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Fusion gene ID: 1372 |
FusionGeneSummary for AKIP1_F2R |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: AKIP1_F2R | Fusion gene ID: 1372 | Hgene | Tgene | Gene symbol | AKIP1 | F2R | Gene ID | 56672 | 2149 |
| Gene name | A-kinase interacting protein 1 | coagulation factor II thrombin receptor | |
| Synonyms | BCA3|C11orf17 | CF2R|HTR|PAR-1|PAR1|TR | |
| Cytomap | 11p15.4 | 5q13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | A-kinase-interacting protein 1A kinase (PRKA) interacting protein 1breast cancer associated gene 3koyt binding protein 1koyt binding protein 2koyt binding protein 3proline-rich protein BCA3 | proteinase-activated receptor 1protease-activated receptor 1 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9NQ31 | P25116 | |
| Ensembl transtripts involved in fusion gene | ENST00000299576, ENST00000309377, ENST00000309357, ENST00000529876, ENST00000525005, ENST00000534506, ENST00000396648, ENST00000534147, | ENST00000319211, ENST00000505600, | |
| Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 4 X 4 X 2=32 |
| # samples | 2 | 4 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: AKIP1 [Title/Abstract] AND F2R [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | F2R | GO:0002248 | connective tissue replacement involved in inflammatory response wound healing | 9639571 |
| Tgene | F2R | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | 10692450 |
| Tgene | F2R | GO:0007200 | phospholipase C-activating G-protein coupled receptor signaling pathway | 20164183 |
| Tgene | F2R | GO:0008285 | negative regulation of cell proliferation | 10692450 |
| Tgene | F2R | GO:0009611 | response to wounding | 9639571 |
| Tgene | F2R | GO:0030168 | platelet activation | 9038223 |
| Tgene | F2R | GO:0030193 | regulation of blood coagulation | 17848177 |
| Tgene | F2R | GO:0030194 | positive regulation of blood coagulation | 9038223 |
| Tgene | F2R | GO:0032967 | positive regulation of collagen biosynthetic process | 9639571 |
| Tgene | F2R | GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | 10692450 |
| Tgene | F2R | GO:0043410 | positive regulation of MAPK cascade | 17848177 |
| Tgene | F2R | GO:0045893 | positive regulation of transcription, DNA-templated | 17848177 |
| Tgene | F2R | GO:0051281 | positive regulation of release of sequestered calcium ion into cytosol | 1672265 |
| Tgene | F2R | GO:2000484 | positive regulation of interleukin-8 secretion | 17404307 |
| Tgene | F2R | GO:2000778 | positive regulation of interleukin-6 secretion | 11447194 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BX648821 | AKIP1 | chr11 | 8941118 | + | F2R | chr5 | 76031271 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3UTR | ENST00000299576 | ENST00000319211 | AKIP1 | chr11 | 8941118 | + | F2R | chr5 | 76031271 | + |
| 3UTR-intron | ENST00000299576 | ENST00000505600 | AKIP1 | chr11 | 8941118 | + | F2R | chr5 | 76031271 | + |
| 3UTR-3UTR | ENST00000309377 | ENST00000319211 | AKIP1 | chr11 | 8941118 | + | F2R | chr5 | 76031271 | + |
| 3UTR-intron | ENST00000309377 | ENST00000505600 | AKIP1 | chr11 | 8941118 | + | F2R | chr5 | 76031271 | + |
| 3UTR-3UTR | ENST00000309357 | ENST00000319211 | AKIP1 | chr11 | 8941118 | + | F2R | chr5 | 76031271 | + |
| 3UTR-intron | ENST00000309357 | ENST00000505600 | AKIP1 | chr11 | 8941118 | + | F2R | chr5 | 76031271 | + |
| intron-3UTR | ENST00000529876 | ENST00000319211 | AKIP1 | chr11 | 8941118 | + | F2R | chr5 | 76031271 | + |
| intron-intron | ENST00000529876 | ENST00000505600 | AKIP1 | chr11 | 8941118 | + | F2R | chr5 | 76031271 | + |
| intron-3UTR | ENST00000525005 | ENST00000319211 | AKIP1 | chr11 | 8941118 | + | F2R | chr5 | 76031271 | + |
| intron-intron | ENST00000525005 | ENST00000505600 | AKIP1 | chr11 | 8941118 | + | F2R | chr5 | 76031271 | + |
| intron-3UTR | ENST00000534506 | ENST00000319211 | AKIP1 | chr11 | 8941118 | + | F2R | chr5 | 76031271 | + |
| intron-intron | ENST00000534506 | ENST00000505600 | AKIP1 | chr11 | 8941118 | + | F2R | chr5 | 76031271 | + |
| 3UTR-3UTR | ENST00000396648 | ENST00000319211 | AKIP1 | chr11 | 8941118 | + | F2R | chr5 | 76031271 | + |
| 3UTR-intron | ENST00000396648 | ENST00000505600 | AKIP1 | chr11 | 8941118 | + | F2R | chr5 | 76031271 | + |
| 3UTR-3UTR | ENST00000534147 | ENST00000319211 | AKIP1 | chr11 | 8941118 | + | F2R | chr5 | 76031271 | + |
| 3UTR-intron | ENST00000534147 | ENST00000505600 | AKIP1 | chr11 | 8941118 | + | F2R | chr5 | 76031271 | + |
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FusionProtFeatures for AKIP1_F2R |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| AKIP1 | F2R |