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Fusion gene ID: 1355 |
FusionGeneSummary for AKAP8_CALR3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: AKAP8_CALR3 | Fusion gene ID: 1355 | Hgene | Tgene | Gene symbol | AKAP8 | CALR3 | Gene ID | 10270 | 125972 |
| Gene name | A-kinase anchoring protein 8 | calreticulin 3 | |
| Synonyms | AKAP 95|AKAP-8|AKAP-95|AKAP95 | CMH19|CRT2|CT93 | |
| Cytomap | 19p13.12 | 19p13.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | A-kinase anchor protein 8A kinase (PRKA) anchor protein 8A-kinase anchor protein, 95kDa | calreticulin-3calreticulin-2calsperincancer/testis antigen 93testis secretory sperm-binding protein Li 226n | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | O43823 | Q96L12 | |
| Ensembl transtripts involved in fusion gene | ENST00000269701, | ENST00000269881, ENST00000602234, | |
| Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 3 X 3 X 4=36 |
| # samples | 5 | 5 | |
| ** MAII score | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/36*10)=0.473931188332412 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: AKAP8 [Title/Abstract] AND CALR3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-3B-A9HP-01A | AKAP8 | chr19 | 15487787 | - | CALR3 | chr19 | 16601381 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000269701 | ENST00000269881 | AKAP8 | chr19 | 15487787 | - | CALR3 | chr19 | 16601381 | - |
| 5CDS-intron | ENST00000269701 | ENST00000602234 | AKAP8 | chr19 | 15487787 | - | CALR3 | chr19 | 16601381 | - |
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FusionProtFeatures for AKAP8_CALR3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| AKAP8 | CALR3 |