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Fusion gene ID: 13603 |
FusionGeneSummary for FMN1_SNAP23 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FMN1_SNAP23 | Fusion gene ID: 13603 | Hgene | Tgene | Gene symbol | FMN1 | SNAP23 | Gene ID | 342184 | 8773 |
| Gene name | formin 1 | synaptosome associated protein 23 | |
| Synonyms | FMN|LD | HsT17016|SNAP-23|SNAP23A|SNAP23B | |
| Cytomap | 15q13.3 | 15q15.1-q15.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | formin-1formin (limb deformity)limb deformity protein homolog | synaptosomal-associated protein 23synaptosomal-associated protein, 23kDsynaptosomal-associated protein, 23kDasynaptosome associated protein 23kDavesicle-membrane fusion protein SNAP-23 | |
| Modification date | 20180519 | 20180527 | |
| UniProtAcc | Q68DA7 | O00161 | |
| Ensembl transtripts involved in fusion gene | ENST00000334528, ENST00000561249, ENST00000559047, ENST00000558197, ENST00000559150, ENST00000320930, | ENST00000249647, ENST00000566141, ENST00000564153, ENST00000349777, ENST00000567094, ENST00000397138, | |
| Fusion gene scores | * DoF score | 9 X 6 X 5=270 | 6 X 6 X 4=144 |
| # samples | 9 | 6 | |
| ** MAII score | log2(9/270*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/144*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FMN1 [Title/Abstract] AND SNAP23 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SKCM | TCGA-DA-A95W-06A | FMN1 | chr15 | 33256308 | - | SNAP23 | chr15 | 42804031 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000334528 | ENST00000249647 | FMN1 | chr15 | 33256308 | - | SNAP23 | chr15 | 42804031 | + |
| 5CDS-intron | ENST00000334528 | ENST00000566141 | FMN1 | chr15 | 33256308 | - | SNAP23 | chr15 | 42804031 | + |
| 5CDS-5UTR | ENST00000334528 | ENST00000564153 | FMN1 | chr15 | 33256308 | - | SNAP23 | chr15 | 42804031 | + |
| 5CDS-5UTR | ENST00000334528 | ENST00000349777 | FMN1 | chr15 | 33256308 | - | SNAP23 | chr15 | 42804031 | + |
| 5CDS-5UTR | ENST00000334528 | ENST00000567094 | FMN1 | chr15 | 33256308 | - | SNAP23 | chr15 | 42804031 | + |
| 5CDS-intron | ENST00000334528 | ENST00000397138 | FMN1 | chr15 | 33256308 | - | SNAP23 | chr15 | 42804031 | + |
| 5CDS-5UTR | ENST00000561249 | ENST00000249647 | FMN1 | chr15 | 33256308 | - | SNAP23 | chr15 | 42804031 | + |
| 5CDS-intron | ENST00000561249 | ENST00000566141 | FMN1 | chr15 | 33256308 | - | SNAP23 | chr15 | 42804031 | + |
| 5CDS-5UTR | ENST00000561249 | ENST00000564153 | FMN1 | chr15 | 33256308 | - | SNAP23 | chr15 | 42804031 | + |
| 5CDS-5UTR | ENST00000561249 | ENST00000349777 | FMN1 | chr15 | 33256308 | - | SNAP23 | chr15 | 42804031 | + |
| 5CDS-5UTR | ENST00000561249 | ENST00000567094 | FMN1 | chr15 | 33256308 | - | SNAP23 | chr15 | 42804031 | + |
| 5CDS-intron | ENST00000561249 | ENST00000397138 | FMN1 | chr15 | 33256308 | - | SNAP23 | chr15 | 42804031 | + |
| 5CDS-5UTR | ENST00000559047 | ENST00000249647 | FMN1 | chr15 | 33256308 | - | SNAP23 | chr15 | 42804031 | + |
| 5CDS-intron | ENST00000559047 | ENST00000566141 | FMN1 | chr15 | 33256308 | - | SNAP23 | chr15 | 42804031 | + |
| 5CDS-5UTR | ENST00000559047 | ENST00000564153 | FMN1 | chr15 | 33256308 | - | SNAP23 | chr15 | 42804031 | + |
| 5CDS-5UTR | ENST00000559047 | ENST00000349777 | FMN1 | chr15 | 33256308 | - | SNAP23 | chr15 | 42804031 | + |
| 5CDS-5UTR | ENST00000559047 | ENST00000567094 | FMN1 | chr15 | 33256308 | - | SNAP23 | chr15 | 42804031 | + |
| 5CDS-intron | ENST00000559047 | ENST00000397138 | FMN1 | chr15 | 33256308 | - | SNAP23 | chr15 | 42804031 | + |
| intron-5UTR | ENST00000558197 | ENST00000249647 | FMN1 | chr15 | 33256308 | - | SNAP23 | chr15 | 42804031 | + |
| intron-intron | ENST00000558197 | ENST00000566141 | FMN1 | chr15 | 33256308 | - | SNAP23 | chr15 | 42804031 | + |
| intron-5UTR | ENST00000558197 | ENST00000564153 | FMN1 | chr15 | 33256308 | - | SNAP23 | chr15 | 42804031 | + |
| intron-5UTR | ENST00000558197 | ENST00000349777 | FMN1 | chr15 | 33256308 | - | SNAP23 | chr15 | 42804031 | + |
| intron-5UTR | ENST00000558197 | ENST00000567094 | FMN1 | chr15 | 33256308 | - | SNAP23 | chr15 | 42804031 | + |
| intron-intron | ENST00000558197 | ENST00000397138 | FMN1 | chr15 | 33256308 | - | SNAP23 | chr15 | 42804031 | + |
| intron-5UTR | ENST00000559150 | ENST00000249647 | FMN1 | chr15 | 33256308 | - | SNAP23 | chr15 | 42804031 | + |
| intron-intron | ENST00000559150 | ENST00000566141 | FMN1 | chr15 | 33256308 | - | SNAP23 | chr15 | 42804031 | + |
| intron-5UTR | ENST00000559150 | ENST00000564153 | FMN1 | chr15 | 33256308 | - | SNAP23 | chr15 | 42804031 | + |
| intron-5UTR | ENST00000559150 | ENST00000349777 | FMN1 | chr15 | 33256308 | - | SNAP23 | chr15 | 42804031 | + |
| intron-5UTR | ENST00000559150 | ENST00000567094 | FMN1 | chr15 | 33256308 | - | SNAP23 | chr15 | 42804031 | + |
| intron-intron | ENST00000559150 | ENST00000397138 | FMN1 | chr15 | 33256308 | - | SNAP23 | chr15 | 42804031 | + |
| intron-5UTR | ENST00000320930 | ENST00000249647 | FMN1 | chr15 | 33256308 | - | SNAP23 | chr15 | 42804031 | + |
| intron-intron | ENST00000320930 | ENST00000566141 | FMN1 | chr15 | 33256308 | - | SNAP23 | chr15 | 42804031 | + |
| intron-5UTR | ENST00000320930 | ENST00000564153 | FMN1 | chr15 | 33256308 | - | SNAP23 | chr15 | 42804031 | + |
| intron-5UTR | ENST00000320930 | ENST00000349777 | FMN1 | chr15 | 33256308 | - | SNAP23 | chr15 | 42804031 | + |
| intron-5UTR | ENST00000320930 | ENST00000567094 | FMN1 | chr15 | 33256308 | - | SNAP23 | chr15 | 42804031 | + |
| intron-intron | ENST00000320930 | ENST00000397138 | FMN1 | chr15 | 33256308 | - | SNAP23 | chr15 | 42804031 | + |
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FusionProtFeatures for FMN1_SNAP23 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FMN1 | SNAP23 |