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Fusion gene ID: 13409 |
FusionGeneSummary for FGFR2_GLB1L2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FGFR2_GLB1L2 | Fusion gene ID: 13409 | Hgene | Tgene | Gene symbol | FGFR2 | GLB1L2 | Gene ID | 2263 | 89944 |
| Gene name | fibroblast growth factor receptor 2 | galactosidase beta 1 like 2 | |
| Synonyms | BBDS|BEK|BFR-1|CD332|CEK3|CFD1|ECT1|JWS|K-SAM|KGFR|TK14|TK25 | MST114|MSTP114 | |
| Cytomap | 10q26.13 | 11q25 | |
| Type of gene | protein-coding | protein-coding | |
| Description | fibroblast growth factor receptor 2BEK fibroblast growth factor receptorbacteria-expressed kinasekeratinocyte growth factor receptorprotein tyrosine kinase, receptor like 14 | beta-galactosidase-1-like protein 2 | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | P21802 | Q8IW92 | |
| Ensembl transtripts involved in fusion gene | ENST00000369061, ENST00000357555, ENST00000358487, ENST00000356226, ENST00000369060, ENST00000369059, ENST00000346997, ENST00000457416, ENST00000351936, ENST00000360144, ENST00000369056, ENST00000490349, ENST00000359354, ENST00000478859, | ENST00000339772, ENST00000535456, ENST00000389881, ENST00000529077, | |
| Fusion gene scores | * DoF score | 18 X 10 X 9=1620 | 1 X 1 X 1=1 |
| # samples | 24 | 1 | |
| ** MAII score | log2(24/1620*10)=-2.75488750216347 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: FGFR2 [Title/Abstract] AND GLB1L2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | FGFR2 | GO:0008284 | positive regulation of cell proliferation | 8663044 |
| Hgene | FGFR2 | GO:0008543 | fibroblast growth factor receptor signaling pathway | 8663044|15629145 |
| Hgene | FGFR2 | GO:0018108 | peptidyl-tyrosine phosphorylation | 15629145|16844695 |
| Hgene | FGFR2 | GO:0046777 | protein autophosphorylation | 15629145 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AI379298 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000369061 | ENST00000339772 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3CDS | ENST00000369061 | ENST00000535456 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3CDS | ENST00000369061 | ENST00000389881 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3UTR | ENST00000369061 | ENST00000529077 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3CDS | ENST00000357555 | ENST00000339772 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3CDS | ENST00000357555 | ENST00000535456 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3CDS | ENST00000357555 | ENST00000389881 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3UTR | ENST00000357555 | ENST00000529077 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3CDS | ENST00000358487 | ENST00000339772 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3CDS | ENST00000358487 | ENST00000535456 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3CDS | ENST00000358487 | ENST00000389881 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3UTR | ENST00000358487 | ENST00000529077 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3CDS | ENST00000356226 | ENST00000339772 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3CDS | ENST00000356226 | ENST00000535456 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3CDS | ENST00000356226 | ENST00000389881 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3UTR | ENST00000356226 | ENST00000529077 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3CDS | ENST00000369060 | ENST00000339772 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3CDS | ENST00000369060 | ENST00000535456 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3CDS | ENST00000369060 | ENST00000389881 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3UTR | ENST00000369060 | ENST00000529077 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3CDS | ENST00000369059 | ENST00000339772 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3CDS | ENST00000369059 | ENST00000535456 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3CDS | ENST00000369059 | ENST00000389881 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3UTR | ENST00000369059 | ENST00000529077 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3CDS | ENST00000346997 | ENST00000339772 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3CDS | ENST00000346997 | ENST00000535456 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3CDS | ENST00000346997 | ENST00000389881 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3UTR | ENST00000346997 | ENST00000529077 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3CDS | ENST00000457416 | ENST00000339772 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3CDS | ENST00000457416 | ENST00000535456 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3CDS | ENST00000457416 | ENST00000389881 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3UTR | ENST00000457416 | ENST00000529077 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3CDS | ENST00000351936 | ENST00000339772 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3CDS | ENST00000351936 | ENST00000535456 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3CDS | ENST00000351936 | ENST00000389881 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3UTR | ENST00000351936 | ENST00000529077 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3CDS | ENST00000360144 | ENST00000339772 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3CDS | ENST00000360144 | ENST00000535456 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3CDS | ENST00000360144 | ENST00000389881 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3UTR | ENST00000360144 | ENST00000529077 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3CDS | ENST00000369056 | ENST00000339772 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3CDS | ENST00000369056 | ENST00000535456 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3CDS | ENST00000369056 | ENST00000389881 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3UTR | ENST00000369056 | ENST00000529077 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3CDS | ENST00000490349 | ENST00000339772 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3CDS | ENST00000490349 | ENST00000535456 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3CDS | ENST00000490349 | ENST00000389881 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3UTR | ENST00000490349 | ENST00000529077 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3CDS | ENST00000359354 | ENST00000339772 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3CDS | ENST00000359354 | ENST00000535456 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3CDS | ENST00000359354 | ENST00000389881 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3UTR | ENST00000359354 | ENST00000529077 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3CDS | ENST00000478859 | ENST00000339772 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3CDS | ENST00000478859 | ENST00000535456 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3CDS | ENST00000478859 | ENST00000389881 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
| intron-3UTR | ENST00000478859 | ENST00000529077 | FGFR2 | chr10 | 123238028 | + | GLB1L2 | chr11 | 134244080 | - |
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FusionProtFeatures for FGFR2_GLB1L2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FGFR2 | GLB1L2 |