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Fusion gene ID: 13387

FusionGeneSummary for FGFR1_BCR

Fusion gene summary

Fusion gene information	Fusion gene name: FGFR1_BCR
	Fusion gene ID: 13387
		Hgene	Tgene
	Gene symbol	FGFR1	BCR
	Gene ID	2260	613
	Gene name	fibroblast growth factor receptor 1	BCR, RhoGEF and GTPase activating protein
	Synonyms	BFGFR\|CD331\|CEK\|ECCL\|FGFBR\|FGFR-1\|FLG\|FLT-2\|FLT2\|HBGFR\|HH2\|HRTFDS\|KAL2\|N-SAM\|OGD\|bFGF-R-1	ALL\|BCR1\|CML\|D22S11\|D22S662\|PHL
	Cytomap	8p11.23	22q11.23
	Type of gene	protein-coding	protein-coding
	Description	fibroblast growth factor receptor 1FGFR1/PLAG1 fusionFMS-like tyrosine kinase 2basic fibroblast growth factor receptor 1fms-related tyrosine kinase 2heparin-binding growth factor receptorhydroxyaryl-protein kinaseproto-oncogene c-Fgr	breakpoint cluster region proteinBCR/FGFR1 chimera proteinFGFR1/BCR chimera proteinbreakpoint cluster regionrenal carcinoma antigen NY-REN-26
	Modification date	20180527	20180527
	UniProtAcc	P11362	P11274
	Ensembl transtripts involved in fusion gene	ENST00000425967, ENST00000397091, ENST00000447712, ENST00000341462, ENST00000532791, ENST00000397113, ENST00000356207, ENST00000335922, ENST00000326324, ENST00000397103, ENST00000397108, ENST00000496629,	ENST00000305877, ENST00000359540, ENST00000398512, ENST00000436990,
Fusion gene scores	* DoF score	11 X 9 X 5=495	6 X 12 X 4=288
	# samples	12	15
	** MAII score	log2(12/495*10)=-2.04439411935845 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(15/288*10)=-0.941106310946431 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: FGFR1 [Title/Abstract] AND BCR [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	FGFR1	GO:0008284	positive regulation of cell proliferation	8663044
Hgene	FGFR1	GO:0008543	fibroblast growth factor receptor signaling pathway	8663044
Hgene	FGFR1	GO:0010863	positive regulation of phospholipase C activity	18480409
Hgene	FGFR1	GO:0018108	peptidyl-tyrosine phosphorylation	8622701\|18480409
Hgene	FGFR1	GO:0043406	positive regulation of MAP kinase activity	8622701\|18480409
Hgene	FGFR1	GO:0046777	protein autophosphorylation	8622701
Hgene	FGFR1	GO:2000546	positive regulation of endothelial cell chemotaxis to fibroblast growth factor	21885851

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			AJ298917	FGFR1	chr8	38277056	-	BCR	chr22	23610592	+
ChiTaRS3.1			AB742171	FGFR1	chr8	38277056	-	BCR	chr22	23610592	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000425967	ENST00000305877	FGFR1	chr8	38277056	-	BCR	chr22	23610592	+
Frame-shift	ENST00000425967	ENST00000359540	FGFR1	chr8	38277056	-	BCR	chr22	23610592	+
5CDS-intron	ENST00000425967	ENST00000398512	FGFR1	chr8	38277056	-	BCR	chr22	23610592	+
5CDS-intron	ENST00000425967	ENST00000436990	FGFR1	chr8	38277056	-	BCR	chr22	23610592	+
In-frame	ENST00000397091	ENST00000305877	FGFR1	chr8	38277056	-	BCR	chr22	23610592	+
In-frame	ENST00000397091	ENST00000359540	FGFR1	chr8	38277056	-	BCR	chr22	23610592	+
5CDS-intron	ENST00000397091	ENST00000398512	FGFR1	chr8	38277056	-	BCR	chr22	23610592	+
5CDS-intron	ENST00000397091	ENST00000436990	FGFR1	chr8	38277056	-	BCR	chr22	23610592	+
In-frame	ENST00000447712	ENST00000305877	FGFR1	chr8	38277056	-	BCR	chr22	23610592	+
In-frame	ENST00000447712	ENST00000359540	FGFR1	chr8	38277056	-	BCR	chr22	23610592	+
5CDS-intron	ENST00000447712	ENST00000398512	FGFR1	chr8	38277056	-	BCR	chr22	23610592	+
5CDS-intron	ENST00000447712	ENST00000436990	FGFR1	chr8	38277056	-	BCR	chr22	23610592	+
In-frame	ENST00000341462	ENST00000305877	FGFR1	chr8	38277056	-	BCR	chr22	23610592	+
In-frame	ENST00000341462	ENST00000359540	FGFR1	chr8	38277056	-	BCR	chr22	23610592	+
5CDS-intron	ENST00000341462	ENST00000398512	FGFR1	chr8	38277056	-	BCR	chr22	23610592	+
5CDS-intron	ENST00000341462	ENST00000436990	FGFR1	chr8	38277056	-	BCR	chr22	23610592	+
In-frame	ENST00000532791	ENST00000305877	FGFR1	chr8	38277056	-	BCR	chr22	23610592	+
In-frame	ENST00000532791	ENST00000359540	FGFR1	chr8	38277056	-	BCR	chr22	23610592	+
5CDS-intron	ENST00000532791	ENST00000398512	FGFR1	chr8	38277056	-	BCR	chr22	23610592	+
5CDS-intron	ENST00000532791	ENST00000436990	FGFR1	chr8	38277056	-	BCR	chr22	23610592	+
In-frame	ENST00000397113	ENST00000305877	FGFR1	chr8	38277056	-	BCR	chr22	23610592	+
In-frame	ENST00000397113	ENST00000359540	FGFR1	chr8	38277056	-	BCR	chr22	23610592	+
5CDS-intron	ENST00000397113	ENST00000398512	FGFR1	chr8	38277056	-	BCR	chr22	23610592	+
5CDS-intron	ENST00000397113	ENST00000436990	FGFR1	chr8	38277056	-	BCR	chr22	23610592	+
In-frame	ENST00000356207	ENST00000305877	FGFR1	chr8	38277056	-	BCR	chr22	23610592	+
In-frame	ENST00000356207	ENST00000359540	FGFR1	chr8	38277056	-	BCR	chr22	23610592	+
5CDS-intron	ENST00000356207	ENST00000398512	FGFR1	chr8	38277056	-	BCR	chr22	23610592	+
5CDS-intron	ENST00000356207	ENST00000436990	FGFR1	chr8	38277056	-	BCR	chr22	23610592	+
Frame-shift	ENST00000335922	ENST00000305877	FGFR1	chr8	38277056	-	BCR	chr22	23610592	+
Frame-shift	ENST00000335922	ENST00000359540	FGFR1	chr8	38277056	-	BCR	chr22	23610592	+
5CDS-intron	ENST00000335922	ENST00000398512	FGFR1	chr8	38277056	-	BCR	chr22	23610592	+
5CDS-intron	ENST00000335922	ENST00000436990	FGFR1	chr8	38277056	-	BCR	chr22	23610592	+
In-frame	ENST00000326324	ENST00000305877	FGFR1	chr8	38277056	-	BCR	chr22	23610592	+
In-frame	ENST00000326324	ENST00000359540	FGFR1	chr8	38277056	-	BCR	chr22	23610592	+
5CDS-intron	ENST00000326324	ENST00000398512	FGFR1	chr8	38277056	-	BCR	chr22	23610592	+
5CDS-intron	ENST00000326324	ENST00000436990	FGFR1	chr8	38277056	-	BCR	chr22	23610592	+
In-frame	ENST00000397103	ENST00000305877	FGFR1	chr8	38277056	-	BCR	chr22	23610592	+
In-frame	ENST00000397103	ENST00000359540	FGFR1	chr8	38277056	-	BCR	chr22	23610592	+
5CDS-intron	ENST00000397103	ENST00000398512	FGFR1	chr8	38277056	-	BCR	chr22	23610592	+
5CDS-intron	ENST00000397103	ENST00000436990	FGFR1	chr8	38277056	-	BCR	chr22	23610592	+
Frame-shift	ENST00000397108	ENST00000305877	FGFR1	chr8	38277056	-	BCR	chr22	23610592	+
Frame-shift	ENST00000397108	ENST00000359540	FGFR1	chr8	38277056	-	BCR	chr22	23610592	+
5CDS-intron	ENST00000397108	ENST00000398512	FGFR1	chr8	38277056	-	BCR	chr22	23610592	+
5CDS-intron	ENST00000397108	ENST00000436990	FGFR1	chr8	38277056	-	BCR	chr22	23610592	+
intron-3CDS	ENST00000496629	ENST00000305877	FGFR1	chr8	38277056	-	BCR	chr22	23610592	+
intron-3CDS	ENST00000496629	ENST00000359540	FGFR1	chr8	38277056	-	BCR	chr22	23610592	+
intron-intron	ENST00000496629	ENST00000398512	FGFR1	chr8	38277056	-	BCR	chr22	23610592	+
intron-intron	ENST00000496629	ENST00000436990	FGFR1	chr8	38277056	-	BCR	chr22	23610592	+

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FusionProtFeatures for FGFR1_BCR

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FGFR1 P11362	BCR P11274

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Fusion gene ID: 13387

FusionGeneSummary for FGFR1_BCR

FusionProtFeatures for FGFR1_BCR