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Fusion gene ID: 1358 |
FusionGeneSummary for AKAP8_VMP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: AKAP8_VMP1 | Fusion gene ID: 1358 | Hgene | Tgene | Gene symbol | AKAP8 | VMP1 | Gene ID | 10270 | 81671 |
| Gene name | A-kinase anchoring protein 8 | vacuole membrane protein 1 | |
| Synonyms | AKAP 95|AKAP-8|AKAP-95|AKAP95 | EPG3|TANGO5|TMEM49 | |
| Cytomap | 19p13.12 | 17q23.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | A-kinase anchor protein 8A kinase (PRKA) anchor protein 8A-kinase anchor protein, 95kDa | vacuole membrane protein 1ectopic P-granules autophagy protein 3 homologtransmembrane protein 49transport and golgi organization 5 homolog | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O43823 | Q96GC9 | |
| Ensembl transtripts involved in fusion gene | ENST00000269701, | ENST00000262291, ENST00000537567, ENST00000539763, ENST00000536180, ENST00000545362, ENST00000588617, | |
| Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 24 X 11 X 12=3168 |
| # samples | 5 | 27 | |
| ** MAII score | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(27/3168*10)=-3.55254102302878 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: AKAP8 [Title/Abstract] AND VMP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-A8-A07L-01A | AKAP8 | chr19 | 15469778 | - | VMP1 | chr17 | 57842332 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000269701 | ENST00000262291 | AKAP8 | chr19 | 15469778 | - | VMP1 | chr17 | 57842332 | + |
| In-frame | ENST00000269701 | ENST00000537567 | AKAP8 | chr19 | 15469778 | - | VMP1 | chr17 | 57842332 | + |
| 5CDS-5UTR | ENST00000269701 | ENST00000539763 | AKAP8 | chr19 | 15469778 | - | VMP1 | chr17 | 57842332 | + |
| 5CDS-5UTR | ENST00000269701 | ENST00000536180 | AKAP8 | chr19 | 15469778 | - | VMP1 | chr17 | 57842332 | + |
| 5CDS-intron | ENST00000269701 | ENST00000545362 | AKAP8 | chr19 | 15469778 | - | VMP1 | chr17 | 57842332 | + |
| 5CDS-intron | ENST00000269701 | ENST00000588617 | AKAP8 | chr19 | 15469778 | - | VMP1 | chr17 | 57842332 | + |
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FusionProtFeatures for AKAP8_VMP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| AKAP8 | VMP1 |