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Center for Computational Systems Medicine
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FusionGeneSummary

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Fusion gene ID: 13502

FusionGeneSummary for FKBP1A_CDS2

check button Fusion gene summary
Fusion gene informationFusion gene name: FKBP1A_CDS2
Fusion gene ID: 13502
HgeneTgene
Gene symbol

FKBP1A

CDS2

Gene ID

2280

8760

Gene nameFK506 binding protein 1ACDP-diacylglycerol synthase 2
SynonymsFKBP-12|FKBP-1A|FKBP1|FKBP12|PKC12|PKCI2|PPIASE-
Cytomap

20p13

20p12.3

Type of geneprotein-codingprotein-coding
Descriptionpeptidyl-prolyl cis-trans isomerase FKBP1A12 kDa FK506-binding protein12 kDa FKBPFK506 binding protein 1A, 12kDaFK506 binding protein12FK506-binding protein 1FK506-binding protein 12FK506-binding protein, T-cell, 12-kDFKBP12-Exip3PPIase FKBP1Acaphosphatidate cytidylyltransferase 2CDP-DAG synthase 2CDP-DG synthase 2CDP-DG synthetase 2CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2CDP-diglyceride diphosphorylase 2CDP-diglyceride pyrophosphorylase 2CDP-diglyceride synthase
Modification date2018052320180523
UniProtAcc

P62942

O95674

Ensembl transtripts involved in fusion geneENST00000400137, ENST00000381724, 
ENST00000460490, ENST00000381719, 
ENST00000381715, ENST00000439640, 
ENST00000460006, ENST00000379062, 
ENST00000379070, ENST00000535100, 
Fusion gene scores* DoF score2 X 1 X 2=48 X 6 X 6=288
# samples 28
** MAII scorelog2(2/4*10)=2.32192809488736log2(8/288*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FKBP1A [Title/Abstract] AND CDS2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFKBP1A

GO:0000413

protein peptidyl-prolyl isomerization

1696686

HgeneFKBP1A

GO:0007183

SMAD protein complex assembly

16720724

HgeneFKBP1A

GO:0031398

positive regulation of protein ubiquitination

16720724

HgeneFKBP1A

GO:0032092

positive regulation of protein binding

18346205

HgeneFKBP1A

GO:0032515

negative regulation of phosphoprotein phosphatase activity

7592869

HgeneFKBP1A

GO:0032925

regulation of activin receptor signaling pathway

16720724

HgeneFKBP1A

GO:0051280

negative regulation of release of sequestered calcium ion into cytosol

12443530

HgeneFKBP1A

GO:0060314

regulation of ryanodine-sensitive calcium-release channel activity

7592869

HgeneFKBP1A

GO:0060315

negative regulation of ryanodine-sensitive calcium-release channel activity

12443530

HgeneFKBP1A

GO:0097435

supramolecular fiber organization

18346205

HgeneFKBP1A

GO:1990000

amyloid fibril formation

18346205


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVHNSCTCGA-CV-6937-01AFKBP1Achr20

1373478

-CDS2chr20

5169713

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000400137ENST00000460006FKBP1Achr20

1373478

-CDS2chr20

5169713

+
In-frameENST00000400137ENST00000379062FKBP1Achr20

1373478

-CDS2chr20

5169713

+
5CDS-3UTRENST00000400137ENST00000379070FKBP1Achr20

1373478

-CDS2chr20

5169713

+
5CDS-3UTRENST00000400137ENST00000535100FKBP1Achr20

1373478

-CDS2chr20

5169713

+
In-frameENST00000381724ENST00000460006FKBP1Achr20

1373478

-CDS2chr20

5169713

+
In-frameENST00000381724ENST00000379062FKBP1Achr20

1373478

-CDS2chr20

5169713

+
5CDS-3UTRENST00000381724ENST00000379070FKBP1Achr20

1373478

-CDS2chr20

5169713

+
5CDS-3UTRENST00000381724ENST00000535100FKBP1Achr20

1373478

-CDS2chr20

5169713

+
intron-3CDSENST00000460490ENST00000460006FKBP1Achr20

1373478

-CDS2chr20

5169713

+
intron-3CDSENST00000460490ENST00000379062FKBP1Achr20

1373478

-CDS2chr20

5169713

+
intron-3UTRENST00000460490ENST00000379070FKBP1Achr20

1373478

-CDS2chr20

5169713

+
intron-3UTRENST00000460490ENST00000535100FKBP1Achr20

1373478

-CDS2chr20

5169713

+
Frame-shiftENST00000381719ENST00000460006FKBP1Achr20

1373478

-CDS2chr20

5169713

+
Frame-shiftENST00000381719ENST00000379062FKBP1Achr20

1373478

-CDS2chr20

5169713

+
5CDS-3UTRENST00000381719ENST00000379070FKBP1Achr20

1373478

-CDS2chr20

5169713

+
5CDS-3UTRENST00000381719ENST00000535100FKBP1Achr20

1373478

-CDS2chr20

5169713

+
In-frameENST00000381715ENST00000460006FKBP1Achr20

1373478

-CDS2chr20

5169713

+
In-frameENST00000381715ENST00000379062FKBP1Achr20

1373478

-CDS2chr20

5169713

+
5CDS-3UTRENST00000381715ENST00000379070FKBP1Achr20

1373478

-CDS2chr20

5169713

+
5CDS-3UTRENST00000381715ENST00000535100FKBP1Achr20

1373478

-CDS2chr20

5169713

+
intron-3CDSENST00000439640ENST00000460006FKBP1Achr20

1373478

-CDS2chr20

5169713

+
intron-3CDSENST00000439640ENST00000379062FKBP1Achr20

1373478

-CDS2chr20

5169713

+
intron-3UTRENST00000439640ENST00000379070FKBP1Achr20

1373478

-CDS2chr20

5169713

+
intron-3UTRENST00000439640ENST00000535100FKBP1Achr20

1373478

-CDS2chr20

5169713

+

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FusionProtFeatures for FKBP1A_CDS2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FKBP1A

P62942

CDS2

O95674