	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 13697

FusionGeneSummary for FNDC3B_TPRG1

Fusion gene summary

Fusion gene information	Fusion gene name: FNDC3B_TPRG1
	Fusion gene ID: 13697
		Hgene	Tgene
	Gene symbol	FNDC3B	TPRG1
	Gene ID	64778	285386
	Gene name	fibronectin type III domain containing 3B	tumor protein p63 regulated 1
	Synonyms	FAD104\|PRO4979\|YVTM2421	FAM79B
	Cytomap	3q26.31	3q28
	Type of gene	protein-coding	protein-coding
	Description	fibronectin type III domain-containing protein 3BHCV NS5A-binding protein 37factor for adipocyte differentiation 104	tumor protein p63-regulated gene 1 proteinfamily with sequence similarity 79, member B
	Modification date	20180519	20180403
	UniProtAcc	Q53EP0	Q6ZUI0
	Ensembl transtripts involved in fusion gene	ENST00000415807, ENST00000336824, ENST00000416957, ENST00000392699, ENST00000421757, ENST00000423424, ENST00000476794,	ENST00000433971, ENST00000345063, ENST00000488841,
Fusion gene scores	* DoF score	22 X 10 X 13=2860	12 X 6 X 6=432
	# samples	24	13
	** MAII score	log2(24/2860*10)=-3.57490883605723 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/432*10)=-1.73251968913501 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: FNDC3B [Title/Abstract] AND TPRG1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	CESC	TCGA-C5-A8ZZ-01A	FNDC3B	chr3	171830380	+	TPRG1	chr3	189028175	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000415807	ENST00000433971	FNDC3B	chr3	171830380	+	TPRG1	chr3	189028175	+
Frame-shift	ENST00000415807	ENST00000345063	FNDC3B	chr3	171830380	+	TPRG1	chr3	189028175	+
5CDS-intron	ENST00000415807	ENST00000488841	FNDC3B	chr3	171830380	+	TPRG1	chr3	189028175	+
Frame-shift	ENST00000336824	ENST00000433971	FNDC3B	chr3	171830380	+	TPRG1	chr3	189028175	+
Frame-shift	ENST00000336824	ENST00000345063	FNDC3B	chr3	171830380	+	TPRG1	chr3	189028175	+
5CDS-intron	ENST00000336824	ENST00000488841	FNDC3B	chr3	171830380	+	TPRG1	chr3	189028175	+
Frame-shift	ENST00000416957	ENST00000433971	FNDC3B	chr3	171830380	+	TPRG1	chr3	189028175	+
Frame-shift	ENST00000416957	ENST00000345063	FNDC3B	chr3	171830380	+	TPRG1	chr3	189028175	+
5CDS-intron	ENST00000416957	ENST00000488841	FNDC3B	chr3	171830380	+	TPRG1	chr3	189028175	+
Frame-shift	ENST00000392699	ENST00000433971	FNDC3B	chr3	171830380	+	TPRG1	chr3	189028175	+
Frame-shift	ENST00000392699	ENST00000345063	FNDC3B	chr3	171830380	+	TPRG1	chr3	189028175	+
5CDS-intron	ENST00000392699	ENST00000488841	FNDC3B	chr3	171830380	+	TPRG1	chr3	189028175	+
Frame-shift	ENST00000421757	ENST00000433971	FNDC3B	chr3	171830380	+	TPRG1	chr3	189028175	+
Frame-shift	ENST00000421757	ENST00000345063	FNDC3B	chr3	171830380	+	TPRG1	chr3	189028175	+
5CDS-intron	ENST00000421757	ENST00000488841	FNDC3B	chr3	171830380	+	TPRG1	chr3	189028175	+
Frame-shift	ENST00000423424	ENST00000433971	FNDC3B	chr3	171830380	+	TPRG1	chr3	189028175	+
Frame-shift	ENST00000423424	ENST00000345063	FNDC3B	chr3	171830380	+	TPRG1	chr3	189028175	+
5CDS-intron	ENST00000423424	ENST00000488841	FNDC3B	chr3	171830380	+	TPRG1	chr3	189028175	+
intron-3CDS	ENST00000476794	ENST00000433971	FNDC3B	chr3	171830380	+	TPRG1	chr3	189028175	+
intron-3CDS	ENST00000476794	ENST00000345063	FNDC3B	chr3	171830380	+	TPRG1	chr3	189028175	+
intron-intron	ENST00000476794	ENST00000488841	FNDC3B	chr3	171830380	+	TPRG1	chr3	189028175	+

Top

FusionProtFeatures for FNDC3B_TPRG1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FNDC3B Q53EP0	TPRG1 Q6ZUI0

Home

Download

Statistics

Examples

Help

Contact

Fusion gene ID: 13697

FusionGeneSummary for FNDC3B_TPRG1

FusionProtFeatures for FNDC3B_TPRG1