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Fusion gene ID: 13454 |
FusionGeneSummary for FHL1_COX6C |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FHL1_COX6C | Fusion gene ID: 13454 | Hgene | Tgene | Gene symbol | FHL1 | COX6C | Gene ID | 3075 | 1345 |
| Gene name | complement factor H | cytochrome c oxidase subunit 6C | |
| Synonyms | AHUS1|AMBP1|ARMD4|ARMS1|CFHL3|FH|FHL1|HF|HF1|HF2|HUS | - | |
| Cytomap | 1q31.3 | 8q22.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | complement factor HH factor 1 (complement)H factor 2 (complement)adrenomedullin binding proteinage-related maculopathy susceptibility 1beta-1-H-globulinbeta-1Hfactor Hfactor H-like 1 | cytochrome c oxidase subunit 6Ccytochrome c oxidase polypeptide VIccytochrome c oxidase subunit VIc preprotein | |
| Modification date | 20180520 | 20180522 | |
| UniProtAcc | Q13642 | P09669 | |
| Ensembl transtripts involved in fusion gene | ENST00000394155, ENST00000370690, ENST00000535737, ENST00000543669, ENST00000394153, ENST00000345434, ENST00000539015, ENST00000370683, ENST00000370676, ENST00000477080, | ENST00000520468, ENST00000297564, ENST00000520271, ENST00000517682, ENST00000524245, ENST00000522940, ENST00000518171, ENST00000523016, | |
| Fusion gene scores | * DoF score | 4 X 3 X 2=24 | 4 X 3 X 4=48 |
| # samples | 4 | 5 | |
| ** MAII score | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: FHL1 [Title/Abstract] AND COX6C [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | FHL1 | GO:0006956 | complement activation | 24835392 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF825718 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - | ||
| ChiTaRS3.1 | BF827394 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-5UTR | ENST00000394155 | ENST00000520468 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-5UTR | ENST00000394155 | ENST00000297564 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-intron | ENST00000394155 | ENST00000520271 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-intron | ENST00000394155 | ENST00000517682 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-intron | ENST00000394155 | ENST00000524245 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-intron | ENST00000394155 | ENST00000522940 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-5UTR | ENST00000394155 | ENST00000518171 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-5UTR | ENST00000394155 | ENST00000523016 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-5UTR | ENST00000370690 | ENST00000520468 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-5UTR | ENST00000370690 | ENST00000297564 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-intron | ENST00000370690 | ENST00000520271 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-intron | ENST00000370690 | ENST00000517682 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-intron | ENST00000370690 | ENST00000524245 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-intron | ENST00000370690 | ENST00000522940 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-5UTR | ENST00000370690 | ENST00000518171 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-5UTR | ENST00000370690 | ENST00000523016 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-5UTR | ENST00000535737 | ENST00000520468 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-5UTR | ENST00000535737 | ENST00000297564 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-intron | ENST00000535737 | ENST00000520271 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-intron | ENST00000535737 | ENST00000517682 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-intron | ENST00000535737 | ENST00000524245 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-intron | ENST00000535737 | ENST00000522940 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-5UTR | ENST00000535737 | ENST00000518171 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-5UTR | ENST00000535737 | ENST00000523016 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-5UTR | ENST00000543669 | ENST00000520468 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-5UTR | ENST00000543669 | ENST00000297564 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-intron | ENST00000543669 | ENST00000520271 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-intron | ENST00000543669 | ENST00000517682 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-intron | ENST00000543669 | ENST00000524245 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-intron | ENST00000543669 | ENST00000522940 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-5UTR | ENST00000543669 | ENST00000518171 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-5UTR | ENST00000543669 | ENST00000523016 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-5UTR | ENST00000394153 | ENST00000520468 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-5UTR | ENST00000394153 | ENST00000297564 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-intron | ENST00000394153 | ENST00000520271 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-intron | ENST00000394153 | ENST00000517682 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-intron | ENST00000394153 | ENST00000524245 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-intron | ENST00000394153 | ENST00000522940 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-5UTR | ENST00000394153 | ENST00000518171 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-5UTR | ENST00000394153 | ENST00000523016 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-5UTR | ENST00000345434 | ENST00000520468 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-5UTR | ENST00000345434 | ENST00000297564 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-intron | ENST00000345434 | ENST00000520271 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-intron | ENST00000345434 | ENST00000517682 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-intron | ENST00000345434 | ENST00000524245 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-intron | ENST00000345434 | ENST00000522940 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-5UTR | ENST00000345434 | ENST00000518171 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-5UTR | ENST00000345434 | ENST00000523016 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-5UTR | ENST00000539015 | ENST00000520468 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-5UTR | ENST00000539015 | ENST00000297564 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-intron | ENST00000539015 | ENST00000520271 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-intron | ENST00000539015 | ENST00000517682 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-intron | ENST00000539015 | ENST00000524245 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-intron | ENST00000539015 | ENST00000522940 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-5UTR | ENST00000539015 | ENST00000518171 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-5UTR | ENST00000539015 | ENST00000523016 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-5UTR | ENST00000370683 | ENST00000520468 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-5UTR | ENST00000370683 | ENST00000297564 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-intron | ENST00000370683 | ENST00000520271 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-intron | ENST00000370683 | ENST00000517682 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-intron | ENST00000370683 | ENST00000524245 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-intron | ENST00000370683 | ENST00000522940 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-5UTR | ENST00000370683 | ENST00000518171 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| 3UTR-5UTR | ENST00000370683 | ENST00000523016 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| intron-5UTR | ENST00000370676 | ENST00000520468 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| intron-5UTR | ENST00000370676 | ENST00000297564 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| intron-intron | ENST00000370676 | ENST00000520271 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| intron-intron | ENST00000370676 | ENST00000517682 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| intron-intron | ENST00000370676 | ENST00000524245 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| intron-intron | ENST00000370676 | ENST00000522940 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| intron-5UTR | ENST00000370676 | ENST00000518171 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| intron-5UTR | ENST00000370676 | ENST00000523016 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| intron-5UTR | ENST00000477080 | ENST00000520468 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| intron-5UTR | ENST00000477080 | ENST00000297564 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| intron-intron | ENST00000477080 | ENST00000520271 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| intron-intron | ENST00000477080 | ENST00000517682 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| intron-intron | ENST00000477080 | ENST00000524245 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| intron-intron | ENST00000477080 | ENST00000522940 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| intron-5UTR | ENST00000477080 | ENST00000518171 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
| intron-5UTR | ENST00000477080 | ENST00000523016 | FHL1 | chrX | 135292939 | - | COX6C | chr8 | 100905914 | - |
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FusionProtFeatures for FHL1_COX6C |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FHL1 | COX6C |