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Fusion gene ID: 13479

FusionGeneSummary for FILIP1_KCNQ5

Fusion gene summary

Fusion gene information	Fusion gene name: FILIP1_KCNQ5
	Fusion gene ID: 13479
		Hgene	Tgene
	Gene symbol	FILIP1	KCNQ5
	Gene ID	27145	56479
	Gene name	filamin A interacting protein 1	potassium voltage-gated channel subfamily Q member 5
	Synonyms	FILIP	Kv7.5\|MRD46
	Cytomap	6q14.1	6q13
	Type of gene	protein-coding	protein-coding
	Description	filamin-A-interacting protein 1	potassium voltage-gated channel subfamily KQT member 5KQT-like 5potassium channel proteinpotassium channel subunit alpha KvLQT5potassium channel, voltage gated KQT-like subfamily Q, member 5voltage-gated potassium channel subunit Kv7.5
	Modification date	20180523	20180523
	UniProtAcc	Q7Z7B0	Q9NR82
	Ensembl transtripts involved in fusion gene	ENST00000393004, ENST00000237172, ENST00000498523, ENST00000370020,	ENST00000342056, ENST00000355194, ENST00000370398, ENST00000370392, ENST00000355635, ENST00000414165, ENST00000402622, ENST00000403813,
Fusion gene scores	* DoF score	2 X 2 X 2=8	4 X 4 X 3=48
	# samples	2	4
	** MAII score	log2(2/8*10)=1.32192809488736	log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: FILIP1 [Title/Abstract] AND KCNQ5 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	KCNQ5	GO:0071805	potassium ion transmembrane transport	10787416\|11159685

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	UVM	TCGA-VD-A8KJ-01A	FILIP1	chr6	76124413	-	KCNQ5	chr6	73814980	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000393004	ENST00000342056	FILIP1	chr6	76124413	-	KCNQ5	chr6	73814980	+
In-frame	ENST00000393004	ENST00000355194	FILIP1	chr6	76124413	-	KCNQ5	chr6	73814980	+
In-frame	ENST00000393004	ENST00000370398	FILIP1	chr6	76124413	-	KCNQ5	chr6	73814980	+
In-frame	ENST00000393004	ENST00000370392	FILIP1	chr6	76124413	-	KCNQ5	chr6	73814980	+
In-frame	ENST00000393004	ENST00000355635	FILIP1	chr6	76124413	-	KCNQ5	chr6	73814980	+
In-frame	ENST00000393004	ENST00000414165	FILIP1	chr6	76124413	-	KCNQ5	chr6	73814980	+
In-frame	ENST00000393004	ENST00000402622	FILIP1	chr6	76124413	-	KCNQ5	chr6	73814980	+
In-frame	ENST00000393004	ENST00000403813	FILIP1	chr6	76124413	-	KCNQ5	chr6	73814980	+
In-frame	ENST00000237172	ENST00000342056	FILIP1	chr6	76124413	-	KCNQ5	chr6	73814980	+
In-frame	ENST00000237172	ENST00000355194	FILIP1	chr6	76124413	-	KCNQ5	chr6	73814980	+
In-frame	ENST00000237172	ENST00000370398	FILIP1	chr6	76124413	-	KCNQ5	chr6	73814980	+
In-frame	ENST00000237172	ENST00000370392	FILIP1	chr6	76124413	-	KCNQ5	chr6	73814980	+
In-frame	ENST00000237172	ENST00000355635	FILIP1	chr6	76124413	-	KCNQ5	chr6	73814980	+
In-frame	ENST00000237172	ENST00000414165	FILIP1	chr6	76124413	-	KCNQ5	chr6	73814980	+
In-frame	ENST00000237172	ENST00000402622	FILIP1	chr6	76124413	-	KCNQ5	chr6	73814980	+
In-frame	ENST00000237172	ENST00000403813	FILIP1	chr6	76124413	-	KCNQ5	chr6	73814980	+
intron-3CDS	ENST00000498523	ENST00000342056	FILIP1	chr6	76124413	-	KCNQ5	chr6	73814980	+
intron-3CDS	ENST00000498523	ENST00000355194	FILIP1	chr6	76124413	-	KCNQ5	chr6	73814980	+
intron-3CDS	ENST00000498523	ENST00000370398	FILIP1	chr6	76124413	-	KCNQ5	chr6	73814980	+
intron-3CDS	ENST00000498523	ENST00000370392	FILIP1	chr6	76124413	-	KCNQ5	chr6	73814980	+
intron-3CDS	ENST00000498523	ENST00000355635	FILIP1	chr6	76124413	-	KCNQ5	chr6	73814980	+
intron-3CDS	ENST00000498523	ENST00000414165	FILIP1	chr6	76124413	-	KCNQ5	chr6	73814980	+
intron-3CDS	ENST00000498523	ENST00000402622	FILIP1	chr6	76124413	-	KCNQ5	chr6	73814980	+
intron-3CDS	ENST00000498523	ENST00000403813	FILIP1	chr6	76124413	-	KCNQ5	chr6	73814980	+
intron-3CDS	ENST00000370020	ENST00000342056	FILIP1	chr6	76124413	-	KCNQ5	chr6	73814980	+
intron-3CDS	ENST00000370020	ENST00000355194	FILIP1	chr6	76124413	-	KCNQ5	chr6	73814980	+
intron-3CDS	ENST00000370020	ENST00000370398	FILIP1	chr6	76124413	-	KCNQ5	chr6	73814980	+
intron-3CDS	ENST00000370020	ENST00000370392	FILIP1	chr6	76124413	-	KCNQ5	chr6	73814980	+
intron-3CDS	ENST00000370020	ENST00000355635	FILIP1	chr6	76124413	-	KCNQ5	chr6	73814980	+
intron-3CDS	ENST00000370020	ENST00000414165	FILIP1	chr6	76124413	-	KCNQ5	chr6	73814980	+
intron-3CDS	ENST00000370020	ENST00000402622	FILIP1	chr6	76124413	-	KCNQ5	chr6	73814980	+
intron-3CDS	ENST00000370020	ENST00000403813	FILIP1	chr6	76124413	-	KCNQ5	chr6	73814980	+

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FusionProtFeatures for FILIP1_KCNQ5

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FILIP1 Q7Z7B0	KCNQ5 Q9NR82

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Fusion gene ID: 13479

FusionGeneSummary for FILIP1_KCNQ5

FusionProtFeatures for FILIP1_KCNQ5