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Fusion gene ID: 135 |
FusionGeneSummary for ABCC10_CUL9 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ABCC10_CUL9 | Fusion gene ID: 135 | Hgene | Tgene | Gene symbol | ABCC10 | CUL9 | Gene ID | 89845 | 23113 |
| Gene name | ATP binding cassette subfamily C member 10 | cullin 9 | |
| Synonyms | EST182763|MRP7|SIMRP7 | H7AP1|PARC | |
| Cytomap | 6p21.1 | 6p21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | multidrug resistance-associated protein 7ATP-binding cassette sub-family C member 10ATP-binding cassette, sub-family C (CFTR/MRP), member 10 | cullin-9CUL-9UbcH7-associated protein 1p53-associated parkin-like cytoplasmic proteinparkin-like cytoplasmic p53 binding protein | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q5T3U5 | Q8IWT3 | |
| Ensembl transtripts involved in fusion gene | ENST00000372530, ENST00000443426, ENST00000244533, | ENST00000252050, ENST00000354495, ENST00000372647, ENST00000502937, | |
| Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 4 X 4 X 2=32 |
| # samples | 4 | 4 | |
| ** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ABCC10 [Title/Abstract] AND CUL9 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CUL9 | GO:0016567 | protein ubiquitination | 24793696 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DA875626 | ABCC10 | chr6 | 43395708 | + | CUL9 | chr6 | 43182814 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000372530 | ENST00000252050 | ABCC10 | chr6 | 43395708 | + | CUL9 | chr6 | 43182814 | + |
| intron-3CDS | ENST00000372530 | ENST00000354495 | ABCC10 | chr6 | 43395708 | + | CUL9 | chr6 | 43182814 | + |
| intron-3CDS | ENST00000372530 | ENST00000372647 | ABCC10 | chr6 | 43395708 | + | CUL9 | chr6 | 43182814 | + |
| intron-intron | ENST00000372530 | ENST00000502937 | ABCC10 | chr6 | 43395708 | + | CUL9 | chr6 | 43182814 | + |
| 3UTR-3CDS | ENST00000443426 | ENST00000252050 | ABCC10 | chr6 | 43395708 | + | CUL9 | chr6 | 43182814 | + |
| 3UTR-3CDS | ENST00000443426 | ENST00000354495 | ABCC10 | chr6 | 43395708 | + | CUL9 | chr6 | 43182814 | + |
| 3UTR-3CDS | ENST00000443426 | ENST00000372647 | ABCC10 | chr6 | 43395708 | + | CUL9 | chr6 | 43182814 | + |
| 3UTR-intron | ENST00000443426 | ENST00000502937 | ABCC10 | chr6 | 43395708 | + | CUL9 | chr6 | 43182814 | + |
| intron-3CDS | ENST00000244533 | ENST00000252050 | ABCC10 | chr6 | 43395708 | + | CUL9 | chr6 | 43182814 | + |
| intron-3CDS | ENST00000244533 | ENST00000354495 | ABCC10 | chr6 | 43395708 | + | CUL9 | chr6 | 43182814 | + |
| intron-3CDS | ENST00000244533 | ENST00000372647 | ABCC10 | chr6 | 43395708 | + | CUL9 | chr6 | 43182814 | + |
| intron-intron | ENST00000244533 | ENST00000502937 | ABCC10 | chr6 | 43395708 | + | CUL9 | chr6 | 43182814 | + |
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FusionProtFeatures for ABCC10_CUL9 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ABCC10 | CUL9 |