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Fusion gene ID: 13607 |
FusionGeneSummary for FMN2_CHCHD6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FMN2_CHCHD6 | Fusion gene ID: 13607 | Hgene | Tgene | Gene symbol | FMN2 | CHCHD6 | Gene ID | 56776 | 84303 |
| Gene name | formin 2 | coiled-coil-helix-coiled-coil-helix domain containing 6 | |
| Synonyms | - | CHCM1|Mic25|PPP1R23 | |
| Cytomap | 1q43 | 3q21.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | formin-2 | MICOS complex subunit MIC25coiled coil helix cristae morphology 1coiled-coil-helix cristae morphology protein 1coiled-coil-helix-coiled-coil-helix domain-containing protein 6, mitochondrialprotein phosphatase 1, regulatory subunit 23 | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | Q9NZ56 | Q9BRQ6 | |
| Ensembl transtripts involved in fusion gene | ENST00000319653, ENST00000545751, ENST00000543681, ENST00000496950, | ENST00000290913, ENST00000508789, ENST00000515867, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 5 X 6 X 6=180 |
| # samples | 1 | 6 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(6/180*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FMN2 [Title/Abstract] AND CHCHD6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CHCHD6 | GO:0006974 | cellular response to DNA damage stimulus | 22228767 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | KIRC | TCGA-A3-3306-01A | FMN2 | chr1 | 240519208 | + | CHCHD6 | chr3 | 126499183 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000319653 | ENST00000290913 | FMN2 | chr1 | 240519208 | + | CHCHD6 | chr3 | 126499183 | + |
| 5CDS-intron | ENST00000319653 | ENST00000508789 | FMN2 | chr1 | 240519208 | + | CHCHD6 | chr3 | 126499183 | + |
| 5CDS-intron | ENST00000319653 | ENST00000515867 | FMN2 | chr1 | 240519208 | + | CHCHD6 | chr3 | 126499183 | + |
| 5CDS-intron | ENST00000545751 | ENST00000290913 | FMN2 | chr1 | 240519208 | + | CHCHD6 | chr3 | 126499183 | + |
| 5CDS-intron | ENST00000545751 | ENST00000508789 | FMN2 | chr1 | 240519208 | + | CHCHD6 | chr3 | 126499183 | + |
| 5CDS-intron | ENST00000545751 | ENST00000515867 | FMN2 | chr1 | 240519208 | + | CHCHD6 | chr3 | 126499183 | + |
| intron-intron | ENST00000543681 | ENST00000290913 | FMN2 | chr1 | 240519208 | + | CHCHD6 | chr3 | 126499183 | + |
| intron-intron | ENST00000543681 | ENST00000508789 | FMN2 | chr1 | 240519208 | + | CHCHD6 | chr3 | 126499183 | + |
| intron-intron | ENST00000543681 | ENST00000515867 | FMN2 | chr1 | 240519208 | + | CHCHD6 | chr3 | 126499183 | + |
| intron-intron | ENST00000496950 | ENST00000290913 | FMN2 | chr1 | 240519208 | + | CHCHD6 | chr3 | 126499183 | + |
| intron-intron | ENST00000496950 | ENST00000508789 | FMN2 | chr1 | 240519208 | + | CHCHD6 | chr3 | 126499183 | + |
| intron-intron | ENST00000496950 | ENST00000515867 | FMN2 | chr1 | 240519208 | + | CHCHD6 | chr3 | 126499183 | + |
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FusionProtFeatures for FMN2_CHCHD6 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FMN2 | CHCHD6 |