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Fusion gene ID: 13565 |
FusionGeneSummary for FLNA_MGLL |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FLNA_MGLL | Fusion gene ID: 13565 | Hgene | Tgene | Gene symbol | FLNA | MGLL | Gene ID | 2316 | 11343 |
| Gene name | filamin A | monoglyceride lipase | |
| Synonyms | ABP-280|ABPX|CSBS|CVD1|FGS2|FLN|FLN-A|FLN1|FMD|MNS|NHBP|OPD|OPD1|OPD2|XLVD|XMVD | HU-K5|HUK5|MAGL|MGL | |
| Cytomap | Xq28 | 3q21.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | filamin-Aactin binding protein 280alpha-filaminendothelial actin-binding proteinfilamin A, alphafilamin-1non-muscle filamin | monoglyceride lipaselysophospholipase homologmonoacylglycerol lipase | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P21333 | Q99685 | |
| Ensembl transtripts involved in fusion gene | ENST00000360319, ENST00000422373, ENST00000369850, ENST00000369856, ENST00000344736, ENST00000498491, | ENST00000434178, ENST00000265052, ENST00000398104, ENST00000453507, ENST00000476682, ENST00000398101, | |
| Fusion gene scores | * DoF score | 18 X 21 X 7=2646 | 2 X 2 X 1=4 |
| # samples | 25 | 2 | |
| ** MAII score | log2(25/2646*10)=-3.40381306161659 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: FLNA [Title/Abstract] AND MGLL [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | FLNA | GO:0016479 | negative regulation of transcription by RNA polymerase I | 22307607 |
| Hgene | FLNA | GO:0030334 | regulation of cell migration | 16291724 |
| Hgene | FLNA | GO:0031532 | actin cytoskeleton reorganization | 10051605 |
| Hgene | FLNA | GO:0034394 | protein localization to cell surface | 18322202 |
| Hgene | FLNA | GO:0043113 | receptor clustering | 10692483 |
| Hgene | FLNA | GO:0043433 | negative regulation of DNA binding transcription factor activity | 15684392 |
| Hgene | FLNA | GO:0044319 | wound healing, spreading of cells | 16291724 |
| Hgene | FLNA | GO:0045184 | establishment of protein localization | 18322202 |
| Hgene | FLNA | GO:0051764 | actin crosslink formation | 10051605 |
| Hgene | FLNA | GO:0072659 | protein localization to plasma membrane | 24951510 |
| Hgene | FLNA | GO:0090307 | mitotic spindle assembly | 18548008 |
| Hgene | FLNA | GO:1901381 | positive regulation of potassium ion transmembrane transport | 24951510 |
| Tgene | MGLL | GO:0046464 | acylglycerol catabolic process | 22969151 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF819641 | FLNA | chrX | 153581464 | + | MGLL | chr3 | 127413933 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000360319 | ENST00000434178 | FLNA | chrX | 153581464 | + | MGLL | chr3 | 127413933 | - |
| intron-3CDS | ENST00000360319 | ENST00000265052 | FLNA | chrX | 153581464 | + | MGLL | chr3 | 127413933 | - |
| intron-3CDS | ENST00000360319 | ENST00000398104 | FLNA | chrX | 153581464 | + | MGLL | chr3 | 127413933 | - |
| intron-3CDS | ENST00000360319 | ENST00000453507 | FLNA | chrX | 153581464 | + | MGLL | chr3 | 127413933 | - |
| intron-5UTR | ENST00000360319 | ENST00000476682 | FLNA | chrX | 153581464 | + | MGLL | chr3 | 127413933 | - |
| intron-5UTR | ENST00000360319 | ENST00000398101 | FLNA | chrX | 153581464 | + | MGLL | chr3 | 127413933 | - |
| intron-3CDS | ENST00000422373 | ENST00000434178 | FLNA | chrX | 153581464 | + | MGLL | chr3 | 127413933 | - |
| intron-3CDS | ENST00000422373 | ENST00000265052 | FLNA | chrX | 153581464 | + | MGLL | chr3 | 127413933 | - |
| intron-3CDS | ENST00000422373 | ENST00000398104 | FLNA | chrX | 153581464 | + | MGLL | chr3 | 127413933 | - |
| intron-3CDS | ENST00000422373 | ENST00000453507 | FLNA | chrX | 153581464 | + | MGLL | chr3 | 127413933 | - |
| intron-5UTR | ENST00000422373 | ENST00000476682 | FLNA | chrX | 153581464 | + | MGLL | chr3 | 127413933 | - |
| intron-5UTR | ENST00000422373 | ENST00000398101 | FLNA | chrX | 153581464 | + | MGLL | chr3 | 127413933 | - |
| intron-3CDS | ENST00000369850 | ENST00000434178 | FLNA | chrX | 153581464 | + | MGLL | chr3 | 127413933 | - |
| intron-3CDS | ENST00000369850 | ENST00000265052 | FLNA | chrX | 153581464 | + | MGLL | chr3 | 127413933 | - |
| intron-3CDS | ENST00000369850 | ENST00000398104 | FLNA | chrX | 153581464 | + | MGLL | chr3 | 127413933 | - |
| intron-3CDS | ENST00000369850 | ENST00000453507 | FLNA | chrX | 153581464 | + | MGLL | chr3 | 127413933 | - |
| intron-5UTR | ENST00000369850 | ENST00000476682 | FLNA | chrX | 153581464 | + | MGLL | chr3 | 127413933 | - |
| intron-5UTR | ENST00000369850 | ENST00000398101 | FLNA | chrX | 153581464 | + | MGLL | chr3 | 127413933 | - |
| intron-3CDS | ENST00000369856 | ENST00000434178 | FLNA | chrX | 153581464 | + | MGLL | chr3 | 127413933 | - |
| intron-3CDS | ENST00000369856 | ENST00000265052 | FLNA | chrX | 153581464 | + | MGLL | chr3 | 127413933 | - |
| intron-3CDS | ENST00000369856 | ENST00000398104 | FLNA | chrX | 153581464 | + | MGLL | chr3 | 127413933 | - |
| intron-3CDS | ENST00000369856 | ENST00000453507 | FLNA | chrX | 153581464 | + | MGLL | chr3 | 127413933 | - |
| intron-5UTR | ENST00000369856 | ENST00000476682 | FLNA | chrX | 153581464 | + | MGLL | chr3 | 127413933 | - |
| intron-5UTR | ENST00000369856 | ENST00000398101 | FLNA | chrX | 153581464 | + | MGLL | chr3 | 127413933 | - |
| intron-3CDS | ENST00000344736 | ENST00000434178 | FLNA | chrX | 153581464 | + | MGLL | chr3 | 127413933 | - |
| intron-3CDS | ENST00000344736 | ENST00000265052 | FLNA | chrX | 153581464 | + | MGLL | chr3 | 127413933 | - |
| intron-3CDS | ENST00000344736 | ENST00000398104 | FLNA | chrX | 153581464 | + | MGLL | chr3 | 127413933 | - |
| intron-3CDS | ENST00000344736 | ENST00000453507 | FLNA | chrX | 153581464 | + | MGLL | chr3 | 127413933 | - |
| intron-5UTR | ENST00000344736 | ENST00000476682 | FLNA | chrX | 153581464 | + | MGLL | chr3 | 127413933 | - |
| intron-5UTR | ENST00000344736 | ENST00000398101 | FLNA | chrX | 153581464 | + | MGLL | chr3 | 127413933 | - |
| intron-3CDS | ENST00000498491 | ENST00000434178 | FLNA | chrX | 153581464 | + | MGLL | chr3 | 127413933 | - |
| intron-3CDS | ENST00000498491 | ENST00000265052 | FLNA | chrX | 153581464 | + | MGLL | chr3 | 127413933 | - |
| intron-3CDS | ENST00000498491 | ENST00000398104 | FLNA | chrX | 153581464 | + | MGLL | chr3 | 127413933 | - |
| intron-3CDS | ENST00000498491 | ENST00000453507 | FLNA | chrX | 153581464 | + | MGLL | chr3 | 127413933 | - |
| intron-5UTR | ENST00000498491 | ENST00000476682 | FLNA | chrX | 153581464 | + | MGLL | chr3 | 127413933 | - |
| intron-5UTR | ENST00000498491 | ENST00000398101 | FLNA | chrX | 153581464 | + | MGLL | chr3 | 127413933 | - |
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FusionProtFeatures for FLNA_MGLL |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FLNA | MGLL |