FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 13482

FusionGeneSummary for FIP1L1_PDGFRA

check button Fusion gene summary
Fusion gene informationFusion gene name: FIP1L1_PDGFRA
Fusion gene ID: 13482
HgeneTgene
Gene symbol

FIP1L1

PDGFRA

Gene ID

81608

5156

Gene namefactor interacting with PAPOLA and CPSF1platelet derived growth factor receptor alpha
SynonymsFIP1|Rhe|hFip1CD140A|PDGFR-2|PDGFR2
Cytomap

4q12

4q12

Type of geneprotein-codingprotein-coding
Descriptionpre-mRNA 3'-end-processing factor FIP1FIP1 like 1FIP1-like 1 proteinFIP1L1 cleavage and polyadenylation specific factor subunitfactor interacting with PAPrearranged in hypereosinophiliaplatelet-derived growth factor receptor alphaCD140 antigen-like family member ACD140a antigenPDGF-R-alphaalpha-type platelet-derived growth factor receptorplatelet-derived growth factor receptor 2platelet-derived growth factor receptor, alpha polype
Modification date2018052320180523
UniProtAcc

Q6UN15

P16234

Ensembl transtripts involved in fusion geneENST00000507166, ENST00000358575, 
ENST00000337488, ENST00000507922, 
ENST00000306932, ENST00000510668, 
ENST00000257290, ENST00000508170, 
Fusion gene scores* DoF score7 X 8 X 5=28012 X 13 X 4=624
# samples 1013
** MAII scorelog2(10/280*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/624*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FIP1L1 [Title/Abstract] AND PDGFRA [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePDGFRA

GO:0008284

positive regulation of cell proliferation

10806482

TgenePDGFRA

GO:0010544

negative regulation of platelet activation

8188664

TgenePDGFRA

GO:0018108

peptidyl-tyrosine phosphorylation

1646396|2536956|8188664

TgenePDGFRA

GO:0030335

positive regulation of cell migration

17470632

TgenePDGFRA

GO:0034614

cellular response to reactive oxygen species

24190966

TgenePDGFRA

GO:0038091

positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway

17470632

TgenePDGFRA

GO:0046777

protein autophosphorylation

1646396|2536956|8188664

TgenePDGFRA

GO:0048008

platelet-derived growth factor receptor signaling pathway

2536956|10806482

TgenePDGFRA

GO:0048146

positive regulation of fibroblast proliferation

10806482


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DB355043FIP1L1chr4

54324852

-PDGFRAchr4

54327780

-
ChiTaRS3.1AY229892FIP1L1chr4

54292132

+PDGFRAchr4

55141089

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000507166ENST00000257290FIP1L1chr4

54324852

-PDGFRAchr4

54327780

-
intron-intronENST00000507166ENST00000508170FIP1L1chr4

54324852

-PDGFRAchr4

54327780

-
5CDS-intronENST00000358575ENST00000257290FIP1L1chr4

54324852

-PDGFRAchr4

54327780

-
5CDS-intronENST00000358575ENST00000508170FIP1L1chr4

54324852

-PDGFRAchr4

54327780

-
5CDS-intronENST00000337488ENST00000257290FIP1L1chr4

54324852

-PDGFRAchr4

54327780

-
5CDS-intronENST00000337488ENST00000508170FIP1L1chr4

54324852

-PDGFRAchr4

54327780

-
intron-intronENST00000507922ENST00000257290FIP1L1chr4

54324852

-PDGFRAchr4

54327780

-
intron-intronENST00000507922ENST00000508170FIP1L1chr4

54324852

-PDGFRAchr4

54327780

-
5CDS-intronENST00000306932ENST00000257290FIP1L1chr4

54324852

-PDGFRAchr4

54327780

-
5CDS-intronENST00000306932ENST00000508170FIP1L1chr4

54324852

-PDGFRAchr4

54327780

-
intron-intronENST00000510668ENST00000257290FIP1L1chr4

54324852

-PDGFRAchr4

54327780

-
intron-intronENST00000510668ENST00000508170FIP1L1chr4

54324852

-PDGFRAchr4

54327780

-
In-frameENST00000507166ENST00000257290FIP1L1chr4

54292132

+PDGFRAchr4

55141089

+
5CDS-intronENST00000507166ENST00000508170FIP1L1chr4

54292132

+PDGFRAchr4

55141089

+
In-frameENST00000358575ENST00000257290FIP1L1chr4

54292132

+PDGFRAchr4

55141089

+
5CDS-intronENST00000358575ENST00000508170FIP1L1chr4

54292132

+PDGFRAchr4

55141089

+
In-frameENST00000337488ENST00000257290FIP1L1chr4

54292132

+PDGFRAchr4

55141089

+
5CDS-intronENST00000337488ENST00000508170FIP1L1chr4

54292132

+PDGFRAchr4

55141089

+
In-frameENST00000507922ENST00000257290FIP1L1chr4

54292132

+PDGFRAchr4

55141089

+
5CDS-intronENST00000507922ENST00000508170FIP1L1chr4

54292132

+PDGFRAchr4

55141089

+
In-frameENST00000306932ENST00000257290FIP1L1chr4

54292132

+PDGFRAchr4

55141089

+
5CDS-intronENST00000306932ENST00000508170FIP1L1chr4

54292132

+PDGFRAchr4

55141089

+
intron-3CDSENST00000510668ENST00000257290FIP1L1chr4

54292132

+PDGFRAchr4

55141089

+
intron-intronENST00000510668ENST00000508170FIP1L1chr4

54292132

+PDGFRAchr4

55141089

+

Top

FusionProtFeatures for FIP1L1_PDGFRA


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FIP1L1

Q6UN15

PDGFRA

P16234