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Fusion gene ID: 13459 |
FusionGeneSummary for FHL2_TNKS1BP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FHL2_TNKS1BP1 | Fusion gene ID: 13459 | Hgene | Tgene | Gene symbol | FHL2 | TNKS1BP1 | Gene ID | 2274 | 85456 |
| Gene name | four and a half LIM domains 2 | tankyrase 1 binding protein 1 | |
| Synonyms | AAG11|DRAL|FHL-2|SLIM-3|SLIM3 | TAB182 | |
| Cytomap | 2q12.2 | 11q12.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | four and a half LIM domains protein 2LIM domain protein DRALaging-associated gene 11down-regulated in rhabdomyosarcoma LIM proteinskeletal muscle LIM-protein 3 | 182 kDa tankyrase-1-binding proteintankyrase 1 binding protein 1, 182kDatankyrase 1-binding protein of 182 kDatestis secretory sperm-binding protein Li 206a | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q14192 | Q9C0C2 | |
| Ensembl transtripts involved in fusion gene | ENST00000393352, ENST00000336660, ENST00000607522, ENST00000409177, ENST00000344213, ENST00000393353, ENST00000322142, ENST00000358129, ENST00000409807, ENST00000408995, | ENST00000358252, ENST00000532437, ENST00000530920, | |
| Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 6 X 6 X 2=72 |
| # samples | 2 | 6 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(6/72*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FHL2 [Title/Abstract] AND TNKS1BP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | FHL2 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 15692560 |
| Hgene | FHL2 | GO:0043066 | negative regulation of apoptotic process | 15692560 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF844047 | FHL2 | chr2 | 106025429 | + | TNKS1BP1 | chr11 | 57067473 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000393352 | ENST00000358252 | FHL2 | chr2 | 106025429 | + | TNKS1BP1 | chr11 | 57067473 | - |
| intron-3UTR | ENST00000393352 | ENST00000532437 | FHL2 | chr2 | 106025429 | + | TNKS1BP1 | chr11 | 57067473 | - |
| intron-intron | ENST00000393352 | ENST00000530920 | FHL2 | chr2 | 106025429 | + | TNKS1BP1 | chr11 | 57067473 | - |
| intron-3UTR | ENST00000336660 | ENST00000358252 | FHL2 | chr2 | 106025429 | + | TNKS1BP1 | chr11 | 57067473 | - |
| intron-3UTR | ENST00000336660 | ENST00000532437 | FHL2 | chr2 | 106025429 | + | TNKS1BP1 | chr11 | 57067473 | - |
| intron-intron | ENST00000336660 | ENST00000530920 | FHL2 | chr2 | 106025429 | + | TNKS1BP1 | chr11 | 57067473 | - |
| intron-3UTR | ENST00000607522 | ENST00000358252 | FHL2 | chr2 | 106025429 | + | TNKS1BP1 | chr11 | 57067473 | - |
| intron-3UTR | ENST00000607522 | ENST00000532437 | FHL2 | chr2 | 106025429 | + | TNKS1BP1 | chr11 | 57067473 | - |
| intron-intron | ENST00000607522 | ENST00000530920 | FHL2 | chr2 | 106025429 | + | TNKS1BP1 | chr11 | 57067473 | - |
| intron-3UTR | ENST00000409177 | ENST00000358252 | FHL2 | chr2 | 106025429 | + | TNKS1BP1 | chr11 | 57067473 | - |
| intron-3UTR | ENST00000409177 | ENST00000532437 | FHL2 | chr2 | 106025429 | + | TNKS1BP1 | chr11 | 57067473 | - |
| intron-intron | ENST00000409177 | ENST00000530920 | FHL2 | chr2 | 106025429 | + | TNKS1BP1 | chr11 | 57067473 | - |
| intron-3UTR | ENST00000344213 | ENST00000358252 | FHL2 | chr2 | 106025429 | + | TNKS1BP1 | chr11 | 57067473 | - |
| intron-3UTR | ENST00000344213 | ENST00000532437 | FHL2 | chr2 | 106025429 | + | TNKS1BP1 | chr11 | 57067473 | - |
| intron-intron | ENST00000344213 | ENST00000530920 | FHL2 | chr2 | 106025429 | + | TNKS1BP1 | chr11 | 57067473 | - |
| intron-3UTR | ENST00000393353 | ENST00000358252 | FHL2 | chr2 | 106025429 | + | TNKS1BP1 | chr11 | 57067473 | - |
| intron-3UTR | ENST00000393353 | ENST00000532437 | FHL2 | chr2 | 106025429 | + | TNKS1BP1 | chr11 | 57067473 | - |
| intron-intron | ENST00000393353 | ENST00000530920 | FHL2 | chr2 | 106025429 | + | TNKS1BP1 | chr11 | 57067473 | - |
| intron-3UTR | ENST00000322142 | ENST00000358252 | FHL2 | chr2 | 106025429 | + | TNKS1BP1 | chr11 | 57067473 | - |
| intron-3UTR | ENST00000322142 | ENST00000532437 | FHL2 | chr2 | 106025429 | + | TNKS1BP1 | chr11 | 57067473 | - |
| intron-intron | ENST00000322142 | ENST00000530920 | FHL2 | chr2 | 106025429 | + | TNKS1BP1 | chr11 | 57067473 | - |
| intron-3UTR | ENST00000358129 | ENST00000358252 | FHL2 | chr2 | 106025429 | + | TNKS1BP1 | chr11 | 57067473 | - |
| intron-3UTR | ENST00000358129 | ENST00000532437 | FHL2 | chr2 | 106025429 | + | TNKS1BP1 | chr11 | 57067473 | - |
| intron-intron | ENST00000358129 | ENST00000530920 | FHL2 | chr2 | 106025429 | + | TNKS1BP1 | chr11 | 57067473 | - |
| intron-3UTR | ENST00000409807 | ENST00000358252 | FHL2 | chr2 | 106025429 | + | TNKS1BP1 | chr11 | 57067473 | - |
| intron-3UTR | ENST00000409807 | ENST00000532437 | FHL2 | chr2 | 106025429 | + | TNKS1BP1 | chr11 | 57067473 | - |
| intron-intron | ENST00000409807 | ENST00000530920 | FHL2 | chr2 | 106025429 | + | TNKS1BP1 | chr11 | 57067473 | - |
| intron-3UTR | ENST00000408995 | ENST00000358252 | FHL2 | chr2 | 106025429 | + | TNKS1BP1 | chr11 | 57067473 | - |
| intron-3UTR | ENST00000408995 | ENST00000532437 | FHL2 | chr2 | 106025429 | + | TNKS1BP1 | chr11 | 57067473 | - |
| intron-intron | ENST00000408995 | ENST00000530920 | FHL2 | chr2 | 106025429 | + | TNKS1BP1 | chr11 | 57067473 | - |
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FusionProtFeatures for FHL2_TNKS1BP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FHL2 | TNKS1BP1 |