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Fusion gene ID: 13662 |
FusionGeneSummary for FNBP1_GPT2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FNBP1_GPT2 | Fusion gene ID: 13662 | Hgene | Tgene | Gene symbol | FNBP1 | GPT2 | Gene ID | 23048 | 84706 |
| Gene name | formin binding protein 1 | glutamic--pyruvic transaminase 2 | |
| Synonyms | FBP17 | ALT2|GPT 2|MRT49 | |
| Cytomap | 9q34.11 | 16q11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | formin-binding protein 1formin-binding protein 17 | alanine aminotransferase 2glutamate pyruvate transaminase 2glutamic pyruvate transaminase (alanine aminotransferase) 2glutamic pyruvate transaminase 2glutamic--alanine transaminase 2 | |
| Modification date | 20180529 | 20180519 | |
| UniProtAcc | Q96RU3 | Q8TD30 | |
| Ensembl transtripts involved in fusion gene | ENST00000446176, ENST00000420781, ENST00000355681, ENST00000443566, ENST00000478129, | ENST00000340124, ENST00000440783, | |
| Fusion gene scores | * DoF score | 3 X 5 X 1=15 | 3 X 3 X 2=18 |
| # samples | 10 | 4 | |
| ** MAII score | log2(10/15*10)=2.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: FNBP1 [Title/Abstract] AND GPT2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | GPT2 | GO:0006103 | 2-oxoglutarate metabolic process | 11863375 |
| Tgene | GPT2 | GO:0042851 | L-alanine metabolic process | 11863375 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AA449654 | FNBP1 | chr9 | 132651026 | - | GPT2 | chr16 | 46965083 | + | ||
| ChiTaRS3.1 | CR742425 | FNBP1 | chr9 | 132651026 | - | GPT2 | chr16 | 46965083 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000446176 | ENST00000340124 | FNBP1 | chr9 | 132651026 | - | GPT2 | chr16 | 46965083 | + |
| intron-3UTR | ENST00000446176 | ENST00000440783 | FNBP1 | chr9 | 132651026 | - | GPT2 | chr16 | 46965083 | + |
| intron-3UTR | ENST00000420781 | ENST00000340124 | FNBP1 | chr9 | 132651026 | - | GPT2 | chr16 | 46965083 | + |
| intron-3UTR | ENST00000420781 | ENST00000440783 | FNBP1 | chr9 | 132651026 | - | GPT2 | chr16 | 46965083 | + |
| intron-3UTR | ENST00000355681 | ENST00000340124 | FNBP1 | chr9 | 132651026 | - | GPT2 | chr16 | 46965083 | + |
| intron-3UTR | ENST00000355681 | ENST00000440783 | FNBP1 | chr9 | 132651026 | - | GPT2 | chr16 | 46965083 | + |
| intron-3UTR | ENST00000443566 | ENST00000340124 | FNBP1 | chr9 | 132651026 | - | GPT2 | chr16 | 46965083 | + |
| intron-3UTR | ENST00000443566 | ENST00000440783 | FNBP1 | chr9 | 132651026 | - | GPT2 | chr16 | 46965083 | + |
| intron-3UTR | ENST00000478129 | ENST00000340124 | FNBP1 | chr9 | 132651026 | - | GPT2 | chr16 | 46965083 | + |
| intron-3UTR | ENST00000478129 | ENST00000440783 | FNBP1 | chr9 | 132651026 | - | GPT2 | chr16 | 46965083 | + |
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FusionProtFeatures for FNBP1_GPT2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FNBP1 | GPT2 |