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Fusion gene ID: 1359

FusionGeneSummary for AKAP9_AKAP9

Fusion gene summary

Fusion gene information	Fusion gene name: AKAP9_AKAP9
	Fusion gene ID: 1359
		Hgene	Tgene
	Gene symbol	AKAP9	AKAP9
	Gene ID	10142	10142
	Gene name	A-kinase anchoring protein 9	A-kinase anchoring protein 9
	Synonyms	AKAP-9\|AKAP350\|AKAP450\|CG-NAP\|HYPERION\|LQT11\|MU-RMS-40.16A\|PPP1R45\|PRKA9\|YOTIAO	AKAP-9\|AKAP350\|AKAP450\|CG-NAP\|HYPERION\|LQT11\|MU-RMS-40.16A\|PPP1R45\|PRKA9\|YOTIAO
	Cytomap	7q21.2	7q21.2
	Type of gene	protein-coding	protein-coding
	Description	A-kinase anchor protein 9A kinase (PRKA) anchor protein (yotiao) 9A kinase (PRKA) anchor protein 9A-kinase anchor protein 350 kDaA-kinase anchor protein 450 kDaAKAP 120-like proteinAKAP9-BRAF fusion proteincentrosome- and Golgi-localized PKN-associ	A-kinase anchor protein 9A kinase (PRKA) anchor protein (yotiao) 9A kinase (PRKA) anchor protein 9A-kinase anchor protein 350 kDaA-kinase anchor protein 450 kDaAKAP 120-like proteinAKAP9-BRAF fusion proteincentrosome- and Golgi-localized PKN-associ
	Modification date	20180523	20180523
	UniProtAcc	Q99996	Q99996
	Ensembl transtripts involved in fusion gene	ENST00000356239, ENST00000358100, ENST00000359028, ENST00000394564, ENST00000491695,	ENST00000356239, ENST00000358100, ENST00000359028, ENST00000394564, ENST00000491695,
Fusion gene scores	* DoF score	12 X 12 X 7=1008	7 X 9 X 5=315
	# samples	22	14
	** MAII score	log2(22/1008*10)=-2.19592020997526 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(14/315*10)=-1.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: AKAP9 [Title/Abstract] AND AKAP9 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	AKAP9	GO:1903358	regulation of Golgi organization	27666745
Tgene	AKAP9	GO:1903358	regulation of Golgi organization	27666745

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BM930492	AKAP9	chr7	91732433	+	AKAP9	chr7	91725926	+
ChiTaRS3.1			BM685013	AKAP9	chr7	91725926	-	AKAP9	chr7	91732433	-
ChiTaRS3.1			BQ187681	AKAP9	chr7	91732433	+	AKAP9	chr7	91725926	+
ChiTaRS3.1			CB177531	AKAP9	chr7	91630522	+	AKAP9	chr7	91622250	+
ChiTaRS3.1			BU743167	AKAP9	chr7	91725926	-	AKAP9	chr7	91732433	-
ChiTaRS3.1			BQ183998	AKAP9	chr7	91725926	-	AKAP9	chr7	91732433	-
ChiTaRS3.1			BU072746	AKAP9	chr7	91630522	+	AKAP9	chr7	91622250	+
ChiTaRS3.1			BQ184576	AKAP9	chr7	91725926	-	AKAP9	chr7	91732433	-

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000356239	ENST00000356239	AKAP9	chr7	91732433	+	AKAP9	chr7	91725926	+
intron-intron	ENST00000356239	ENST00000358100	AKAP9	chr7	91732433	+	AKAP9	chr7	91725926	+
intron-intron	ENST00000356239	ENST00000359028	AKAP9	chr7	91732433	+	AKAP9	chr7	91725926	+
intron-intron	ENST00000356239	ENST00000394564	AKAP9	chr7	91732433	+	AKAP9	chr7	91725926	+
intron-intron	ENST00000356239	ENST00000491695	AKAP9	chr7	91732433	+	AKAP9	chr7	91725926	+
intron-intron	ENST00000358100	ENST00000356239	AKAP9	chr7	91732433	+	AKAP9	chr7	91725926	+
intron-intron	ENST00000358100	ENST00000358100	AKAP9	chr7	91732433	+	AKAP9	chr7	91725926	+
intron-intron	ENST00000358100	ENST00000359028	AKAP9	chr7	91732433	+	AKAP9	chr7	91725926	+
intron-intron	ENST00000358100	ENST00000394564	AKAP9	chr7	91732433	+	AKAP9	chr7	91725926	+
intron-intron	ENST00000358100	ENST00000491695	AKAP9	chr7	91732433	+	AKAP9	chr7	91725926	+
intron-intron	ENST00000359028	ENST00000356239	AKAP9	chr7	91732433	+	AKAP9	chr7	91725926	+
intron-intron	ENST00000359028	ENST00000358100	AKAP9	chr7	91732433	+	AKAP9	chr7	91725926	+
intron-intron	ENST00000359028	ENST00000359028	AKAP9	chr7	91732433	+	AKAP9	chr7	91725926	+
intron-intron	ENST00000359028	ENST00000394564	AKAP9	chr7	91732433	+	AKAP9	chr7	91725926	+
intron-intron	ENST00000359028	ENST00000491695	AKAP9	chr7	91732433	+	AKAP9	chr7	91725926	+
intron-intron	ENST00000394564	ENST00000356239	AKAP9	chr7	91732433	+	AKAP9	chr7	91725926	+
intron-intron	ENST00000394564	ENST00000358100	AKAP9	chr7	91732433	+	AKAP9	chr7	91725926	+
intron-intron	ENST00000394564	ENST00000359028	AKAP9	chr7	91732433	+	AKAP9	chr7	91725926	+
intron-intron	ENST00000394564	ENST00000394564	AKAP9	chr7	91732433	+	AKAP9	chr7	91725926	+
intron-intron	ENST00000394564	ENST00000491695	AKAP9	chr7	91732433	+	AKAP9	chr7	91725926	+
intron-intron	ENST00000491695	ENST00000356239	AKAP9	chr7	91732433	+	AKAP9	chr7	91725926	+
intron-intron	ENST00000491695	ENST00000358100	AKAP9	chr7	91732433	+	AKAP9	chr7	91725926	+
intron-intron	ENST00000491695	ENST00000359028	AKAP9	chr7	91732433	+	AKAP9	chr7	91725926	+
intron-intron	ENST00000491695	ENST00000394564	AKAP9	chr7	91732433	+	AKAP9	chr7	91725926	+
intron-intron	ENST00000491695	ENST00000491695	AKAP9	chr7	91732433	+	AKAP9	chr7	91725926	+
intron-intron	ENST00000356239	ENST00000356239	AKAP9	chr7	91725926	-	AKAP9	chr7	91732433	-
intron-intron	ENST00000356239	ENST00000358100	AKAP9	chr7	91725926	-	AKAP9	chr7	91732433	-
intron-intron	ENST00000356239	ENST00000359028	AKAP9	chr7	91725926	-	AKAP9	chr7	91732433	-
intron-intron	ENST00000356239	ENST00000394564	AKAP9	chr7	91725926	-	AKAP9	chr7	91732433	-
intron-intron	ENST00000356239	ENST00000491695	AKAP9	chr7	91725926	-	AKAP9	chr7	91732433	-
intron-intron	ENST00000358100	ENST00000356239	AKAP9	chr7	91725926	-	AKAP9	chr7	91732433	-
intron-intron	ENST00000358100	ENST00000358100	AKAP9	chr7	91725926	-	AKAP9	chr7	91732433	-
intron-intron	ENST00000358100	ENST00000359028	AKAP9	chr7	91725926	-	AKAP9	chr7	91732433	-
intron-intron	ENST00000358100	ENST00000394564	AKAP9	chr7	91725926	-	AKAP9	chr7	91732433	-
intron-intron	ENST00000358100	ENST00000491695	AKAP9	chr7	91725926	-	AKAP9	chr7	91732433	-
intron-intron	ENST00000359028	ENST00000356239	AKAP9	chr7	91725926	-	AKAP9	chr7	91732433	-
intron-intron	ENST00000359028	ENST00000358100	AKAP9	chr7	91725926	-	AKAP9	chr7	91732433	-
intron-intron	ENST00000359028	ENST00000359028	AKAP9	chr7	91725926	-	AKAP9	chr7	91732433	-
intron-intron	ENST00000359028	ENST00000394564	AKAP9	chr7	91725926	-	AKAP9	chr7	91732433	-
intron-intron	ENST00000359028	ENST00000491695	AKAP9	chr7	91725926	-	AKAP9	chr7	91732433	-
intron-intron	ENST00000394564	ENST00000356239	AKAP9	chr7	91725926	-	AKAP9	chr7	91732433	-
intron-intron	ENST00000394564	ENST00000358100	AKAP9	chr7	91725926	-	AKAP9	chr7	91732433	-
intron-intron	ENST00000394564	ENST00000359028	AKAP9	chr7	91725926	-	AKAP9	chr7	91732433	-
intron-intron	ENST00000394564	ENST00000394564	AKAP9	chr7	91725926	-	AKAP9	chr7	91732433	-
intron-intron	ENST00000394564	ENST00000491695	AKAP9	chr7	91725926	-	AKAP9	chr7	91732433	-
intron-intron	ENST00000491695	ENST00000356239	AKAP9	chr7	91725926	-	AKAP9	chr7	91732433	-
intron-intron	ENST00000491695	ENST00000358100	AKAP9	chr7	91725926	-	AKAP9	chr7	91732433	-
intron-intron	ENST00000491695	ENST00000359028	AKAP9	chr7	91725926	-	AKAP9	chr7	91732433	-
intron-intron	ENST00000491695	ENST00000394564	AKAP9	chr7	91725926	-	AKAP9	chr7	91732433	-
intron-intron	ENST00000491695	ENST00000491695	AKAP9	chr7	91725926	-	AKAP9	chr7	91732433	-
In-frame	ENST00000356239	ENST00000356239	AKAP9	chr7	91630522	+	AKAP9	chr7	91622250	+
In-frame	ENST00000356239	ENST00000358100	AKAP9	chr7	91630522	+	AKAP9	chr7	91622250	+
In-frame	ENST00000356239	ENST00000359028	AKAP9	chr7	91630522	+	AKAP9	chr7	91622250	+
In-frame	ENST00000356239	ENST00000394564	AKAP9	chr7	91630522	+	AKAP9	chr7	91622250	+
5CDS-intron	ENST00000356239	ENST00000491695	AKAP9	chr7	91630522	+	AKAP9	chr7	91622250	+
In-frame	ENST00000358100	ENST00000356239	AKAP9	chr7	91630522	+	AKAP9	chr7	91622250	+
In-frame	ENST00000358100	ENST00000358100	AKAP9	chr7	91630522	+	AKAP9	chr7	91622250	+
In-frame	ENST00000358100	ENST00000359028	AKAP9	chr7	91630522	+	AKAP9	chr7	91622250	+
In-frame	ENST00000358100	ENST00000394564	AKAP9	chr7	91630522	+	AKAP9	chr7	91622250	+
5CDS-intron	ENST00000358100	ENST00000491695	AKAP9	chr7	91630522	+	AKAP9	chr7	91622250	+
In-frame	ENST00000359028	ENST00000356239	AKAP9	chr7	91630522	+	AKAP9	chr7	91622250	+
In-frame	ENST00000359028	ENST00000358100	AKAP9	chr7	91630522	+	AKAP9	chr7	91622250	+
In-frame	ENST00000359028	ENST00000359028	AKAP9	chr7	91630522	+	AKAP9	chr7	91622250	+
In-frame	ENST00000359028	ENST00000394564	AKAP9	chr7	91630522	+	AKAP9	chr7	91622250	+
5CDS-intron	ENST00000359028	ENST00000491695	AKAP9	chr7	91630522	+	AKAP9	chr7	91622250	+
intron-3CDS	ENST00000394564	ENST00000356239	AKAP9	chr7	91630522	+	AKAP9	chr7	91622250	+
intron-3CDS	ENST00000394564	ENST00000358100	AKAP9	chr7	91630522	+	AKAP9	chr7	91622250	+
intron-3CDS	ENST00000394564	ENST00000359028	AKAP9	chr7	91630522	+	AKAP9	chr7	91622250	+
intron-3CDS	ENST00000394564	ENST00000394564	AKAP9	chr7	91630522	+	AKAP9	chr7	91622250	+
intron-intron	ENST00000394564	ENST00000491695	AKAP9	chr7	91630522	+	AKAP9	chr7	91622250	+
intron-3CDS	ENST00000491695	ENST00000356239	AKAP9	chr7	91630522	+	AKAP9	chr7	91622250	+
intron-3CDS	ENST00000491695	ENST00000358100	AKAP9	chr7	91630522	+	AKAP9	chr7	91622250	+
intron-3CDS	ENST00000491695	ENST00000359028	AKAP9	chr7	91630522	+	AKAP9	chr7	91622250	+
intron-3CDS	ENST00000491695	ENST00000394564	AKAP9	chr7	91630522	+	AKAP9	chr7	91622250	+
intron-intron	ENST00000491695	ENST00000491695	AKAP9	chr7	91630522	+	AKAP9	chr7	91622250	+

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FusionProtFeatures for AKAP9_AKAP9

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
AKAP9 Q99996	AKAP9 Q99996

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Fusion gene ID: 1359

FusionGeneSummary for AKAP9_AKAP9

FusionProtFeatures for AKAP9_AKAP9