	SORBS1	chr10	97244375	+
3UTR-intron	ENST00000432648	ENST00000371249	AKIRIN1	chr1	39470360	-	SORBS1	chr10	97244375	+
3UTR-intron	ENST00000432648	ENST00000306402	AKIRIN1	chr1	39470360	-	SORBS1	chr10	97244375	+
3UTR-intron	ENST00000432648	ENST00000353505	AKIRIN1	chr1	39470360	-	SORBS1	chr10	97244375	+
3UTR-intron	ENST00000432648	ENST00000371246	AKIRIN1	chr1	39470360	-	SORBS1	chr10	97244375	+
3UTR-intron	ENST00000432648	ENST00000347291	AKIRIN1	chr1	39470360	-	SORBS1	chr10	97244375	+
3UTR-intron	ENST00000432648	ENST00000393949	AKIRIN1	chr1	39470360	-	SORBS1	chr10	97244375	+
3UTR-intron	ENST00000432648	ENST00000371247	AKIRIN1	chr1	39470360	-	SORBS1	chr10	97244375	+
3UTR-intron	ENST00000432648	ENST00000607232	AKIRIN1	chr1	39470360	-	SORBS1	chr10	97244375	+
3UTR-intron	ENST00000432648	ENST00000371245	AKIRIN1	chr1	39470360	-	SORBS1	chr10	97244375	+
3UTR-intron	ENST00000432648	ENST00000361941	AKIRIN1	chr1	39470360	-	SORBS1	chr10	97244375	+
3UTR-intron	ENST00000432648	ENST00000277982	AKIRIN1	chr1	39470360	-	SORBS1	chr10	97244375	+
3UTR-intron	ENST00000432648	ENST00000354106	AKIRIN1	chr1	39470360	-	SORBS1	chr10	97244375	+
3UTR-intron	ENST00000432648	ENST00000371239	AKIRIN1	chr1	39470360	-	SORBS1	chr10	97244375	+
3UTR-intron	ENST00000432648	ENST00000371241	AKIRIN1	chr1	39470360	-	SORBS1	chr10	97244375	+
3UTR-intron	ENST00000432648	ENST00000474353	AKIRIN1	chr1	39470360	-	SORBS1	chr10	97244375	+
3UTR-intron	ENST00000446189	ENST00000371227	AKIRIN1	chr1	39470360	-	SORBS1	chr10	97244375	+
3UTR-intron	ENST00000446189	ENST00000371249	AKIRIN1	chr1	39470360	-	SORBS1	chr10	97244375	+
3UTR-intron	ENST00000446189	ENST00000306402	AKIRIN1	chr1	39470360	-	SORBS1	chr10	97244375	+
3UTR-intron	ENST00000446189	ENST00000353505	AKIRIN1	chr1	39470360	-	SORBS1	chr10	97244375	+
3UTR-intron	ENST00000446189	ENST00000371246	AKIRIN1	chr1	39470360	-	SORBS1	chr10	97244375	+
3UTR-intron	ENST00000446189	ENST00000347291	AKIRIN1	chr1	39470360	-	SORBS1	chr10	97244375	+
3UTR-intron	ENST00000446189	ENST00000393949	AKIRIN1	chr1	39470360	-	SORBS1	chr10	97244375	+
3UTR-intron	ENST00000446189	ENST00000371247	AKIRIN1	chr1	39470360	-	SORBS1	chr10	97244375	+
3UTR-intron	ENST00000446189	ENST00000607232	AKIRIN1	chr1	39470360	-	SORBS1	chr10	97244375	+
3UTR-intron	ENST00000446189	ENST00000371245	AKIRIN1	chr1	39470360	-	SORBS1	chr10	97244375	+
3UTR-intron	ENST00000446189	ENST00000361941	AKIRIN1	chr1	39470360	-	SORBS1	chr10	97244375	+
3UTR-intron	ENST00000446189	ENST00000277982	AKIRIN1	chr1	39470360	-	SORBS1	chr10	97244375	+
3UTR-intron	ENST00000446189	ENST00000354106	AKIRIN1	chr1	39470360	-	SORBS1	chr10	97244375	+
3UTR-intron	ENST00000446189	ENST00000371239	AKIRIN1	chr1	39470360	-	SORBS1	chr10	97244375	+
3UTR-intron	ENST00000446189	ENST00000371241	AKIRIN1	chr1	39470360	-	SORBS1	chr10	97244375	+
3UTR-intron	ENST00000446189	ENST00000474353	AKIRIN1	chr1	39470360	-	SORBS1	chr10	97244375	+
3UTR-intron	ENST00000372984	ENST00000371227	AKIRIN1	chr1	39470360	-	SORBS1	chr10	97244375	+
3UTR-intron	ENST00000372984	ENST00000371249	AKIRIN1	chr1	39470360	-	SORBS1	chr10	97244375	+
3UTR-intron	ENST00000372984	ENST00000306402	AKIRIN1	chr1	39470360	-	SORBS1	chr10	97244375	+
3UTR-intron	ENST00000372984	ENST00000353505	AKIRIN1	chr1	39470360	-	SORBS1	chr10	97244375	+
3UTR-intron	ENST00000372984	ENST00000371246	AKIRIN1	chr1	39470360	-	SORBS1	chr10	97244375	+
3UTR-intron	ENST00000372984	ENST00000347291	AKIRIN1	chr1	39470360	-	SORBS1	chr10	97244375	+
3UTR-intron	ENST00000372984	ENST00000393949	AKIRIN1	chr1	39470360	-	SORBS1	chr10	97244375	+
3UTR-intron	ENST00000372984	ENST00000371247	AKIRIN1	chr1	39470360	-	SORBS1	chr10	97244375	+
3UTR-intron	ENST00000372984	ENST00000607232	AKIRIN1	chr1	39470360	-	SORBS1	chr10	97244375	+
3UTR-intron	ENST00000372984	ENST00000371245	AKIRIN1	chr1	39470360	-	SORBS1	chr10	97244375	+
3UTR-intron	ENST00000372984	ENST00000361941	AKIRIN1	chr1	39470360	-	SORBS1	chr10	97244375	+
3UTR-intron	ENST00000372984	ENST00000277982	AKIRIN1	chr1	39470360	-	SORBS1	chr10	97244375	+
3UTR-intron	ENST00000372984	ENST00000354106	AKIRIN1	chr1	39470360	-	SORBS1	chr10	97244375	+
3UTR-intron	ENST00000372984	ENST00000371239	AKIRIN1	chr1	39470360	-	SORBS1	chr10	97244375	+
3UTR-intron	ENST00000372984	ENST00000371241	AKIRIN1	chr1	39470360	-	SORBS1	chr10	97244375	+
3UTR-intron	ENST00000372984	ENST00000474353	AKIRIN1	chr1	39470360	-	SORBS1	chr10	97244375	+

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FusionProtFeatures for AKIRIN1_SORBS1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
AKIRIN1 Q9H9L7	SORBS1 Q9BX66

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Fusion gene ID: 1376

FusionGeneSummary for AKIRIN1_SORBS1

FusionProtFeatures for AKIRIN1_SORBS1