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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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RelatedDiseases

Fusion gene ID: 13403

FusionGeneSummary for FGFR2_CCDC6

check button Fusion gene summary
Fusion gene informationFusion gene name: FGFR2_CCDC6
Fusion gene ID: 13403
HgeneTgene
Gene symbol

FGFR2

CCDC6

Gene ID

2263

8030

Gene namefibroblast growth factor receptor 2coiled-coil domain containing 6
SynonymsBBDS|BEK|BFR-1|CD332|CEK3|CFD1|ECT1|JWS|K-SAM|KGFR|TK14|TK25D10S170|H4|PTC|TPC|TST1
Cytomap

10q26.13

10q21.2

Type of geneprotein-codingprotein-coding
Descriptionfibroblast growth factor receptor 2BEK fibroblast growth factor receptorbacteria-expressed kinasekeratinocyte growth factor receptorprotein tyrosine kinase, receptor like 14coiled-coil domain-containing protein 6papillary thyroid carcinoma-encoded protein
Modification date2018052720180522
UniProtAcc

P21802

Q16204

Ensembl transtripts involved in fusion geneENST00000369061, ENST00000357555, 
ENST00000358487, ENST00000356226, 
ENST00000369060, ENST00000369059, 
ENST00000346997, ENST00000457416, 
ENST00000351936, ENST00000360144, 
ENST00000369056, ENST00000490349, 
ENST00000359354, ENST00000478859, 
ENST00000263102, 
Fusion gene scores* DoF score18 X 10 X 9=16208 X 5 X 5=200
# samples 249
** MAII scorelog2(24/1620*10)=-2.75488750216347
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/200*10)=-1.15200309344505
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FGFR2 [Title/Abstract] AND CCDC6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Kinase involved fusion gene, inframe and retained kinase domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFGFR2

GO:0008284

positive regulation of cell proliferation

8663044

HgeneFGFR2

GO:0008543

fibroblast growth factor receptor signaling pathway

8663044|15629145

HgeneFGFR2

GO:0018108

peptidyl-tyrosine phosphorylation

15629145|16844695

HgeneFGFR2

GO:0046777

protein autophosphorylation

15629145


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-D8-A13Z-01AFGFR2chr10

123243212

-CCDC6chr10

61612460

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000369061ENST00000263102FGFR2chr10

123243212

-CCDC6chr10

61612460

-
Frame-shiftENST00000357555ENST00000263102FGFR2chr10

123243212

-CCDC6chr10

61612460

-
Frame-shiftENST00000358487ENST00000263102FGFR2chr10

123243212

-CCDC6chr10

61612460

-
Frame-shiftENST00000356226ENST00000263102FGFR2chr10

123243212

-CCDC6chr10

61612460

-
Frame-shiftENST00000369060ENST00000263102FGFR2chr10

123243212

-CCDC6chr10

61612460

-
Frame-shiftENST00000369059ENST00000263102FGFR2chr10

123243212

-CCDC6chr10

61612460

-
In-frameENST00000346997ENST00000263102FGFR2chr10

123243212

-CCDC6chr10

61612460

-
Frame-shiftENST00000457416ENST00000263102FGFR2chr10

123243212

-CCDC6chr10

61612460

-
Frame-shiftENST00000351936ENST00000263102FGFR2chr10

123243212

-CCDC6chr10

61612460

-
Frame-shiftENST00000360144ENST00000263102FGFR2chr10

123243212

-CCDC6chr10

61612460

-
In-frameENST00000369056ENST00000263102FGFR2chr10

123243212

-CCDC6chr10

61612460

-
intron-3CDSENST00000490349ENST00000263102FGFR2chr10

123243212

-CCDC6chr10

61612460

-
intron-3CDSENST00000359354ENST00000263102FGFR2chr10

123243212

-CCDC6chr10

61612460

-
Frame-shiftENST00000478859ENST00000263102FGFR2chr10

123243212

-CCDC6chr10

61612460

-

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FusionProtFeatures for FGFR2_CCDC6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FGFR2

P21802

CCDC6

Q16204


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFGFR2chr10:123243212chr10:61612460ENST00000346997-1617154_247765820DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243212chr10:61612460ENST00000346997-1617256_358765820DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243212chr10:61612460ENST00000346997-161725_125765820DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243212chr10:61612460ENST00000351936-1718154_247765786DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243212chr10:61612460ENST00000351936-1718256_358765786DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243212chr10:61612460ENST00000351936-171825_125765786DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243212chr10:61612460ENST00000356226-1516154_247650705DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243212chr10:61612460ENST00000356226-1516256_358650705DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243212chr10:61612460ENST00000356226-151625_125650705DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243212chr10:61612460ENST00000357555-1617154_247678708DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243212chr10:61612460ENST00000357555-1617256_358678708DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243212chr10:61612460ENST00000357555-161725_125678708DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243212chr10:61612460ENST00000358487-1718154_247767822DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243212chr10:61612460ENST00000358487-1718256_358767822DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243212chr10:61612460ENST00000358487-171825_125767822DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243212chr10:61612460ENST00000358487-1718481_770767822DomainProtein kinase
HgeneFGFR2chr10:123243212chr10:61612460ENST00000360144-1617154_247679681DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243212chr10:61612460ENST00000360144-1617256_358679681DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243212chr10:61612460ENST00000360144-161725_125679681DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369056-1617154_247768770DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369056-1617256_358768770DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369056-161725_125768770DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369056-1617481_770768770DomainProtein kinase
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369060-1516154_247651706DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369060-1516256_358651706DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369060-151625_125651706DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369061-1415154_247655710DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369061-1415256_358655710DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369061-141525_125655710DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243212chr10:61612460ENST00000457416-1718154_247768823DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243212chr10:61612460ENST00000457416-1718256_358768823DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243212chr10:61612460ENST00000457416-171825_125768823DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243212chr10:61612460ENST00000457416-1718481_770768823DomainProtein kinase
HgeneFGFR2chr10:123243212chr10:61612460ENST00000346997-1617487_495765820Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr10:61612460ENST00000346997-1617565_567765820Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr10:61612460ENST00000351936-1718487_495765786Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr10:61612460ENST00000351936-1718565_567765786Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr10:61612460ENST00000356226-1516487_495650705Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr10:61612460ENST00000356226-1516565_567650705Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr10:61612460ENST00000357555-1617487_495678708Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr10:61612460ENST00000357555-1617565_567678708Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr10:61612460ENST00000358487-1718487_495767822Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr10:61612460ENST00000358487-1718565_567767822Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr10:61612460ENST00000360144-1617487_495679681Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr10:61612460ENST00000360144-1617565_567679681Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369056-1617487_495768770Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369056-1617565_567768770Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369060-1516487_495651706Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369060-1516565_567651706Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369061-1415487_495655710Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369061-1415565_567655710Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr10:61612460ENST00000457416-1718487_495768823Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr10:61612460ENST00000457416-1718565_567768823Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr10:61612460ENST00000346997-1617161_178765820RegionNote=Heparin-binding
HgeneFGFR2chr10:123243212chr10:61612460ENST00000351936-1718161_178765786RegionNote=Heparin-binding
HgeneFGFR2chr10:123243212chr10:61612460ENST00000356226-1516161_178650705RegionNote=Heparin-binding
HgeneFGFR2chr10:123243212chr10:61612460ENST00000357555-1617161_178678708RegionNote=Heparin-binding
HgeneFGFR2chr10:123243212chr10:61612460ENST00000358487-1718161_178767822RegionNote=Heparin-binding
HgeneFGFR2chr10:123243212chr10:61612460ENST00000360144-1617161_178679681RegionNote=Heparin-binding
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369056-1617161_178768770RegionNote=Heparin-binding
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369060-1516161_178651706RegionNote=Heparin-binding
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369061-1415161_178655710RegionNote=Heparin-binding
HgeneFGFR2chr10:123243212chr10:61612460ENST00000457416-1718161_178768823RegionNote=Heparin-binding
HgeneFGFR2chr10:123243212chr10:61612460ENST00000346997-161722_377765820Topological domainExtracellular
HgeneFGFR2chr10:123243212chr10:61612460ENST00000351936-171822_377765786Topological domainExtracellular
HgeneFGFR2chr10:123243212chr10:61612460ENST00000356226-151622_377650705Topological domainExtracellular
HgeneFGFR2chr10:123243212chr10:61612460ENST00000357555-161722_377678708Topological domainExtracellular
HgeneFGFR2chr10:123243212chr10:61612460ENST00000358487-171822_377767822Topological domainExtracellular
HgeneFGFR2chr10:123243212chr10:61612460ENST00000360144-161722_377679681Topological domainExtracellular
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369056-161722_377768770Topological domainExtracellular
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369060-151622_377651706Topological domainExtracellular
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369061-141522_377655710Topological domainExtracellular
HgeneFGFR2chr10:123243212chr10:61612460ENST00000457416-171822_377768823Topological domainExtracellular
HgeneFGFR2chr10:123243212chr10:61612460ENST00000346997-1617378_398765820TransmembraneHelical
HgeneFGFR2chr10:123243212chr10:61612460ENST00000351936-1718378_398765786TransmembraneHelical
HgeneFGFR2chr10:123243212chr10:61612460ENST00000356226-1516378_398650705TransmembraneHelical
HgeneFGFR2chr10:123243212chr10:61612460ENST00000357555-1617378_398678708TransmembraneHelical
HgeneFGFR2chr10:123243212chr10:61612460ENST00000358487-1718378_398767822TransmembraneHelical
HgeneFGFR2chr10:123243212chr10:61612460ENST00000360144-1617378_398679681TransmembraneHelical
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369056-1617378_398768770TransmembraneHelical
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369060-1516378_398651706TransmembraneHelical
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369061-1415378_398655710TransmembraneHelical
HgeneFGFR2chr10:123243212chr10:61612460ENST00000457416-1718378_398768823TransmembraneHelical
TgeneCCDC6chr10:123243212chr10:61612460ENST00000263102-09253_332101475Coiled coilOntology_term=ECO:0000255
TgeneCCDC6chr10:123243212chr10:61612460ENST00000263102-09440_448101475Compositional biasNote=Poly-Pro
TgeneCCDC6chr10:123243212chr10:61612460ENST00000263102-09442_451101475MotifSH3-binding
TgeneCCDC6chr10:123243212chr10:61612460ENST00000263102-09106_235101475RegionNote=5 X 29 AA tandem repeats
TgeneCCDC6chr10:123243212chr10:61612460ENST00000263102-09106_134101475RepeatNote=1
TgeneCCDC6chr10:123243212chr10:61612460ENST00000263102-09135_163101475RepeatNote=2
TgeneCCDC6chr10:123243212chr10:61612460ENST00000263102-09164_192101475RepeatNote=3
TgeneCCDC6chr10:123243212chr10:61612460ENST00000263102-09193_206101475RepeatNote=4%3B approximate
TgeneCCDC6chr10:123243212chr10:61612460ENST00000263102-09207_235101475RepeatNote=5

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFGFR2chr10:123243212chr10:61612460ENST00000346997-1617481_770765820DomainProtein kinase
HgeneFGFR2chr10:123243212chr10:61612460ENST00000351936-1718481_770765786DomainProtein kinase
HgeneFGFR2chr10:123243212chr10:61612460ENST00000356226-1516481_770650705DomainProtein kinase
HgeneFGFR2chr10:123243212chr10:61612460ENST00000357555-1617481_770678708DomainProtein kinase
HgeneFGFR2chr10:123243212chr10:61612460ENST00000359354-17154_247-163255DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243212chr10:61612460ENST00000359354-17256_358-163255DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243212chr10:61612460ENST00000359354-1725_125-163255DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243212chr10:61612460ENST00000359354-17481_770-163255DomainProtein kinase
HgeneFGFR2chr10:123243212chr10:61612460ENST00000360144-1617481_770679681DomainProtein kinase
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369060-1516481_770651706DomainProtein kinase
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369061-1415481_770655710DomainProtein kinase
HgeneFGFR2chr10:123243212chr10:61612460ENST00000359354-17487_495-163255Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr10:61612460ENST00000359354-17565_567-163255Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr10:61612460ENST00000359354-17161_178-163255RegionNote=Heparin-binding
HgeneFGFR2chr10:123243212chr10:61612460ENST00000346997-1617399_821765820Topological domainCytoplasmic
HgeneFGFR2chr10:123243212chr10:61612460ENST00000351936-1718399_821765786Topological domainCytoplasmic
HgeneFGFR2chr10:123243212chr10:61612460ENST00000356226-1516399_821650705Topological domainCytoplasmic
HgeneFGFR2chr10:123243212chr10:61612460ENST00000357555-1617399_821678708Topological domainCytoplasmic
HgeneFGFR2chr10:123243212chr10:61612460ENST00000358487-1718399_821767822Topological domainCytoplasmic
HgeneFGFR2chr10:123243212chr10:61612460ENST00000359354-1722_377-163255Topological domainExtracellular
HgeneFGFR2chr10:123243212chr10:61612460ENST00000359354-17399_821-163255Topological domainCytoplasmic
HgeneFGFR2chr10:123243212chr10:61612460ENST00000360144-1617399_821679681Topological domainCytoplasmic
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369056-1617399_821768770Topological domainCytoplasmic
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369060-1516399_821651706Topological domainCytoplasmic
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369061-1415399_821655710Topological domainCytoplasmic
HgeneFGFR2chr10:123243212chr10:61612460ENST00000457416-1718399_821768823Topological domainCytoplasmic
HgeneFGFR2chr10:123243212chr10:61612460ENST00000359354-17378_398-163255TransmembraneHelical
TgeneCCDC6chr10:123243212chr10:61612460ENST00000263102-0953_237101475Coiled coilOntology_term=ECO:0000255
TgeneCCDC6chr10:123243212chr10:61612460ENST00000263102-0917_20101475Compositional biasNote=Poly-Ser
TgeneCCDC6chr10:123243212chr10:61612460ENST00000263102-0932_44101475Compositional biasNote=Poly-Gly


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FusionGeneSequence for FGFR2_CCDC6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_FGFR2_ENST00000369061_chr10_123243212_-_CCDC6_ENST00000263102_chr10_61612460_-_1029aa
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGE
YLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVAPGREKEITASPDYLEIAIYC
IGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDP
KWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYV
IVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDIN
NIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHA
VPSQRPTFKQLVEDLDRILTLTTNEQARAEQEEEFISNTLFKKIQALQKEKETLAVNYEKEEEFLTNELSRKLMQLQHEKAELEQHLEQE
QEFQVNKLMKKIKKLENDTISKQLTLEQLRREKIDLENTLEQEQEALVNRLWKRMDKLEAEKRILQEKLDQPVSAPPSPRDISMEIDSPE
NMMRHIRFLKNEVERLKKQLRAAQLQHSEKMAQYLEEERHMREENLRLQRKLQREMERREALCRQLSESESSLEMDDERYFNEMSAQGLR
PRTVSSPIPYTPSPSSSRPISPGLSYASHTVGFTPPTSLTRAGMSYYNSPGLHVQHMGTSHGITRPSPRRSNSPDKFKRPTPPPSPNTQT

>In-frame_FGFR2_ENST00000346997_chr10_123243212_-_CCDC6_ENST00000263102_chr10_61612460_-_1139aa
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGE
YLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVV
GGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL
PAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVSAESSSSMNSNTPLVRITTRLS
STADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIG
KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNV
LVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRM
DKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEQARAEQEEEFISNTLFKKIQALQKEKETLAVNYEKEEEFLTNELS
RKLMQLQHEKAELEQHLEQEQEFQVNKLMKKIKKLENDTISKQLTLEQLRREKIDLENTLEQEQEALVNRLWKRMDKLEAEKRILQEKLD
QPVSAPPSPRDISMEIDSPENMMRHIRFLKNEVERLKKQLRAAQLQHSEKMAQYLEEERHMREENLRLQRKLQREMERREALCRQLSESE
SSLEMDDERYFNEMSAQGLRPRTVSSPIPYTPSPSSSRPISPGLSYASHTVGFTPPTSLTRAGMSYYNSPGLHVQHMGTSHGITRPSPRR

>In-frame_FGFR2_ENST00000369056_chr10_123243212_-_CCDC6_ENST00000263102_chr10_61612460_-_1142aa
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGE
YLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVV
GGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPK
QQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITT
RLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMK
MIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA
RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEG
HRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEQARAEQEEEFISNTLFKKIQALQKEKETLAVNYEKEEEFLTN
ELSRKLMQLQHEKAELEQHLEQEQEFQVNKLMKKIKKLENDTISKQLTLEQLRREKIDLENTLEQEQEALVNRLWKRMDKLEAEKRILQE
KLDQPVSAPPSPRDISMEIDSPENMMRHIRFLKNEVERLKKQLRAAQLQHSEKMAQYLEEERHMREENLRLQRKLQREMERREALCRQLS
ESESSLEMDDERYFNEMSAQGLRPRTVSSPIPYTPSPSSSRPISPGLSYASHTVGFTPPTSLTRAGMSYYNSPGLHVQHMGTSHGITRPS


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_FGFR2_ENST00000369061_chr10_123243212_-_CCDC6_ENST00000263102_chr10_61612460_-_3087nt
ATGGTCAGCTGGGGTCGTTTCATCTGCCTGGTCGTGGTCACCATGGCAACCTTGTCCCTGGCCCGGCCCTCCTTCAGTTTAGTTGAGGAT
ACCACATTAGAGCCAGAAGAGCCACCAACCAAATACCAAATCTCTCAACCAGAAGTGTACGTGGCTGCGCCAGGGGAGTCGCTAGAGGTG
CGCTGCCTGTTGAAAGATGCCGCCGTGATCAGTTGGACTAAGGATGGGGTGCACTTGGGGCCCAACAATAGGACAGTGCTTATTGGGGAG
TACTTGCAGATAAAGGGCGCCACGCCTAGAGACTCCGGCCTCTATGCTTGTACTGCCAGTAGGACTGTAGACAGTGAAACTTGGTACTTC
ATGGTGAATGTCACAGATGCCATCTCATCCGGAGATGATGAGGATGACACCGATGGTGCGGAAGATTTTGTCAGTGAGAACAGTAACAAC
AAGAGAGCACCATACTGGACCAACACAGAAAAGATGGAAAAGCGGCTCCATGCTGTGCCTGCGGCCAACACTGTCAAGTTTCGCTGCCCA
GCCGGGGGGAACCCAATGCCAACCATGCGGTGGCTGAAAAACGGGAAGGAGTTTAAGCAGGAGCATCGCATTGGAGGCTACAAGGTACGA
AACCAGCACTGGAGCCTCATTATGGAAAGTGTGGTCCCATCTGACAAGGGAAATTATACCTGTGTAGTGGAGAATGAATACGGGTCCATC
AATCACACGTACCACCTGGATGTTGTGGCGCCTGGAAGAGAAAAGGAGATTACAGCTTCCCCAGACTACCTGGAGATAGCCATTTACTGC
ATAGGGGTCTTCTTAATCGCCTGTATGGTGGTAACAGTCATCCTGTGCCGAATGAAGAACACGACCAAGAAGCCAGACTTCAGCAGCCAG
CCGGCTGTGCACAAGCTGACCAAACGTATCCCCCTGCGGAGACAGGTAACAGTTTCGGCTGAGTCCAGCTCCTCCATGAACTCCAACACC
CCGCTGGTGAGGATAACAACACGCCTCTCTTCAACGGCAGACACCCCCATGCTGGCAGGGGTCTCCGAGTATGAACTTCCAGAGGACCCA
AAATGGGAGTTTCCAAGAGATAAGCTGACACTGGGCAAGCCCCTGGGAGAAGGTTGCTTTGGGCAAGTGGTCATGGCGGAAGCAGTGGGA
ATTGACAAAGACAAGCCCAAGGAGGCGGTCACCGTGGCCGTGAAGATGTTGAAAGATGATGCCACAGAGAAAGACCTTTCTGATCTGGTG
TCAGAGATGGAGATGATGAAGATGATTGGGAAACACAAGAATATCATAAATCTTCTTGGAGCCTGCACACAGGATGGGCCTCTCTATGTC
ATAGTTGAGTATGCCTCTAAAGGCAACCTCCGAGAATACCTCCGAGCCCGGAGGCCACCCGGGATGGAGTACTCCTATGACATTAACCGT
GTTCCTGAGGAGCAGATGACCTTCAAGGACTTGGTGTCATGCACCTACCAGCTGGCCAGAGGCATGGAGTACTTGGCTTCCCAAAAATGT
ATTCATCGAGATTTAGCAGCCAGAAATGTTTTGGTAACAGAAAACAATGTGATGAAAATAGCAGACTTTGGACTCGCCAGAGATATCAAC
AATATAGACTATTACAAAAAGACCACCAATGGGCGGCTTCCAGTCAAGTGGATGGCTCCAGAAGCCCTGTTTGATAGAGTATACACTCAT
CAGAGTGATGTCTGGTCCTTCGGGGTGTTAATGTGGGAGATCTTCACTTTAGGGGGCTCGCCCTACCCAGGGATTCCCGTGGAGGAACTT
TTTAAGCTGCTGAAGGAAGGACACAGAATGGATAAGCCAGCCAACTGCACCAACGAACTGTACATGATGATGAGGGACTGTTGGCATGCA
GTGCCCTCCCAGAGACCAACGTTCAAGCAGTTGGTAGAAGACTTGGATCGAATTCTCACTCTCACAACCAATGAGCAAGCCAGGGCTGAG
CAGGAAGAAGAATTCATTAGTAACACTTTATTCAAGAAAATTCAGGCTTTGCAGAAGGAGAAAGAAACCCTTGCTGTAAATTATGAGAAA
GAAGAAGAATTCCTCACTAATGAGCTCTCCAGAAAATTGATGCAGTTGCAGCATGAGAAAGCCGAACTAGAACAGCATCTTGAACAAGAG
CAGGAATTTCAGGTCAACAAACTGATGAAGAAAATTAAAAAACTGGAGAATGACACCATTTCTAAGCAACTTACATTAGAACAGTTGAGA
CGGGAGAAGATTGACCTTGAAAATACATTGGAACAAGAACAAGAAGCACTAGTTAATCGCCTCTGGAAAAGGATGGATAAGCTTGAAGCT
GAAAAGCGAATCCTGCAGGAAAAATTAGACCAGCCCGTCTCTGCTCCACCATCGCCTAGAGATATCTCCATGGAGATTGATTCTCCAGAA
AATATGATGCGTCACATCAGGTTTTTAAAGAATGAAGTGGAACGGCTGAAGAAGCAACTGAGAGCTGCTCAGTTACAGCATTCAGAGAAA
ATGGCACAGTATCTGGAGGAGGAACGTCACATGAGAGAAGAGAACTTGAGGCTCCAGAGGAAGCTGCAGAGGGAGATGGAGAGAAGAGAA
GCCCTCTGTCGACAGCTCTCCGAGAGTGAGTCCAGCTTAGAAATGGACGACGAAAGGTATTTTAATGAGATGTCTGCACAAGGATTAAGA
CCTCGCACTGTGTCCAGCCCGATCCCTTACACACCTTCTCCGAGTTCAAGCAGGCCTATATCACCTGGTCTATCATATGCAAGTCACACG
GTTGGTTTCACGCCACCAACTTCACTGACTAGAGCTGGAATGTCTTATTACAATTCCCCGGGTCTTCACGTGCAGCACATGGGAACATCC
CATGGTATCACAAGGCCTTCACCACGGAGAAGCAACAGTCCTGACAAATTCAAACGGCCCACGCCGCCTCCATCTCCCAACACACAGACC
CCAGTCCAGCCACCTCCGCCTCCACCTCCGCCACCCATGCAGCCCACGGTCCCCTCAGCAGCCACCTCGCAGCCTACTCCTTCGCAACAT

>In-frame_FGFR2_ENST00000346997_chr10_123243212_-_CCDC6_ENST00000263102_chr10_61612460_-_3417nt
ATGGTCAGCTGGGGTCGTTTCATCTGCCTGGTCGTGGTCACCATGGCAACCTTGTCCCTGGCCCGGCCCTCCTTCAGTTTAGTTGAGGAT
ACCACATTAGAGCCAGAAGAGCCACCAACCAAATACCAAATCTCTCAACCAGAAGTGTACGTGGCTGCGCCAGGGGAGTCGCTAGAGGTG
CGCTGCCTGTTGAAAGATGCCGCCGTGATCAGTTGGACTAAGGATGGGGTGCACTTGGGGCCCAACAATAGGACAGTGCTTATTGGGGAG
TACTTGCAGATAAAGGGCGCCACGCCTAGAGACTCCGGCCTCTATGCTTGTACTGCCAGTAGGACTGTAGACAGTGAAACTTGGTACTTC
ATGGTGAATGTCACAGATGCCATCTCATCCGGAGATGATGAGGATGACACCGATGGTGCGGAAGATTTTGTCAGTGAGAACAGTAACAAC
AAGAGAGCACCATACTGGACCAACACAGAAAAGATGGAAAAGCGGCTCCATGCTGTGCCTGCGGCCAACACTGTCAAGTTTCGCTGCCCA
GCCGGGGGGAACCCAATGCCAACCATGCGGTGGCTGAAAAACGGGAAGGAGTTTAAGCAGGAGCATCGCATTGGAGGCTACAAGGTACGA
AACCAGCACTGGAGCCTCATTATGGAAAGTGTGGTCCCATCTGACAAGGGAAATTATACCTGTGTAGTGGAGAATGAATACGGGTCCATC
AATCACACGTACCACCTGGATGTTGTGGAGCGATCGCCTCACCGGCCCATCCTCCAAGCCGGACTGCCGGCAAATGCCTCCACAGTGGTC
GGAGGAGACGTAGAGTTTGTCTGCAAGGTTTACAGTGATGCCCAGCCCCACATCCAGTGGATCAAGCACGTGGAAAAGAACGGCAGTAAA
TACGGGCCCGACGGGCTGCCCTACCTCAAGGTTCTCAAGGCCGCCGGTGTTAACACCACGGACAAAGAGATTGAGGTTCTCTATATTCGG
AATGTAACTTTTGAGGACGCTGGGGAATATACGTGCTTGGCGGGTAATTCTATTGGGATATCCTTTCACTCTGCATGGTTGACAGTTCTG
CCAGCGCCTGGAAGAGAAAAGGAGATTACAGCTTCCCCAGACTACCTGGAGATAGCCATTTACTGCATAGGGGTCTTCTTAATCGCCTGT
ATGGTGGTAACAGTCATCCTGTGCCGAATGAAGAACACGACCAAGAAGCCAGACTTCAGCAGCCAGCCGGCTGTGCACAAGCTGACCAAA
CGTATCCCCCTGCGGAGACAGGTTTCGGCTGAGTCCAGCTCCTCCATGAACTCCAACACCCCGCTGGTGAGGATAACAACACGCCTCTCT
TCAACGGCAGACACCCCCATGCTGGCAGGGGTCTCCGAGTATGAACTTCCAGAGGACCCAAAATGGGAGTTTCCAAGAGATAAGCTGACA
CTGGGCAAGCCCCTGGGAGAAGGTTGCTTTGGGCAAGTGGTCATGGCGGAAGCAGTGGGAATTGACAAAGACAAGCCCAAGGAGGCGGTC
ACCGTGGCCGTGAAGATGTTGAAAGATGATGCCACAGAGAAAGACCTTTCTGATCTGGTGTCAGAGATGGAGATGATGAAGATGATTGGG
AAACACAAGAATATCATAAATCTTCTTGGAGCCTGCACACAGGATGGGCCTCTCTATGTCATAGTTGAGTATGCCTCTAAAGGCAACCTC
CGAGAATACCTCCGAGCCCGGAGGCCACCCGGGATGGAGTACTCCTATGACATTAACCGTGTTCCTGAGGAGCAGATGACCTTCAAGGAC
TTGGTGTCATGCACCTACCAGCTGGCCAGAGGCATGGAGTACTTGGCTTCCCAAAAATGTATTCATCGAGATTTAGCAGCCAGAAATGTT
TTGGTAACAGAAAACAATGTGATGAAAATAGCAGACTTTGGACTCGCCAGAGATATCAACAATATAGACTATTACAAAAAGACCACCAAT
GGGCGGCTTCCAGTCAAGTGGATGGCTCCAGAAGCCCTGTTTGATAGAGTATACACTCATCAGAGTGATGTCTGGTCCTTCGGGGTGTTA
ATGTGGGAGATCTTCACTTTAGGGGGCTCGCCCTACCCAGGGATTCCCGTGGAGGAACTTTTTAAGCTGCTGAAGGAAGGACACAGAATG
GATAAGCCAGCCAACTGCACCAACGAACTGTACATGATGATGAGGGACTGTTGGCATGCAGTGCCCTCCCAGAGACCAACGTTCAAGCAG
TTGGTAGAAGACTTGGATCGAATTCTCACTCTCACAACCAATGAGCAAGCCAGGGCTGAGCAGGAAGAAGAATTCATTAGTAACACTTTA
TTCAAGAAAATTCAGGCTTTGCAGAAGGAGAAAGAAACCCTTGCTGTAAATTATGAGAAAGAAGAAGAATTCCTCACTAATGAGCTCTCC
AGAAAATTGATGCAGTTGCAGCATGAGAAAGCCGAACTAGAACAGCATCTTGAACAAGAGCAGGAATTTCAGGTCAACAAACTGATGAAG
AAAATTAAAAAACTGGAGAATGACACCATTTCTAAGCAACTTACATTAGAACAGTTGAGACGGGAGAAGATTGACCTTGAAAATACATTG
GAACAAGAACAAGAAGCACTAGTTAATCGCCTCTGGAAAAGGATGGATAAGCTTGAAGCTGAAAAGCGAATCCTGCAGGAAAAATTAGAC
CAGCCCGTCTCTGCTCCACCATCGCCTAGAGATATCTCCATGGAGATTGATTCTCCAGAAAATATGATGCGTCACATCAGGTTTTTAAAG
AATGAAGTGGAACGGCTGAAGAAGCAACTGAGAGCTGCTCAGTTACAGCATTCAGAGAAAATGGCACAGTATCTGGAGGAGGAACGTCAC
ATGAGAGAAGAGAACTTGAGGCTCCAGAGGAAGCTGCAGAGGGAGATGGAGAGAAGAGAAGCCCTCTGTCGACAGCTCTCCGAGAGTGAG
TCCAGCTTAGAAATGGACGACGAAAGGTATTTTAATGAGATGTCTGCACAAGGATTAAGACCTCGCACTGTGTCCAGCCCGATCCCTTAC
ACACCTTCTCCGAGTTCAAGCAGGCCTATATCACCTGGTCTATCATATGCAAGTCACACGGTTGGTTTCACGCCACCAACTTCACTGACT
AGAGCTGGAATGTCTTATTACAATTCCCCGGGTCTTCACGTGCAGCACATGGGAACATCCCATGGTATCACAAGGCCTTCACCACGGAGA
AGCAACAGTCCTGACAAATTCAAACGGCCCACGCCGCCTCCATCTCCCAACACACAGACCCCAGTCCAGCCACCTCCGCCTCCACCTCCG

>In-frame_FGFR2_ENST00000369056_chr10_123243212_-_CCDC6_ENST00000263102_chr10_61612460_-_3426nt
ATGGTCAGCTGGGGTCGTTTCATCTGCCTGGTCGTGGTCACCATGGCAACCTTGTCCCTGGCCCGGCCCTCCTTCAGTTTAGTTGAGGAT
ACCACATTAGAGCCAGAAGAGCCACCAACCAAATACCAAATCTCTCAACCAGAAGTGTACGTGGCTGCGCCAGGGGAGTCGCTAGAGGTG
CGCTGCCTGTTGAAAGATGCCGCCGTGATCAGTTGGACTAAGGATGGGGTGCACTTGGGGCCCAACAATAGGACAGTGCTTATTGGGGAG
TACTTGCAGATAAAGGGCGCCACGCCTAGAGACTCCGGCCTCTATGCTTGTACTGCCAGTAGGACTGTAGACAGTGAAACTTGGTACTTC
ATGGTGAATGTCACAGATGCCATCTCATCCGGAGATGATGAGGATGACACCGATGGTGCGGAAGATTTTGTCAGTGAGAACAGTAACAAC
AAGAGAGCACCATACTGGACCAACACAGAAAAGATGGAAAAGCGGCTCCATGCTGTGCCTGCGGCCAACACTGTCAAGTTTCGCTGCCCA
GCCGGGGGGAACCCAATGCCAACCATGCGGTGGCTGAAAAACGGGAAGGAGTTTAAGCAGGAGCATCGCATTGGAGGCTACAAGGTACGA
AACCAGCACTGGAGCCTCATTATGGAAAGTGTGGTCCCATCTGACAAGGGAAATTATACCTGTGTAGTGGAGAATGAATACGGGTCCATC
AATCACACGTACCACCTGGATGTTGTGGAGCGATCGCCTCACCGGCCCATCCTCCAAGCCGGACTGCCGGCAAATGCCTCCACAGTGGTC
GGAGGAGACGTAGAGTTTGTCTGCAAGGTTTACAGTGATGCCCAGCCCCACATCCAGTGGATCAAGCACGTGGAAAAGAACGGCAGTAAA
TACGGGCCCGACGGGCTGCCCTACCTCAAGGTTCTCAAGCACTCGGGGATAAATAGTTCCAATGCAGAAGTGCTGGCTCTGTTCAATGTG
ACCGAGGCGGATGCTGGGGAATATATATGTAAGGTCTCCAATTATATAGGGCAGGCCAACCAGTCTGCCTGGCTCACTGTCCTGCCAAAA
CAGCAAGCGCCTGGAAGAGAAAAGGAGATTACAGCTTCCCCAGACTACCTGGAGATAGCCATTTACTGCATAGGGGTCTTCTTAATCGCC
TGTATGGTGGTAACAGTCATCCTGTGCCGAATGAAGAACACGACCAAGAAGCCAGACTTCAGCAGCCAGCCGGCTGTGCACAAGCTGACC
AAACGTATCCCCCTGCGGAGACAGGTAACAGTTTCGGCTGAGTCCAGCTCCTCCATGAACTCCAACACCCCGCTGGTGAGGATAACAACA
CGCCTCTCTTCAACGGCAGACACCCCCATGCTGGCAGGGGTCTCCGAGTATGAACTTCCAGAGGACCCAAAATGGGAGTTTCCAAGAGAT
AAGCTGACACTGGGCAAGCCCCTGGGAGAAGGTTGCTTTGGGCAAGTGGTCATGGCGGAAGCAGTGGGAATTGACAAAGACAAGCCCAAG
GAGGCGGTCACCGTGGCCGTGAAGATGTTGAAAGATGATGCCACAGAGAAAGACCTTTCTGATCTGGTGTCAGAGATGGAGATGATGAAG
ATGATTGGGAAACACAAGAATATCATAAATCTTCTTGGAGCCTGCACACAGGATGGGCCTCTCTATGTCATAGTTGAGTATGCCTCTAAA
GGCAACCTCCGAGAATACCTCCGAGCCCGGAGGCCACCCGGGATGGAGTACTCCTATGACATTAACCGTGTTCCTGAGGAGCAGATGACC
TTCAAGGACTTGGTGTCATGCACCTACCAGCTGGCCAGAGGCATGGAGTACTTGGCTTCCCAAAAATGTATTCATCGAGATTTAGCAGCC
AGAAATGTTTTGGTAACAGAAAACAATGTGATGAAAATAGCAGACTTTGGACTCGCCAGAGATATCAACAATATAGACTATTACAAAAAG
ACCACCAATGGGCGGCTTCCAGTCAAGTGGATGGCTCCAGAAGCCCTGTTTGATAGAGTATACACTCATCAGAGTGATGTCTGGTCCTTC
GGGGTGTTAATGTGGGAGATCTTCACTTTAGGGGGCTCGCCCTACCCAGGGATTCCCGTGGAGGAACTTTTTAAGCTGCTGAAGGAAGGA
CACAGAATGGATAAGCCAGCCAACTGCACCAACGAACTGTACATGATGATGAGGGACTGTTGGCATGCAGTGCCCTCCCAGAGACCAACG
TTCAAGCAGTTGGTAGAAGACTTGGATCGAATTCTCACTCTCACAACCAATGAGCAAGCCAGGGCTGAGCAGGAAGAAGAATTCATTAGT
AACACTTTATTCAAGAAAATTCAGGCTTTGCAGAAGGAGAAAGAAACCCTTGCTGTAAATTATGAGAAAGAAGAAGAATTCCTCACTAAT
GAGCTCTCCAGAAAATTGATGCAGTTGCAGCATGAGAAAGCCGAACTAGAACAGCATCTTGAACAAGAGCAGGAATTTCAGGTCAACAAA
CTGATGAAGAAAATTAAAAAACTGGAGAATGACACCATTTCTAAGCAACTTACATTAGAACAGTTGAGACGGGAGAAGATTGACCTTGAA
AATACATTGGAACAAGAACAAGAAGCACTAGTTAATCGCCTCTGGAAAAGGATGGATAAGCTTGAAGCTGAAAAGCGAATCCTGCAGGAA
AAATTAGACCAGCCCGTCTCTGCTCCACCATCGCCTAGAGATATCTCCATGGAGATTGATTCTCCAGAAAATATGATGCGTCACATCAGG
TTTTTAAAGAATGAAGTGGAACGGCTGAAGAAGCAACTGAGAGCTGCTCAGTTACAGCATTCAGAGAAAATGGCACAGTATCTGGAGGAG
GAACGTCACATGAGAGAAGAGAACTTGAGGCTCCAGAGGAAGCTGCAGAGGGAGATGGAGAGAAGAGAAGCCCTCTGTCGACAGCTCTCC
GAGAGTGAGTCCAGCTTAGAAATGGACGACGAAAGGTATTTTAATGAGATGTCTGCACAAGGATTAAGACCTCGCACTGTGTCCAGCCCG
ATCCCTTACACACCTTCTCCGAGTTCAAGCAGGCCTATATCACCTGGTCTATCATATGCAAGTCACACGGTTGGTTTCACGCCACCAACT
TCACTGACTAGAGCTGGAATGTCTTATTACAATTCCCCGGGTCTTCACGTGCAGCACATGGGAACATCCCATGGTATCACAAGGCCTTCA
CCACGGAGAAGCAACAGTCCTGACAAATTCAAACGGCCCACGCCGCCTCCATCTCCCAACACACAGACCCCAGTCCAGCCACCTCCGCCT
CCACCTCCGCCACCCATGCAGCCCACGGTCCCCTCAGCAGCCACCTCGCAGCCTACTCCTTCGCAACATTCGGCGCACCCCTCCTCCCAG


* Fusion transcript sequences (Full-length transcript).
>In-frame_FGFR2_ENST00000369061_chr10_123243212_-_CCDC6_ENST00000263102_chr10_61612460_-_7391nt
TGACTGCAGCAGCAGCGGCAGCGCCTCGGTTCCTGAGCCCACCGCAGGCTGAAGGCATTGCGCGTAGTCCATGCCCGTAGAGGAAGTGTG
CAGATGGGATTAACGTCCACATGGAGATATGGAAGAGGACCGGGGATTGGTACCGTAACCATGGTCAGCTGGGGTCGTTTCATCTGCCTG
GTCGTGGTCACCATGGCAACCTTGTCCCTGGCCCGGCCCTCCTTCAGTTTAGTTGAGGATACCACATTAGAGCCAGAAGAGCCACCAACC
AAATACCAAATCTCTCAACCAGAAGTGTACGTGGCTGCGCCAGGGGAGTCGCTAGAGGTGCGCTGCCTGTTGAAAGATGCCGCCGTGATC
AGTTGGACTAAGGATGGGGTGCACTTGGGGCCCAACAATAGGACAGTGCTTATTGGGGAGTACTTGCAGATAAAGGGCGCCACGCCTAGA
GACTCCGGCCTCTATGCTTGTACTGCCAGTAGGACTGTAGACAGTGAAACTTGGTACTTCATGGTGAATGTCACAGATGCCATCTCATCC
GGAGATGATGAGGATGACACCGATGGTGCGGAAGATTTTGTCAGTGAGAACAGTAACAACAAGAGAGCACCATACTGGACCAACACAGAA
AAGATGGAAAAGCGGCTCCATGCTGTGCCTGCGGCCAACACTGTCAAGTTTCGCTGCCCAGCCGGGGGGAACCCAATGCCAACCATGCGG
TGGCTGAAAAACGGGAAGGAGTTTAAGCAGGAGCATCGCATTGGAGGCTACAAGGTACGAAACCAGCACTGGAGCCTCATTATGGAAAGT
GTGGTCCCATCTGACAAGGGAAATTATACCTGTGTAGTGGAGAATGAATACGGGTCCATCAATCACACGTACCACCTGGATGTTGTGGCG
CCTGGAAGAGAAAAGGAGATTACAGCTTCCCCAGACTACCTGGAGATAGCCATTTACTGCATAGGGGTCTTCTTAATCGCCTGTATGGTG
GTAACAGTCATCCTGTGCCGAATGAAGAACACGACCAAGAAGCCAGACTTCAGCAGCCAGCCGGCTGTGCACAAGCTGACCAAACGTATC
CCCCTGCGGAGACAGGTAACAGTTTCGGCTGAGTCCAGCTCCTCCATGAACTCCAACACCCCGCTGGTGAGGATAACAACACGCCTCTCT
TCAACGGCAGACACCCCCATGCTGGCAGGGGTCTCCGAGTATGAACTTCCAGAGGACCCAAAATGGGAGTTTCCAAGAGATAAGCTGACA
CTGGGCAAGCCCCTGGGAGAAGGTTGCTTTGGGCAAGTGGTCATGGCGGAAGCAGTGGGAATTGACAAAGACAAGCCCAAGGAGGCGGTC
ACCGTGGCCGTGAAGATGTTGAAAGATGATGCCACAGAGAAAGACCTTTCTGATCTGGTGTCAGAGATGGAGATGATGAAGATGATTGGG
AAACACAAGAATATCATAAATCTTCTTGGAGCCTGCACACAGGATGGGCCTCTCTATGTCATAGTTGAGTATGCCTCTAAAGGCAACCTC
CGAGAATACCTCCGAGCCCGGAGGCCACCCGGGATGGAGTACTCCTATGACATTAACCGTGTTCCTGAGGAGCAGATGACCTTCAAGGAC
TTGGTGTCATGCACCTACCAGCTGGCCAGAGGCATGGAGTACTTGGCTTCCCAAAAATGTATTCATCGAGATTTAGCAGCCAGAAATGTT
TTGGTAACAGAAAACAATGTGATGAAAATAGCAGACTTTGGACTCGCCAGAGATATCAACAATATAGACTATTACAAAAAGACCACCAAT
GGGCGGCTTCCAGTCAAGTGGATGGCTCCAGAAGCCCTGTTTGATAGAGTATACACTCATCAGAGTGATGTCTGGTCCTTCGGGGTGTTA
ATGTGGGAGATCTTCACTTTAGGGGGCTCGCCCTACCCAGGGATTCCCGTGGAGGAACTTTTTAAGCTGCTGAAGGAAGGACACAGAATG
GATAAGCCAGCCAACTGCACCAACGAACTGTACATGATGATGAGGGACTGTTGGCATGCAGTGCCCTCCCAGAGACCAACGTTCAAGCAG
TTGGTAGAAGACTTGGATCGAATTCTCACTCTCACAACCAATGAGCAAGCCAGGGCTGAGCAGGAAGAAGAATTCATTAGTAACACTTTA
TTCAAGAAAATTCAGGCTTTGCAGAAGGAGAAAGAAACCCTTGCTGTAAATTATGAGAAAGAAGAAGAATTCCTCACTAATGAGCTCTCC
AGAAAATTGATGCAGTTGCAGCATGAGAAAGCCGAACTAGAACAGCATCTTGAACAAGAGCAGGAATTTCAGGTCAACAAACTGATGAAG
AAAATTAAAAAACTGGAGAATGACACCATTTCTAAGCAACTTACATTAGAACAGTTGAGACGGGAGAAGATTGACCTTGAAAATACATTG
GAACAAGAACAAGAAGCACTAGTTAATCGCCTCTGGAAAAGGATGGATAAGCTTGAAGCTGAAAAGCGAATCCTGCAGGAAAAATTAGAC
CAGCCCGTCTCTGCTCCACCATCGCCTAGAGATATCTCCATGGAGATTGATTCTCCAGAAAATATGATGCGTCACATCAGGTTTTTAAAG
AATGAAGTGGAACGGCTGAAGAAGCAACTGAGAGCTGCTCAGTTACAGCATTCAGAGAAAATGGCACAGTATCTGGAGGAGGAACGTCAC
ATGAGAGAAGAGAACTTGAGGCTCCAGAGGAAGCTGCAGAGGGAGATGGAGAGAAGAGAAGCCCTCTGTCGACAGCTCTCCGAGAGTGAG
TCCAGCTTAGAAATGGACGACGAAAGGTATTTTAATGAGATGTCTGCACAAGGATTAAGACCTCGCACTGTGTCCAGCCCGATCCCTTAC
ACACCTTCTCCGAGTTCAAGCAGGCCTATATCACCTGGTCTATCATATGCAAGTCACACGGTTGGTTTCACGCCACCAACTTCACTGACT
AGAGCTGGAATGTCTTATTACAATTCCCCGGGTCTTCACGTGCAGCACATGGGAACATCCCATGGTATCACAAGGCCTTCACCACGGAGA
AGCAACAGTCCTGACAAATTCAAACGGCCCACGCCGCCTCCATCTCCCAACACACAGACCCCAGTCCAGCCACCTCCGCCTCCACCTCCG
CCACCCATGCAGCCCACGGTCCCCTCAGCAGCCACCTCGCAGCCTACTCCTTCGCAACATTCGGCGCACCCCTCCTCCCAGCCTTAATGC
ATGAGCTTAGTCTGAATTTCAAGTTGGGACTCATCCAATGGAGCCGTCTACTCAACGCCAAAGGCTTCCTTCTCTGGCATATTTGGATAT
GACTTATTTGCACTGAGGTTATCTAGGCTTCACTATCCATTGTGTTGTAAATGTTTGTCAGAAATGCAGCCAGTGTTGTGGGTCTACAAC
ACTAACCAGACGACTTTTTCCATCAGTGTTTTACTTGAATCTTCATGTACGTCCATTCCCTGGCTGGAACCTTCGCTGTTTGGTATTTGG
TATTTCAGCAGCAGTGTGCAATTTTTGCTTGGCCCAGAGCTTCATTCTCCTGGCTTTTAGGTTTGTAAAAGAAAAAGGGATATCTTTTTT
ATATTTTTTTCCATGAATCTGCAGAAAATTACTGAGCTGTTGTTACCCTCCTCTCATTATAATAGTGTTTACCAAACATACCAATAATTC
AGCACTACAATTCAGACCTTTGAAAATCTGGCTTTCAGTGTAGAACAGAAAGTTAGATGAATCAGTGCCCAAGACATATTTTCTGTTTAA
CAGAACTTTCTACAGATACATTTTTTACAGGTTATTTTCATTGTGTTATTGACATCCATGTCTCTCGTAAAACAGATGGCCCAAAGTAAT
GAATCATGTGGCTGTACCTTCTCCACATAAATGGGATGGATAATTATCGTATATTAAGATGTGATTCTCTTTTTTATCCTTAATGTTAAT
CTACTTAACCTGGCCCCCTCTAACATGAGTCGATAAATGTTGTCCTACTCACCGGTGGTTTCAATGGCTAATTAGAATGTGTTATTTGAT
TTCTGCTGCAGAAGGCAGTGTGATTGTAACAAAAACAATGCGGCTTCCCCCTTTCGTACTTCATTTGTGTTCTCTTAAAATAGAGTTTGA
ACAAATATTTTAAAGGTGCAAAATACCATTAGAAAATACTATTTGAAATGGACATTATCGCATTATCTTGGCATAATGGCCAGAAAATAT
TGTATTGCTTGGCAGAAAAGAAAATAAGGTCTAAAGGAAAGTAGCACATTAGCATTGATGGCTGTTCATTTCACCCAGTATAAGCAAGTG
CAGTGTACAAAGAAGTATATTCTGAATACATTATTTCCATTCATTTAGCACAAATAAATCATTTGGTTTCACTTTGCAGTGGAACACTGA
GTCACTCTTTTCTTAACACGTGCAACATCTTAATTTTTGTTTTTCAGCAGTTGCTGTTTTGTACTTTGGTAGTAAAGTGATTTTTACCAC
CTGTGTTTGCATATTTATATATGCTGTGGATGAAAATAACTTACTAGAGAATGTATATTTTATGACAAGAATGTGTATCTGTTGGATATA
ATCAGAGAACTGAAAAGTAATTTATCAGTAATTTTTAAGAGTCCATGTTTTGTGACAACCATCTCTAATAGCCAACTCTTTATTAAACAC
ACTCCTAAAAATAAGGAACCATGACATTGTAGATATTTAATATTGTACAGTATAGAAACCTCCATTTTTGCCTTCGAATGCATATTTAAG
AGTTAACAGAATGAAAAAAAAAAGTCTTGTTGGATAATAGTGTTTGACTAGCGTTTTAAGAACTTGAGAGTAAAAGCAACAATAAGATTT
TTTCACCTCTTCCTGCTTCCACCCCCAAACTGAGAACATCACTCAATTGTTTGGAAGAAACTGTAGGTCTATATAAATTTTATTTATAAT
GTATGTGTAATATACATAATCATAATACAGTTCTCAGATGCAGGGAAGAAGTTTGGCATTTAATCATTGAGGCTTTAGGTTTTTGATGTG
ATCAGACTGGGCCATGTCAAACCCGGAATTTTCACCAACAGTTCACTCACCCTCCTGGTACATTGCCATTCCAAGGAATTCTGAGAGTAG
GCAAACAAATTTTGCCTTCATGGTACAGTTCTCAGTTTTTCTTATAGGAGAAATATGGTATATGTTTATAAGAATCTTTTATGAGATTAT
AGATTTCAATGCTGTGGATAGTGTCTTGCACCCAAACAAGAAAGTCCATAATGGAATGATCTTCCCTCAGCTTCCTATCGATTTAGTTAC
CTCTTGAAAGCACAAAAATTAAAACATTGCCATATGTTGAATTTTTAAAAAGCACTTGGAGTGAGCGAACATTTCCTGATAAATGCCTTT
TAGAGATAGGTTCTTGATATTCAGACATCTGCAGAAATGTTCTGGTTCCCAAAGTCATTTCACTTCGAAATAAAACACAGCTCCTTCAAA
CAGCACTTTTTCCACATAAATCTAGTTGCCTCTCCCTGTGGACATTCAGAACTGATAGAACAAACACTACTCTTTTGAATTTGATGGTTC
GTGTCCTTTAAAGTGTTTGAGGACCTATGCAGAGCCTGTAACACTTGGGTAGTACCTGCTAGGACAATTTCTTGGCAATTGTCTTACTAC
TAGGGATCAGTAAGATTTAGATTCTGAGCCCATAATGGCAACAGCCCCCTCACCTATGGGAAGCTGACTTCCCTCAGTCGGGCACTTCTC
ATGGGGGCTGAACATGGTTCCTGCCATTCTGTTACCCACTCTCCCAGGTGAGCCCTGGATTGGCTCCCAGAAGGCCTTTGTAAAATCAGT
AGCCGTCCTGCAGGCAGGTGGGAGCAACAGGGGCTTCAGTAGCTTCATTTTCCTGTCTTGCAGACAGAGACCCTTGGCTACCACTGTGCT
GCTAATAGGATAAGTACTCTGTTGCCAGATTACCATGCCTTTTATACAAAACCAAATTAACTTACCTAATACCTGACACCTCTTTGGGCT
CTGAACTGCTTTCTCTCATCAAGCATGCTAGCACTCTAGACAGAATTCTAGAAATTTGGCAGATAGTGGAAGCCTTTAATTGAACTTACT
CCTTCGTTGACTGAAAGGAGTTTTAAATTCTGAGCTCCTGAGATACTGACTAGCAACCATGGAATGAATGTGTGACCAGAAAGTGGCTTT
GACACCAAGTGCTACTGTCCCTTTGTAATTGGCTTCTAACAGAATTCAACCAGAAATAATTGATAATGTGAATTTTTGTTAATTGTTCAC
TTGTAGGAAAATAGAACATGTATCACCCTTTGTTAGGTAGACATGAACTTTTCCTGCACAAAGCCTTGCTTTTAGAGAATGCCCAATAAG
GCAAGAAAAAGCATAGTAACTTGTGCTTTGAGAGCTCAATATTTGTATCTTATCAGTACAGAAGAAATATTTCTGTGTAACTTGATCTTC
TGTCTAGTACTTGTCTTATAGGTAACCAACACTGAAAACTTTGTAGTGATGACTACCAAAGAAATACATAGTAAAACAACCTTTTATTTC
CAAATTGTTAAAGAGCCAGCCATTGATGCTGCTACATGAGTTCCATGCTCAAGAGCCATTGTAAGAGATTAAGGGGTTTCTAGGTTTTTG
GTGATTTTTTGTTTGTTTTTTTCTTTGTTTTTTAGGGTTTTTTTTTCTTCTTTAATTTTTTGATTAAAACATACACACAGCTGTTAGCAT
AAAGTCGTGGGGGGCATTTTCTGGAATGCTCAGCAGTTCTGATTAACTGCCAAGCCCAGGTTGCCTCTCATGAGGCAACTGAAAAAATCC
TGTGTCTTGATAGCATGGGTGCTGTGTGTGTGCATGTGTGTGTCTGCATTCATGCCTTAACTCGGGTTACTGCACAACTTTAGTTCTTGA
CTTAGTCTGCACCGTCATCTAGATTGTATTGTACATCTCGGTCTGAACTTCATCCTGGCAAAAACAAAGTTGCAGGCACAACAGTTTAAG
AATGCATTCCTCCAGAAGAGTATCTGGTCAGGTTGACCCCTGAGCCTTCTTTGGACTTGATTTGGAACTTAGCCTGGAAAGCGAAAGTGG
ACTGTCCAACAGAAAGATGTCAACAAGGAAAAGAGGAGAGCCAAGCGCTAGCATGCCTTTTGCCTCTGCATATCTGTGCACACTGTATGT
TGTTCATGATAGCTTGTCTACAACTTGACTAGGTTGGAGTTCTGGTAATAGTGGCAATCTTGACATTCTTGGTCAGAGTTTAGAGAGATG
TAAGACTTTCAATTAATGTCTTATTTACTCCTTTATGTTGATTAGTCTTTGATACATGTGCTGAATCAGAAACCTAAATAAAGATAATTT

>In-frame_FGFR2_ENST00000346997_chr10_123243212_-_CCDC6_ENST00000263102_chr10_61612460_-_7583nt
GGTACCGTAACCATGGTCAGCTGGGGTCGTTTCATCTGCCTGGTCGTGGTCACCATGGCAACCTTGTCCCTGGCCCGGCCCTCCTTCAGT
TTAGTTGAGGATACCACATTAGAGCCAGAAGAGCCACCAACCAAATACCAAATCTCTCAACCAGAAGTGTACGTGGCTGCGCCAGGGGAG
TCGCTAGAGGTGCGCTGCCTGTTGAAAGATGCCGCCGTGATCAGTTGGACTAAGGATGGGGTGCACTTGGGGCCCAACAATAGGACAGTG
CTTATTGGGGAGTACTTGCAGATAAAGGGCGCCACGCCTAGAGACTCCGGCCTCTATGCTTGTACTGCCAGTAGGACTGTAGACAGTGAA
ACTTGGTACTTCATGGTGAATGTCACAGATGCCATCTCATCCGGAGATGATGAGGATGACACCGATGGTGCGGAAGATTTTGTCAGTGAG
AACAGTAACAACAAGAGAGCACCATACTGGACCAACACAGAAAAGATGGAAAAGCGGCTCCATGCTGTGCCTGCGGCCAACACTGTCAAG
TTTCGCTGCCCAGCCGGGGGGAACCCAATGCCAACCATGCGGTGGCTGAAAAACGGGAAGGAGTTTAAGCAGGAGCATCGCATTGGAGGC
TACAAGGTACGAAACCAGCACTGGAGCCTCATTATGGAAAGTGTGGTCCCATCTGACAAGGGAAATTATACCTGTGTAGTGGAGAATGAA
TACGGGTCCATCAATCACACGTACCACCTGGATGTTGTGGAGCGATCGCCTCACCGGCCCATCCTCCAAGCCGGACTGCCGGCAAATGCC
TCCACAGTGGTCGGAGGAGACGTAGAGTTTGTCTGCAAGGTTTACAGTGATGCCCAGCCCCACATCCAGTGGATCAAGCACGTGGAAAAG
AACGGCAGTAAATACGGGCCCGACGGGCTGCCCTACCTCAAGGTTCTCAAGGCCGCCGGTGTTAACACCACGGACAAAGAGATTGAGGTT
CTCTATATTCGGAATGTAACTTTTGAGGACGCTGGGGAATATACGTGCTTGGCGGGTAATTCTATTGGGATATCCTTTCACTCTGCATGG
TTGACAGTTCTGCCAGCGCCTGGAAGAGAAAAGGAGATTACAGCTTCCCCAGACTACCTGGAGATAGCCATTTACTGCATAGGGGTCTTC
TTAATCGCCTGTATGGTGGTAACAGTCATCCTGTGCCGAATGAAGAACACGACCAAGAAGCCAGACTTCAGCAGCCAGCCGGCTGTGCAC
AAGCTGACCAAACGTATCCCCCTGCGGAGACAGGTTTCGGCTGAGTCCAGCTCCTCCATGAACTCCAACACCCCGCTGGTGAGGATAACA
ACACGCCTCTCTTCAACGGCAGACACCCCCATGCTGGCAGGGGTCTCCGAGTATGAACTTCCAGAGGACCCAAAATGGGAGTTTCCAAGA
GATAAGCTGACACTGGGCAAGCCCCTGGGAGAAGGTTGCTTTGGGCAAGTGGTCATGGCGGAAGCAGTGGGAATTGACAAAGACAAGCCC
AAGGAGGCGGTCACCGTGGCCGTGAAGATGTTGAAAGATGATGCCACAGAGAAAGACCTTTCTGATCTGGTGTCAGAGATGGAGATGATG
AAGATGATTGGGAAACACAAGAATATCATAAATCTTCTTGGAGCCTGCACACAGGATGGGCCTCTCTATGTCATAGTTGAGTATGCCTCT
AAAGGCAACCTCCGAGAATACCTCCGAGCCCGGAGGCCACCCGGGATGGAGTACTCCTATGACATTAACCGTGTTCCTGAGGAGCAGATG
ACCTTCAAGGACTTGGTGTCATGCACCTACCAGCTGGCCAGAGGCATGGAGTACTTGGCTTCCCAAAAATGTATTCATCGAGATTTAGCA
GCCAGAAATGTTTTGGTAACAGAAAACAATGTGATGAAAATAGCAGACTTTGGACTCGCCAGAGATATCAACAATATAGACTATTACAAA
AAGACCACCAATGGGCGGCTTCCAGTCAAGTGGATGGCTCCAGAAGCCCTGTTTGATAGAGTATACACTCATCAGAGTGATGTCTGGTCC
TTCGGGGTGTTAATGTGGGAGATCTTCACTTTAGGGGGCTCGCCCTACCCAGGGATTCCCGTGGAGGAACTTTTTAAGCTGCTGAAGGAA
GGACACAGAATGGATAAGCCAGCCAACTGCACCAACGAACTGTACATGATGATGAGGGACTGTTGGCATGCAGTGCCCTCCCAGAGACCA
ACGTTCAAGCAGTTGGTAGAAGACTTGGATCGAATTCTCACTCTCACAACCAATGAGCAAGCCAGGGCTGAGCAGGAAGAAGAATTCATT
AGTAACACTTTATTCAAGAAAATTCAGGCTTTGCAGAAGGAGAAAGAAACCCTTGCTGTAAATTATGAGAAAGAAGAAGAATTCCTCACT
AATGAGCTCTCCAGAAAATTGATGCAGTTGCAGCATGAGAAAGCCGAACTAGAACAGCATCTTGAACAAGAGCAGGAATTTCAGGTCAAC
AAACTGATGAAGAAAATTAAAAAACTGGAGAATGACACCATTTCTAAGCAACTTACATTAGAACAGTTGAGACGGGAGAAGATTGACCTT
GAAAATACATTGGAACAAGAACAAGAAGCACTAGTTAATCGCCTCTGGAAAAGGATGGATAAGCTTGAAGCTGAAAAGCGAATCCTGCAG
GAAAAATTAGACCAGCCCGTCTCTGCTCCACCATCGCCTAGAGATATCTCCATGGAGATTGATTCTCCAGAAAATATGATGCGTCACATC
AGGTTTTTAAAGAATGAAGTGGAACGGCTGAAGAAGCAACTGAGAGCTGCTCAGTTACAGCATTCAGAGAAAATGGCACAGTATCTGGAG
GAGGAACGTCACATGAGAGAAGAGAACTTGAGGCTCCAGAGGAAGCTGCAGAGGGAGATGGAGAGAAGAGAAGCCCTCTGTCGACAGCTC
TCCGAGAGTGAGTCCAGCTTAGAAATGGACGACGAAAGGTATTTTAATGAGATGTCTGCACAAGGATTAAGACCTCGCACTGTGTCCAGC
CCGATCCCTTACACACCTTCTCCGAGTTCAAGCAGGCCTATATCACCTGGTCTATCATATGCAAGTCACACGGTTGGTTTCACGCCACCA
ACTTCACTGACTAGAGCTGGAATGTCTTATTACAATTCCCCGGGTCTTCACGTGCAGCACATGGGAACATCCCATGGTATCACAAGGCCT
TCACCACGGAGAAGCAACAGTCCTGACAAATTCAAACGGCCCACGCCGCCTCCATCTCCCAACACACAGACCCCAGTCCAGCCACCTCCG
CCTCCACCTCCGCCACCCATGCAGCCCACGGTCCCCTCAGCAGCCACCTCGCAGCCTACTCCTTCGCAACATTCGGCGCACCCCTCCTCC
CAGCCTTAATGCATGAGCTTAGTCTGAATTTCAAGTTGGGACTCATCCAATGGAGCCGTCTACTCAACGCCAAAGGCTTCCTTCTCTGGC
ATATTTGGATATGACTTATTTGCACTGAGGTTATCTAGGCTTCACTATCCATTGTGTTGTAAATGTTTGTCAGAAATGCAGCCAGTGTTG
TGGGTCTACAACACTAACCAGACGACTTTTTCCATCAGTGTTTTACTTGAATCTTCATGTACGTCCATTCCCTGGCTGGAACCTTCGCTG
TTTGGTATTTGGTATTTCAGCAGCAGTGTGCAATTTTTGCTTGGCCCAGAGCTTCATTCTCCTGGCTTTTAGGTTTGTAAAAGAAAAAGG
GATATCTTTTTTATATTTTTTTCCATGAATCTGCAGAAAATTACTGAGCTGTTGTTACCCTCCTCTCATTATAATAGTGTTTACCAAACA
TACCAATAATTCAGCACTACAATTCAGACCTTTGAAAATCTGGCTTTCAGTGTAGAACAGAAAGTTAGATGAATCAGTGCCCAAGACATA
TTTTCTGTTTAACAGAACTTTCTACAGATACATTTTTTACAGGTTATTTTCATTGTGTTATTGACATCCATGTCTCTCGTAAAACAGATG
GCCCAAAGTAATGAATCATGTGGCTGTACCTTCTCCACATAAATGGGATGGATAATTATCGTATATTAAGATGTGATTCTCTTTTTTATC
CTTAATGTTAATCTACTTAACCTGGCCCCCTCTAACATGAGTCGATAAATGTTGTCCTACTCACCGGTGGTTTCAATGGCTAATTAGAAT
GTGTTATTTGATTTCTGCTGCAGAAGGCAGTGTGATTGTAACAAAAACAATGCGGCTTCCCCCTTTCGTACTTCATTTGTGTTCTCTTAA
AATAGAGTTTGAACAAATATTTTAAAGGTGCAAAATACCATTAGAAAATACTATTTGAAATGGACATTATCGCATTATCTTGGCATAATG
GCCAGAAAATATTGTATTGCTTGGCAGAAAAGAAAATAAGGTCTAAAGGAAAGTAGCACATTAGCATTGATGGCTGTTCATTTCACCCAG
TATAAGCAAGTGCAGTGTACAAAGAAGTATATTCTGAATACATTATTTCCATTCATTTAGCACAAATAAATCATTTGGTTTCACTTTGCA
GTGGAACACTGAGTCACTCTTTTCTTAACACGTGCAACATCTTAATTTTTGTTTTTCAGCAGTTGCTGTTTTGTACTTTGGTAGTAAAGT
GATTTTTACCACCTGTGTTTGCATATTTATATATGCTGTGGATGAAAATAACTTACTAGAGAATGTATATTTTATGACAAGAATGTGTAT
CTGTTGGATATAATCAGAGAACTGAAAAGTAATTTATCAGTAATTTTTAAGAGTCCATGTTTTGTGACAACCATCTCTAATAGCCAACTC
TTTATTAAACACACTCCTAAAAATAAGGAACCATGACATTGTAGATATTTAATATTGTACAGTATAGAAACCTCCATTTTTGCCTTCGAA
TGCATATTTAAGAGTTAACAGAATGAAAAAAAAAAGTCTTGTTGGATAATAGTGTTTGACTAGCGTTTTAAGAACTTGAGAGTAAAAGCA
ACAATAAGATTTTTTCACCTCTTCCTGCTTCCACCCCCAAACTGAGAACATCACTCAATTGTTTGGAAGAAACTGTAGGTCTATATAAAT
TTTATTTATAATGTATGTGTAATATACATAATCATAATACAGTTCTCAGATGCAGGGAAGAAGTTTGGCATTTAATCATTGAGGCTTTAG
GTTTTTGATGTGATCAGACTGGGCCATGTCAAACCCGGAATTTTCACCAACAGTTCACTCACCCTCCTGGTACATTGCCATTCCAAGGAA
TTCTGAGAGTAGGCAAACAAATTTTGCCTTCATGGTACAGTTCTCAGTTTTTCTTATAGGAGAAATATGGTATATGTTTATAAGAATCTT
TTATGAGATTATAGATTTCAATGCTGTGGATAGTGTCTTGCACCCAAACAAGAAAGTCCATAATGGAATGATCTTCCCTCAGCTTCCTAT
CGATTTAGTTACCTCTTGAAAGCACAAAAATTAAAACATTGCCATATGTTGAATTTTTAAAAAGCACTTGGAGTGAGCGAACATTTCCTG
ATAAATGCCTTTTAGAGATAGGTTCTTGATATTCAGACATCTGCAGAAATGTTCTGGTTCCCAAAGTCATTTCACTTCGAAATAAAACAC
AGCTCCTTCAAACAGCACTTTTTCCACATAAATCTAGTTGCCTCTCCCTGTGGACATTCAGAACTGATAGAACAAACACTACTCTTTTGA
ATTTGATGGTTCGTGTCCTTTAAAGTGTTTGAGGACCTATGCAGAGCCTGTAACACTTGGGTAGTACCTGCTAGGACAATTTCTTGGCAA
TTGTCTTACTACTAGGGATCAGTAAGATTTAGATTCTGAGCCCATAATGGCAACAGCCCCCTCACCTATGGGAAGCTGACTTCCCTCAGT
CGGGCACTTCTCATGGGGGCTGAACATGGTTCCTGCCATTCTGTTACCCACTCTCCCAGGTGAGCCCTGGATTGGCTCCCAGAAGGCCTT
TGTAAAATCAGTAGCCGTCCTGCAGGCAGGTGGGAGCAACAGGGGCTTCAGTAGCTTCATTTTCCTGTCTTGCAGACAGAGACCCTTGGC
TACCACTGTGCTGCTAATAGGATAAGTACTCTGTTGCCAGATTACCATGCCTTTTATACAAAACCAAATTAACTTACCTAATACCTGACA
CCTCTTTGGGCTCTGAACTGCTTTCTCTCATCAAGCATGCTAGCACTCTAGACAGAATTCTAGAAATTTGGCAGATAGTGGAAGCCTTTA
ATTGAACTTACTCCTTCGTTGACTGAAAGGAGTTTTAAATTCTGAGCTCCTGAGATACTGACTAGCAACCATGGAATGAATGTGTGACCA
GAAAGTGGCTTTGACACCAAGTGCTACTGTCCCTTTGTAATTGGCTTCTAACAGAATTCAACCAGAAATAATTGATAATGTGAATTTTTG
TTAATTGTTCACTTGTAGGAAAATAGAACATGTATCACCCTTTGTTAGGTAGACATGAACTTTTCCTGCACAAAGCCTTGCTTTTAGAGA
ATGCCCAATAAGGCAAGAAAAAGCATAGTAACTTGTGCTTTGAGAGCTCAATATTTGTATCTTATCAGTACAGAAGAAATATTTCTGTGT
AACTTGATCTTCTGTCTAGTACTTGTCTTATAGGTAACCAACACTGAAAACTTTGTAGTGATGACTACCAAAGAAATACATAGTAAAACA
ACCTTTTATTTCCAAATTGTTAAAGAGCCAGCCATTGATGCTGCTACATGAGTTCCATGCTCAAGAGCCATTGTAAGAGATTAAGGGGTT
TCTAGGTTTTTGGTGATTTTTTGTTTGTTTTTTTCTTTGTTTTTTAGGGTTTTTTTTTCTTCTTTAATTTTTTGATTAAAACATACACAC
AGCTGTTAGCATAAAGTCGTGGGGGGCATTTTCTGGAATGCTCAGCAGTTCTGATTAACTGCCAAGCCCAGGTTGCCTCTCATGAGGCAA
CTGAAAAAATCCTGTGTCTTGATAGCATGGGTGCTGTGTGTGTGCATGTGTGTGTCTGCATTCATGCCTTAACTCGGGTTACTGCACAAC
TTTAGTTCTTGACTTAGTCTGCACCGTCATCTAGATTGTATTGTACATCTCGGTCTGAACTTCATCCTGGCAAAAACAAAGTTGCAGGCA
CAACAGTTTAAGAATGCATTCCTCCAGAAGAGTATCTGGTCAGGTTGACCCCTGAGCCTTCTTTGGACTTGATTTGGAACTTAGCCTGGA
AAGCGAAAGTGGACTGTCCAACAGAAAGATGTCAACAAGGAAAAGAGGAGAGCCAAGCGCTAGCATGCCTTTTGCCTCTGCATATCTGTG
CACACTGTATGTTGTTCATGATAGCTTGTCTACAACTTGACTAGGTTGGAGTTCTGGTAATAGTGGCAATCTTGACATTCTTGGTCAGAG
TTTAGAGAGATGTAAGACTTTCAATTAATGTCTTATTTACTCCTTTATGTTGATTAGTCTTTGATACATGTGCTGAATCAGAAACCTAAA

>In-frame_FGFR2_ENST00000369056_chr10_123243212_-_CCDC6_ENST00000263102_chr10_61612460_-_7604nt
GGACCGGGGATTGGTACCGTAACCATGGTCAGCTGGGGTCGTTTCATCTGCCTGGTCGTGGTCACCATGGCAACCTTGTCCCTGGCCCGG
CCCTCCTTCAGTTTAGTTGAGGATACCACATTAGAGCCAGAAGAGCCACCAACCAAATACCAAATCTCTCAACCAGAAGTGTACGTGGCT
GCGCCAGGGGAGTCGCTAGAGGTGCGCTGCCTGTTGAAAGATGCCGCCGTGATCAGTTGGACTAAGGATGGGGTGCACTTGGGGCCCAAC
AATAGGACAGTGCTTATTGGGGAGTACTTGCAGATAAAGGGCGCCACGCCTAGAGACTCCGGCCTCTATGCTTGTACTGCCAGTAGGACT
GTAGACAGTGAAACTTGGTACTTCATGGTGAATGTCACAGATGCCATCTCATCCGGAGATGATGAGGATGACACCGATGGTGCGGAAGAT
TTTGTCAGTGAGAACAGTAACAACAAGAGAGCACCATACTGGACCAACACAGAAAAGATGGAAAAGCGGCTCCATGCTGTGCCTGCGGCC
AACACTGTCAAGTTTCGCTGCCCAGCCGGGGGGAACCCAATGCCAACCATGCGGTGGCTGAAAAACGGGAAGGAGTTTAAGCAGGAGCAT
CGCATTGGAGGCTACAAGGTACGAAACCAGCACTGGAGCCTCATTATGGAAAGTGTGGTCCCATCTGACAAGGGAAATTATACCTGTGTA
GTGGAGAATGAATACGGGTCCATCAATCACACGTACCACCTGGATGTTGTGGAGCGATCGCCTCACCGGCCCATCCTCCAAGCCGGACTG
CCGGCAAATGCCTCCACAGTGGTCGGAGGAGACGTAGAGTTTGTCTGCAAGGTTTACAGTGATGCCCAGCCCCACATCCAGTGGATCAAG
CACGTGGAAAAGAACGGCAGTAAATACGGGCCCGACGGGCTGCCCTACCTCAAGGTTCTCAAGCACTCGGGGATAAATAGTTCCAATGCA
GAAGTGCTGGCTCTGTTCAATGTGACCGAGGCGGATGCTGGGGAATATATATGTAAGGTCTCCAATTATATAGGGCAGGCCAACCAGTCT
GCCTGGCTCACTGTCCTGCCAAAACAGCAAGCGCCTGGAAGAGAAAAGGAGATTACAGCTTCCCCAGACTACCTGGAGATAGCCATTTAC
TGCATAGGGGTCTTCTTAATCGCCTGTATGGTGGTAACAGTCATCCTGTGCCGAATGAAGAACACGACCAAGAAGCCAGACTTCAGCAGC
CAGCCGGCTGTGCACAAGCTGACCAAACGTATCCCCCTGCGGAGACAGGTAACAGTTTCGGCTGAGTCCAGCTCCTCCATGAACTCCAAC
ACCCCGCTGGTGAGGATAACAACACGCCTCTCTTCAACGGCAGACACCCCCATGCTGGCAGGGGTCTCCGAGTATGAACTTCCAGAGGAC
CCAAAATGGGAGTTTCCAAGAGATAAGCTGACACTGGGCAAGCCCCTGGGAGAAGGTTGCTTTGGGCAAGTGGTCATGGCGGAAGCAGTG
GGAATTGACAAAGACAAGCCCAAGGAGGCGGTCACCGTGGCCGTGAAGATGTTGAAAGATGATGCCACAGAGAAAGACCTTTCTGATCTG
GTGTCAGAGATGGAGATGATGAAGATGATTGGGAAACACAAGAATATCATAAATCTTCTTGGAGCCTGCACACAGGATGGGCCTCTCTAT
GTCATAGTTGAGTATGCCTCTAAAGGCAACCTCCGAGAATACCTCCGAGCCCGGAGGCCACCCGGGATGGAGTACTCCTATGACATTAAC
CGTGTTCCTGAGGAGCAGATGACCTTCAAGGACTTGGTGTCATGCACCTACCAGCTGGCCAGAGGCATGGAGTACTTGGCTTCCCAAAAA
TGTATTCATCGAGATTTAGCAGCCAGAAATGTTTTGGTAACAGAAAACAATGTGATGAAAATAGCAGACTTTGGACTCGCCAGAGATATC
AACAATATAGACTATTACAAAAAGACCACCAATGGGCGGCTTCCAGTCAAGTGGATGGCTCCAGAAGCCCTGTTTGATAGAGTATACACT
CATCAGAGTGATGTCTGGTCCTTCGGGGTGTTAATGTGGGAGATCTTCACTTTAGGGGGCTCGCCCTACCCAGGGATTCCCGTGGAGGAA
CTTTTTAAGCTGCTGAAGGAAGGACACAGAATGGATAAGCCAGCCAACTGCACCAACGAACTGTACATGATGATGAGGGACTGTTGGCAT
GCAGTGCCCTCCCAGAGACCAACGTTCAAGCAGTTGGTAGAAGACTTGGATCGAATTCTCACTCTCACAACCAATGAGCAAGCCAGGGCT
GAGCAGGAAGAAGAATTCATTAGTAACACTTTATTCAAGAAAATTCAGGCTTTGCAGAAGGAGAAAGAAACCCTTGCTGTAAATTATGAG
AAAGAAGAAGAATTCCTCACTAATGAGCTCTCCAGAAAATTGATGCAGTTGCAGCATGAGAAAGCCGAACTAGAACAGCATCTTGAACAA
GAGCAGGAATTTCAGGTCAACAAACTGATGAAGAAAATTAAAAAACTGGAGAATGACACCATTTCTAAGCAACTTACATTAGAACAGTTG
AGACGGGAGAAGATTGACCTTGAAAATACATTGGAACAAGAACAAGAAGCACTAGTTAATCGCCTCTGGAAAAGGATGGATAAGCTTGAA
GCTGAAAAGCGAATCCTGCAGGAAAAATTAGACCAGCCCGTCTCTGCTCCACCATCGCCTAGAGATATCTCCATGGAGATTGATTCTCCA
GAAAATATGATGCGTCACATCAGGTTTTTAAAGAATGAAGTGGAACGGCTGAAGAAGCAACTGAGAGCTGCTCAGTTACAGCATTCAGAG
AAAATGGCACAGTATCTGGAGGAGGAACGTCACATGAGAGAAGAGAACTTGAGGCTCCAGAGGAAGCTGCAGAGGGAGATGGAGAGAAGA
GAAGCCCTCTGTCGACAGCTCTCCGAGAGTGAGTCCAGCTTAGAAATGGACGACGAAAGGTATTTTAATGAGATGTCTGCACAAGGATTA
AGACCTCGCACTGTGTCCAGCCCGATCCCTTACACACCTTCTCCGAGTTCAAGCAGGCCTATATCACCTGGTCTATCATATGCAAGTCAC
ACGGTTGGTTTCACGCCACCAACTTCACTGACTAGAGCTGGAATGTCTTATTACAATTCCCCGGGTCTTCACGTGCAGCACATGGGAACA
TCCCATGGTATCACAAGGCCTTCACCACGGAGAAGCAACAGTCCTGACAAATTCAAACGGCCCACGCCGCCTCCATCTCCCAACACACAG
ACCCCAGTCCAGCCACCTCCGCCTCCACCTCCGCCACCCATGCAGCCCACGGTCCCCTCAGCAGCCACCTCGCAGCCTACTCCTTCGCAA
CATTCGGCGCACCCCTCCTCCCAGCCTTAATGCATGAGCTTAGTCTGAATTTCAAGTTGGGACTCATCCAATGGAGCCGTCTACTCAACG
CCAAAGGCTTCCTTCTCTGGCATATTTGGATATGACTTATTTGCACTGAGGTTATCTAGGCTTCACTATCCATTGTGTTGTAAATGTTTG
TCAGAAATGCAGCCAGTGTTGTGGGTCTACAACACTAACCAGACGACTTTTTCCATCAGTGTTTTACTTGAATCTTCATGTACGTCCATT
CCCTGGCTGGAACCTTCGCTGTTTGGTATTTGGTATTTCAGCAGCAGTGTGCAATTTTTGCTTGGCCCAGAGCTTCATTCTCCTGGCTTT
TAGGTTTGTAAAAGAAAAAGGGATATCTTTTTTATATTTTTTTCCATGAATCTGCAGAAAATTACTGAGCTGTTGTTACCCTCCTCTCAT
TATAATAGTGTTTACCAAACATACCAATAATTCAGCACTACAATTCAGACCTTTGAAAATCTGGCTTTCAGTGTAGAACAGAAAGTTAGA
TGAATCAGTGCCCAAGACATATTTTCTGTTTAACAGAACTTTCTACAGATACATTTTTTACAGGTTATTTTCATTGTGTTATTGACATCC
ATGTCTCTCGTAAAACAGATGGCCCAAAGTAATGAATCATGTGGCTGTACCTTCTCCACATAAATGGGATGGATAATTATCGTATATTAA
GATGTGATTCTCTTTTTTATCCTTAATGTTAATCTACTTAACCTGGCCCCCTCTAACATGAGTCGATAAATGTTGTCCTACTCACCGGTG
GTTTCAATGGCTAATTAGAATGTGTTATTTGATTTCTGCTGCAGAAGGCAGTGTGATTGTAACAAAAACAATGCGGCTTCCCCCTTTCGT
ACTTCATTTGTGTTCTCTTAAAATAGAGTTTGAACAAATATTTTAAAGGTGCAAAATACCATTAGAAAATACTATTTGAAATGGACATTA
TCGCATTATCTTGGCATAATGGCCAGAAAATATTGTATTGCTTGGCAGAAAAGAAAATAAGGTCTAAAGGAAAGTAGCACATTAGCATTG
ATGGCTGTTCATTTCACCCAGTATAAGCAAGTGCAGTGTACAAAGAAGTATATTCTGAATACATTATTTCCATTCATTTAGCACAAATAA
ATCATTTGGTTTCACTTTGCAGTGGAACACTGAGTCACTCTTTTCTTAACACGTGCAACATCTTAATTTTTGTTTTTCAGCAGTTGCTGT
TTTGTACTTTGGTAGTAAAGTGATTTTTACCACCTGTGTTTGCATATTTATATATGCTGTGGATGAAAATAACTTACTAGAGAATGTATA
TTTTATGACAAGAATGTGTATCTGTTGGATATAATCAGAGAACTGAAAAGTAATTTATCAGTAATTTTTAAGAGTCCATGTTTTGTGACA
ACCATCTCTAATAGCCAACTCTTTATTAAACACACTCCTAAAAATAAGGAACCATGACATTGTAGATATTTAATATTGTACAGTATAGAA
ACCTCCATTTTTGCCTTCGAATGCATATTTAAGAGTTAACAGAATGAAAAAAAAAAGTCTTGTTGGATAATAGTGTTTGACTAGCGTTTT
AAGAACTTGAGAGTAAAAGCAACAATAAGATTTTTTCACCTCTTCCTGCTTCCACCCCCAAACTGAGAACATCACTCAATTGTTTGGAAG
AAACTGTAGGTCTATATAAATTTTATTTATAATGTATGTGTAATATACATAATCATAATACAGTTCTCAGATGCAGGGAAGAAGTTTGGC
ATTTAATCATTGAGGCTTTAGGTTTTTGATGTGATCAGACTGGGCCATGTCAAACCCGGAATTTTCACCAACAGTTCACTCACCCTCCTG
GTACATTGCCATTCCAAGGAATTCTGAGAGTAGGCAAACAAATTTTGCCTTCATGGTACAGTTCTCAGTTTTTCTTATAGGAGAAATATG
GTATATGTTTATAAGAATCTTTTATGAGATTATAGATTTCAATGCTGTGGATAGTGTCTTGCACCCAAACAAGAAAGTCCATAATGGAAT
GATCTTCCCTCAGCTTCCTATCGATTTAGTTACCTCTTGAAAGCACAAAAATTAAAACATTGCCATATGTTGAATTTTTAAAAAGCACTT
GGAGTGAGCGAACATTTCCTGATAAATGCCTTTTAGAGATAGGTTCTTGATATTCAGACATCTGCAGAAATGTTCTGGTTCCCAAAGTCA
TTTCACTTCGAAATAAAACACAGCTCCTTCAAACAGCACTTTTTCCACATAAATCTAGTTGCCTCTCCCTGTGGACATTCAGAACTGATA
GAACAAACACTACTCTTTTGAATTTGATGGTTCGTGTCCTTTAAAGTGTTTGAGGACCTATGCAGAGCCTGTAACACTTGGGTAGTACCT
GCTAGGACAATTTCTTGGCAATTGTCTTACTACTAGGGATCAGTAAGATTTAGATTCTGAGCCCATAATGGCAACAGCCCCCTCACCTAT
GGGAAGCTGACTTCCCTCAGTCGGGCACTTCTCATGGGGGCTGAACATGGTTCCTGCCATTCTGTTACCCACTCTCCCAGGTGAGCCCTG
GATTGGCTCCCAGAAGGCCTTTGTAAAATCAGTAGCCGTCCTGCAGGCAGGTGGGAGCAACAGGGGCTTCAGTAGCTTCATTTTCCTGTC
TTGCAGACAGAGACCCTTGGCTACCACTGTGCTGCTAATAGGATAAGTACTCTGTTGCCAGATTACCATGCCTTTTATACAAAACCAAAT
TAACTTACCTAATACCTGACACCTCTTTGGGCTCTGAACTGCTTTCTCTCATCAAGCATGCTAGCACTCTAGACAGAATTCTAGAAATTT
GGCAGATAGTGGAAGCCTTTAATTGAACTTACTCCTTCGTTGACTGAAAGGAGTTTTAAATTCTGAGCTCCTGAGATACTGACTAGCAAC
CATGGAATGAATGTGTGACCAGAAAGTGGCTTTGACACCAAGTGCTACTGTCCCTTTGTAATTGGCTTCTAACAGAATTCAACCAGAAAT
AATTGATAATGTGAATTTTTGTTAATTGTTCACTTGTAGGAAAATAGAACATGTATCACCCTTTGTTAGGTAGACATGAACTTTTCCTGC
ACAAAGCCTTGCTTTTAGAGAATGCCCAATAAGGCAAGAAAAAGCATAGTAACTTGTGCTTTGAGAGCTCAATATTTGTATCTTATCAGT
ACAGAAGAAATATTTCTGTGTAACTTGATCTTCTGTCTAGTACTTGTCTTATAGGTAACCAACACTGAAAACTTTGTAGTGATGACTACC
AAAGAAATACATAGTAAAACAACCTTTTATTTCCAAATTGTTAAAGAGCCAGCCATTGATGCTGCTACATGAGTTCCATGCTCAAGAGCC
ATTGTAAGAGATTAAGGGGTTTCTAGGTTTTTGGTGATTTTTTGTTTGTTTTTTTCTTTGTTTTTTAGGGTTTTTTTTTCTTCTTTAATT
TTTTGATTAAAACATACACACAGCTGTTAGCATAAAGTCGTGGGGGGCATTTTCTGGAATGCTCAGCAGTTCTGATTAACTGCCAAGCCC
AGGTTGCCTCTCATGAGGCAACTGAAAAAATCCTGTGTCTTGATAGCATGGGTGCTGTGTGTGTGCATGTGTGTGTCTGCATTCATGCCT
TAACTCGGGTTACTGCACAACTTTAGTTCTTGACTTAGTCTGCACCGTCATCTAGATTGTATTGTACATCTCGGTCTGAACTTCATCCTG
GCAAAAACAAAGTTGCAGGCACAACAGTTTAAGAATGCATTCCTCCAGAAGAGTATCTGGTCAGGTTGACCCCTGAGCCTTCTTTGGACT
TGATTTGGAACTTAGCCTGGAAAGCGAAAGTGGACTGTCCAACAGAAAGATGTCAACAAGGAAAAGAGGAGAGCCAAGCGCTAGCATGCC
TTTTGCCTCTGCATATCTGTGCACACTGTATGTTGTTCATGATAGCTTGTCTACAACTTGACTAGGTTGGAGTTCTGGTAATAGTGGCAA
TCTTGACATTCTTGGTCAGAGTTTAGAGAGATGTAAGACTTTCAATTAATGTCTTATTTACTCCTTTATGTTGATTAGTCTTTGATACAT


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FusionGenePPI for FGFR2_CCDC6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FGFR2FGF1, FGFR2, FGF7, FGF10, PIK3R1, ITGA5, STAT3, PGR, STAT5A, STAT5B, NEDD4, FRS2, CBL, LYN, FYN, HGS, APP, PPM1A, TSPAN3, C8orf74, BEX1, BEX2, ERRFI1, GLCE, HOXC6, MTA3, PDLIM2, RASL10B, RHOBTB2, S100A14, TFF1, FGF5, FGF23, FGF8, PLCG1, FGF2, FGF3, FGF6, FGF9, FGF17, PVRL1, BRAF, MAP3K1, PTPN6, PTPN11, PTPN12, PTPRR, FGFR3, FGFR1, SNX24, GAPVD1, SNX22, UBE4A, IP6K1, RPS6KA3, IFFO2, TMEM30B, DNAJC30, XPR1, GOLGA3, KIDINS220, BCL11A, CEP295, CD44, RPS6KA2, LRRIQ1, RPS6KA1, LITAF, MRAP2, SDC2, FCGRT, SIGLECL1, RAET1E, FAM171B, CHERP, U2SURP, SLC9A6, TIMP1, CCDC120, CD83, PKP4, UBXN4, CTDSP1, CTDSPL, DUSP14, MTMR3CCDC6PPP4C, USP7, CREB1, ATF2, PPP1CA, HDAC1, ELAVL1, CUL1, SKP1, FBXW7, CSNK2A1, YWHAB, BRCC3, SF3A1, CD2AP, GAPVD1, HNRNPR, NR3C1, PAAF1, PPP4R2, TRIM28, PPP2R1A, CEP170, PPP2CB, RASSF7, ZNF444, TCL1B, MAFF, DDI2, NUDC, SARS, SEPT2, NTRK1, XPO1, P4HB, PPP2CA, PPP4R1, POLG2, GSK3B, CCNB1, CDK1, MTMR7, CEP55, TRPC4AP, C1S, RALBP1, MTUS2, LZTS3, EXOC1, ZNF331, PDE4DIP, FBXO42, CCDC102A, SMEK2, SMEK1, TCP10L, PCBP3, APC, LPXN, ZNF445, NECAB1, RPTOR, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FGFR2_CCDC6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneFGFR2P21802DB00039PaliferminFibroblast growth factor receptor 2biotechapproved
HgeneFGFR2P21802DB08896RegorafenibFibroblast growth factor receptor 2small moleculeapproved
HgeneFGFR2P21802DB09079NintedanibFibroblast growth factor receptor 2small moleculeapproved
HgeneFGFR2P21802DB01109HeparinFibroblast growth factor receptor 2small moleculeapproved|investigational
HgeneFGFR2P21802DB08901PonatinibFibroblast growth factor receptor 2small moleculeapproved|investigational
HgeneFGFR2P21802DB09078LenvatinibFibroblast growth factor receptor 2small moleculeapproved|investigational
HgeneFGFR2P21802DB01041ThalidomideFibroblast growth factor receptor 2small moleculeapproved|investigational|withdrawn

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RelatedDiseases for FGFR2_CCDC6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFGFR2C2931196Craniofacial dysostosis type 121ORPHANET;UNIPROT
HgeneFGFR2C0220658Pfeiffer Syndrome10UNIPROT
HgeneFGFR2C0001193Apert syndrome8ORPHANET;UNIPROT
HgeneFGFR2C1510455Acrocephalosyndactylia4CTD_human
HgeneFGFR2C0010278Craniosynostosis3CTD_human;HPO
HgeneFGFR2C0036341Schizophrenia3PSYGENET
HgeneFGFR2C0376634Craniofacial Abnormalities3CTD_human
HgeneFGFR2C1458155Mammary Neoplasms3CTD_human
HgeneFGFR2C0011570Mental Depression2PSYGENET
HgeneFGFR2C0011581Depressive disorder2PSYGENET
HgeneFGFR2C0038356Stomach Neoplasms2CTD_human
HgeneFGFR2C1865070SCAPHOCEPHALY, MAXILLARY RETRUSION, AND MENTAL RETARDATION2CTD_human;ORPHANET;UNIPROT
HgeneFGFR2C0003090Ankylosis1CTD_human
HgeneFGFR2C0005586Bipolar Disorder1PSYGENET
HgeneFGFR2C0008924Cleft Lip1CTD_human
HgeneFGFR2C0008925Cleft Palate1CTD_human;HPO
HgeneFGFR2C0010273Craniofacial Dysostosis1CTD_human;HPO
HgeneFGFR2C0014170Endometrial Neoplasms1CTD_human
HgeneFGFR2C0018553Hamartoma Syndrome, Multiple1CTD_human
HgeneFGFR2C0023890Liver Cirrhosis1CTD_human
HgeneFGFR2C0024121Lung Neoplasms1CTD_human
HgeneFGFR2C0026613Motor Skills Disorders1CTD_human
HgeneFGFR2C0033975Psychotic Disorders1PSYGENET
HgeneFGFR2C0037268Skin Abnormalities1CTD_human
HgeneFGFR2C0037274Dermatologic disorders1CTD_human
HgeneFGFR2C0040427Tooth Abnormalities1CTD_human
HgeneFGFR2C0080178Spina Bifida1CTD_human
HgeneFGFR2C0206698Cholangiocarcinoma1CTD_human
HgeneFGFR2C0206762Limb Deformities, Congenital1CTD_human
HgeneFGFR2C0265269Lacrimoauriculodentodigital syndrome1CTD_human;ORPHANET;UNIPROT
HgeneFGFR2C0349204Nonorganic psychosis1PSYGENET
HgeneFGFR2C1450010Plagiocephaly, Nonsynostotic1CTD_human;HPO
HgeneFGFR2C1852406Cutis Gyrata Syndrome of Beare And Stevenson1CTD_human;ORPHANET;UNIPROT
HgeneFGFR2C2350233Antley-Bixler Syndrome Phenotype1CTD_human
HgeneFGFR2C3281247BENT BONE DYSPLASIA SYNDROME1ORPHANET;UNIPROT
HgeneFGFR2C3714756Intellectual Disability1CTD_human;HPO